Dynamic Parameters Test of Micro-Machined Gyroscope Based on LabVIEW

针对当前测试微机械陀螺动态参数存在耗时长、效率低等缺点,提出了一种新的测试陀螺动态参数的方法,该方法通过lAb-VIEW编写的测试软件控制一数据采集卡和信号调理电路激励陀螺振动并采集其驱动方向上的振动数据,从采集的振动数据中提取出波峰和波谷进行指数拟合获取陀螺的衰减系数和固有频率,最后根据阻尼振动方程计算出陀螺的阻尼比和谐振频率,同时获取陀螺的品质因子;该方法能够实现自动记录和处理陀螺的振动数据;整个测试过程只需15S左右,提高了测试效率;利用该方法测试了30种不同气压下陀螺的品质因子,得到的陀螺的品质因子与气压值的关系曲线和理论研究结果相符,从而为陀螺动态参数的测试提供了一种有效的手段。For the current method test dynamic parameters of Micro-machined Gyroscope has some defects,such as time-consuming and low efficiency,a new method test dynamic parameters of gyroscope is put forward in this paper,this method control a data acquisition card and signal regulate circuit to drive gyroscope vibrate and collect the vibration data on the drive direction of gyroscope by a test software written in the LabVIEW,then extract peaks and troughs from the vibration data to get the attenuation coefficient and the inherent frequency of gyroscope through index fitting,finally calculated the damping ratio and the resonant frequency of gyroscope according to the damping vibration equation and get the quality factor at the same time.The method can realize recording and processing the vibration data of gyroscope automatically.The entire testing process takes about 15 seconds,so this method has improved the test efficiency.Using this method tested the quality factor of the gyroscope in 30 different pressure,the relation curve of quality factor and the pressure value is conform to the theoretical results,thus this paper provide an effective means for the dynamic parameter test of gyroscope.航空科学基金(20110868001

Mechanism Underlying the Brain-specific Membrane-anchored Protein TMEM59L-mediated Apoptosis

TMEM59l为近年来新发现的脑特异性高表达蛋白,具有促凋亡效果,但其具体的凋亡机制还不清楚.构建了TMEM59l重组质粒,并在HEk293T细胞中过表达TMEM59l,用AnnEXIn V-fITC/PI双染法确定了TMEM59l可以诱导细胞凋亡,之后用免疫印迹方法检测细胞内凋亡相关分子激活情况.结果显示,外源TMEM59l可以降低bCl-2的蛋白表达水平,诱导细胞色素C从线粒体释放进入细胞质,并且激活CASPASE-9、CASPASE-7和CASPASE-3,但不激活CASPASE-8;活化的CASPASE-7和CASPASE-3进一步酶解死亡底物PArP,导致细胞凋亡;此外,用广谱CASPASE抑制剂z-VAl-AlA-ASP-fMk(z-VAd-fMk)抑制CASPASE-7和CASPASE-3活性后,死亡底物PArP的酶解也基本被抑制.由此可见,TMEM59l是通过CASPASE依赖的线粒体途径诱导HEk293T细胞凋亡.Apoptosis plays a key role in multiple biological functions and dysregulation of apoptosis leads to disease pathogenesis.Therefore,identification of new proteins mediating apoptosis and elucidation of the underlying mechanism is important not only for basic research but also for disease intervention.TMEM59L is a newly-found brain-specific anchored protein with very limited information.One study reported that TMEM59L could induce apoptosis.But the underlying mechanism remains elusive.In this paper,TMEM59L recombinant plasmid was constructed and transfected into HEK293 cells.Through Annexin V-FITC/ propidium iodide double staining and flow cytometry assay,it was confirmed that overexpression of TMEM59L could dramatically induce cell apoptosis.Through Westen blotting study,it was also found that overexpression of TMEM59L could reduce the protein level of Bcl-2,induce cytochrome c release from mitochondria to the cytosol,and activate caspase-9,caspase-3 and caspase-7,but not caspase-8.Consistently,overexpression of TMEM59L promoted the cleavage of death substrate PARP by activated caspases.While cleavage of PARP upon TMEM59L overexpression was dramatically decreased when cells were treated with a caspase inhibitor Z-Val-Ala-Asp-FMK(Z-VAD-FMK).Together these results suggest that TMEM59L can induce apoptosis through a caspase-dependent mitochondrial pathway.Because of its high abundance in the brain,TMEM59L might participate in the physiological apoptosis during neural development and/or pathological apoptosis during neurodegenerative diseases,and these deserve further investigation.国家自然科学基金项目(30973150);国家重点基础研究发展计划(973)前期研究专项项目(2010CB535004);国家科技重大专项项目(2009ZX09103-731);福建省自然科学杰出青年基金项目(2009J06022

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies