Analysis about ultrasonic misdiagnosis of lower extremity venous thrombosis

目的通过对下肢静脉血栓超声患者的超声资料进行回顾性分析,总结分析误诊漏诊的原因方法对70例临床怀疑为下肢静脉血栓的病人进行常规静脉彩超检查,对确诊为下肢静脉血栓的患者再行CT静脉造影检查,而后对两者诊断结果进行对照分析。结果 70例临床疑似为下肢静脉血栓病人中,确诊率为57.1%（40/70）,超声误诊率32%（8/25）。结论超声检查无创伤、重复性高,可准确诊断下肢静脉血栓形成。Objective The data of patients with lower extremity venous thrombosis were analyzed retrospectively, and the causes of misdiagnosis and missed diagnosis were summarized. Methods 70 patients with clinical suspicion of lower extremity venous thrombosis were treated by routine venous color Doppler ultrasonography, and the venous thrombosis was diagnosed by CT venous angiography.Results Among 700 patients with clinical suspicion of lower extremity venous thrombosis, the accuracy rate was 57.1%, and the misdiagnosis rate was 32%. Conclusion Because ultrasound examination has high repeatability and no trauma, it can be used to diagnose exactly the lower extremity venous thrombosis.昌吉回族自治州科技局项目（TG-201405

LD端面泵浦固体激光谐振腔的研究

为了对激光谐振腔体进行优化设计,采用ABCD光学传输矩阵理论,计算得到具有普适性的三镜折叠腔内高斯模式束腰的解析解.对一典型平平热透镜腔进行计算分析,结果表明:在针对其进行优化设计的泵浦范围内,腔体稳定性很好,激光光斑半径基本不随泵浦功率变化而波动.实验中以808nm尾纤输出的激光二极管端面泵浦Nd:YAG晶体产生连续1064nm激光,激光输出结果与理论模型值能够较好地相符

Study on Relationship between the Molecular Folding and Activity of ALkaline Phosphatase From Sinonovacula Constricty in the Presence of Guanidine Hydrochloride

报道了缢蛏碱性磷酸酶（简称AlP）经不同浓度盐酸胍处理时酶的分子构象所发生的变化以及酶变化和失活的动力学过程。在胍中酶荧光发射峰强度下降，紫外差光谱在246nM和285nM处出现2个负峰，Cd谱中酶的α螺旋度下降，且随浓度增大，变化程度也加大。动力学研究表明，酶在0.5MOl/l、1.0MOl/l、2.0MOl/l3.0MOl/l、4.0MOl/l盐酸胍中的变性速度常数分别为3.21x10-（-4）S-（-1）、6.38x10-（-4）S-（-1）、2.17x10-（-3）S-（-1）、2.33x10-（-3）S-9-1）、5.17x10-（-3）S-（-1）；而酶在相应盐酸胍中的失活速度常数分别为2.33x10-（-4）S-（-1）、3.57x10-（-4）S-（-1）、5.86x10-（-4）S-（-1）、1.14x10-（-3）S-（-1）、3.45x10-（-3）S-（-1）；表现为失活与构象伸展变化基本平行。EFFect of guanidine hydrochloride (GuHcl) on the changes in molecular conFormation and activity, kinetics of denaturation and inactivation of alkaline phosphatase (ALP)From Sinonovacula constrica are reported in this essay.In the presence of guanidine, the Flu rescence emission peak of ALP decreased; On the other hand, two negative peaks merged at the wavelengths of 246 nm and 285 nm on the UV diFFerential spectra;and the αhelix degree in the circular dichroism spectra reduced.Denaturation rate constants of ALP in diFFerent concentrations of GuHCl (0.5 , 1.0 , 2.0 , 3.0, 4.0 mol/L) measured by Fluorescence were 3.21×10￣(-4), 6.38×10￣(-4) , 2.17×10￣(-3) , 2.33×10￣(-3) and 5.16×10￣(-3)s￣(-1) ,respectively.Meanwhile the respective inactivation rate constants were 2.33×10￣(-4) , 3.57 × 10￣(-4), 5.86×10￣(-4), 1.14×10￣(-3) and 3.45×10￣(-3)s￣(-1).Results indicate that the rates of conFormational changes of ALP in the presence of GuHCl are slightly Faster than those of inactivation, though they all Fall in the same order of magnitude.We propose to call such relationship the ″synchronous alteration type″ For rate changes in conFormation and inactivation of the same order during denaturation.国家自然科学基

Pollution History and Sources of Organotin Compounds in Aquaculture Water of Tong'an Bay,Xiamen

