A study of psychosedation in the Department of Dental Anesthesiology, Matsumoto Dental University Hospital

We analyzed the dental patients treated with psychosedation in the Department of Dental Anesthesiology, Matsumoto Dental University Hospital over the past 14−year period on the clinical records and anesthesia records. Of a total of 2802 patients, 2285 were treated on an outpatient basis and 517 were hospitalized for treatment. As for age distribution, the age group of 20−29 years old was the most dominant, while gender distribution was 46% males and 54% females. Psychosedation was performed most often for ‘minimizing stress related to systemic illness’ (n=992), followed by ‘fear of highly−invasive dental treatment.’ When divided by the type of sedative therapy, treatment was given as intravenous sedation in 2035 patients, nitrous oxide inhalation sedation in 740 and combined (intravenous−inhalation) sedation in 27. The agents used for intravenous sedation were midazolam in 887 and flunitrazepam in 856 patients. The clinical departments where sedation was given to patients varied, though the Department of Oral Surgery was predominant with 73% of the patients (n=2055). We also found that the number of psychosedation cases were showing an increasing trend, as the number of patients in 2011 was approximately 4 times greater than in 1998. As reasons for that increase, we consider that psychosedation has become more well known by both clinicians and patients, and that the prevalence is increasing along with the aging of society in Japan. As for the type of sedation, the ratio of intravenous sedation cases was high, which is likely because a sedative effect can be reliably obtained with a greater level of sedation than nitrous oxide inhalation sedation. At our institution, a predominant num- ber of sedation cases were treated in the Department of Oral Surgery, with tooth extraction the most common procedure requiring a sedative. We speculated that this department performs highly invasive treatments, such as tooth extraction, as compared to others and that high−risk patients with systemic illness were often referred by practitioners in other departments

淹没式贝壳填料生物滤池的除磷效应

　探讨了以贝壳为填料的生物滤池的除磷机理,研究了影响除磷效果的主要因素。静态试验结果表明:在酸性条件下贝壳能够通过化学作用去除水中的磷。连续试验结果显示:当控制水力停留时间在5h以上时贝壳显示出较高的除磷效率;当贝壳与陶粒的填充高度之比为2∶1时除磷效果最佳,除磷率可达75%～85%

Pyrazinamide Therapy on Pulmonary Tuberculosis

Article信州醫學雜誌 6(1): 14-24(1957)journal articl

強力ナグラボンによる肝硬変症の治療

Article信州醫學雜誌 8(9): 1828-1830(1959)journal articl

三重県における地域別食生活実態の公衆栄養学的考察 : 第17報 昭和60年,三重県阿山郡大山田村東小学校学童の家庭における栄養摂取状態(自然科学編)

三重県における学童の健康をめぐる食生活の今日的な課題とその栄養指導対策を得る目的で,昭和53年より平坦部市街化地域の鈴鹿市庄野小学校および山間部の阿山郡大山田村東小学校を対象として,毎年継続実施してきたが,今回は後者の本県において循環器疾患およびガン死亡率が高い地域であり,かつ,上野保健所管内のうちでも,さらに高率村である阿山郡大山田村東小学校学童のみを対象としてその家庭食事(朝食・夕食および間食)の栄養摂取状態について調査を行なった。(1)栄養素別摂取量の各栄養素別標準量に対する有意差を検討した結果は,男子においては,総たん白質および動物性たん白質の摂取量が99%の信頼度で標準量を上回っていた。女子においては,動物性たん白質の摂取量が99%の信頼度で標準量を上回っていたが,植物性たん白質の摂取量のみは99%の信頼度で標準量を下回っていた。カルシウムについては女子のみが95%の信頼度で標準量を下回っていた。ビタミンについてはビタミンB_2が女子のみ99%の信頼度で標準量を下回っていた。(2)栄養摂取量の標準量に対する充足率について男子と女子との間の有意差をうると,エネルギー,総たん白質,動物性たん白質およびビタミンB_1の各栄養素に有意差がみられとくにビタミンB_1において,女子は男子のそれよりも摂取不足が著しいことが注目された。なお,カルシウム,ビタミンB_2および繊維は男子・女子ともに摂取不足がみられた。(3)性別,各栄養素別摂取量に対する未満児を個人別にみた場合は,前述のごとく充足していた栄養素においても個人差が大きく,その摂取量の未満児が,かなり認められた。(4)PFC比の平均値については,男子・女子とも適正な範囲と見なされ,かつ,男子と女子との間には有意差はみられなかった。(5)殻物エネルギー比と動物性たん白質比との相関関係は男子・女子ともに99%の信頼度で認められた。動物性たん白質比と植物性脂肪/動物性脂肪との間の相関関係は男子において95%の信頼度で認められたが,女子においてはその相関関係は認められなかった。(6)植物性脂肪/動物性脂肪については,男子0.80,女子0.98であり,やや不適