通过对厦门同安湾养殖海域沉积物柱样(柱深180 CM)中6种不同形态有机锡化合物(丁基锡和苯基锡)的gC-fPd定量分析测定,并结合210Pb同位素定年,追溯了该地区近几十年来有机锡污染的沉积历史(1931~2007年).研究表明,该海域从20世纪50年代(0~80 CM段)开始出现有机锡化合物污染,总有机锡化合物的含量(干重)在3.43~69.6 ng.g-1之间,平均值为15.0 ng.g-1,其中丁基锡化合物含量分布范围为2.51~68.8 ng.g-1(平均值14.6 ng.g-1),约占总有机锡含量的97.4%,降解产物以一丁基锡为主要形态;苯基锡仅占2.58%.与世界其他港口海湾沉积物中有机锡的污染相比,厦门同安湾丁基锡化合物的污染处于较低水平.该养殖区域以丁基锡污染为主,推测来源于早期的船舶防污漆,苯基锡的少量检出可能来源于船舶防护漆使用时的副产品.同时,该海域沉积物中有机锡化合物的含量和组成分布特征,表明其可能受到水动力条件和海上建筑、船舶防污漆泄漏的双重影响,而海水养殖造成的影响也不容忽视.有机锡化合物的沉积历史分析表明,柱样中有机锡化合物含量的垂直分布特征,较好重现了该地域有机锡化合物的使用历史和在一定程度上反映了同安湾海域功能区划的改变.Six organotin compounds(OTs) in core sediment collected from aquaculture water of Tong'an Bay,Xiamen were detected by GC-FPD.Based on 210Pb-dating data,the pollution history(from 1931 to 2007) of OTs in this area was reconstructed and their possible sources were also discussed.The results showed that the inputs of organotin compounds in this sea area began from 1950's(0-80 cm).The vertical concentrations of OTs ranged from 3.43-69.6 ng·g-1(dry weight),the mean value was 15.0 ng·g-1.Butyltins concentrations ranged from 2.51-68.8 ng·g-1 and the average concentration was 14.6 ng·g-1 which accounted for 97.4% of total OTs,while phenyltins just accounted for 2.58%.It is indicated that the aquaculture waters of Tong'an Bay were mainly contaminated by butyltin compounds,inferring that they may come from the early antifouling paint of ships.The distributions of OTs concentrations and compositions may be related to the complex influence of the hydrodynamic conditions,antifouling paint leakages from ships and marine structures,and aquaculture.Compared to the other harbors and bays,the magnitude of OTs pollution in the sediment from Tong'an Bay was at the low midpoint on a global scale.Moreover,the sedimentary history showed that,vertical OTs distributions were in good agreement with the usage history of organotin compounds as antifouling paints and the changes of the major function regionalization in the surrounding area.国家自然科学基金项目(20777060);国家海洋局海洋三所基本科研业务费专项(海三科2007019

Physical health care monitoring for people with serious mental illness

Background Current guidance suggests that we should monitor the physical health of people with serious mental illness and there has been a significant financial investment over recent years to provide this. Objectives To assess the effectiveness of physical health monitoring as a means of reducing morbidity, mortality and reduction in quality of life in people with serious mental illness. Search methods We searched the Cochrane Schizophrenia Group Trials Register (October 2009) which is based on regular searches of CINAHL, EMBASE, MEDLINE and PsycINFO. Selection criteria All randomised or quasi-randomised clinical trials focusing on physical health monitoring versus standard care or comparing i) self monitoring vs monitoring by health care professional; ii) simple vs complex monitoring; iii) specific vs non-specific checks iv) once only vs regular checks or v) comparison of different guidance. Data collection and analysis The authors (GT, AC, SM) independently screened search results and identified three studies as possibly fulfilling the review's criteria. On examination, however, all three were subsequently excluded. Main results We did not identify any randomised trials which assessed the effectiveness of physical health monitoring in people with serious mental illness. Authors' conclusions There is no evidence from randomised trials to support current guidance and practice. Guidance and practice are based on expert consensus, clinical experience and good intentions rather than high quality evidenc

Photochemical Fluorescence Characteristics of Nitrazepam and Its Application

提出了一种光化学荧光分析法 (PCFA)测定硝基安定的新方法 .在弱碱性介质中 ,硝基安定溶液经紫外光照射后 ,发生光化学反应 ,其产物具有荧光特性 ,λex=35 3nm ,λem=46 0nm .硝基安定的浓度在 0 .2 5～ 4.0 0 μg/mL范围内 ,荧光相对强度与硝基安定的浓度成良好的线性关系 ,方法的相对标准偏差和检测限分别为 2 .0 %和 45ng/mL ,可直接用于片剂中硝基安定含量的测定A new method was developed for determination of nitrazepam by photochemical fluorescence analysis (PCFA). In weak alkaline medium (pH=9.5), photochemical reaction of nitrazepam can occur under the irradiation of UV-light and produce a fluorescent product (λ ex=353 nm,λ em=460 nm). The fluorescence intensity is linearly inceased with the concentration of nitrazepam over the range of 0.25～4.00 μg/mL. The relative standard deviation and detection limit are 2.0% and 45 ng/mL, respectively. This method has been applied to the determination of nitrazepam in tablets.福建省自然科学基金资助项目 (B96 0 0 3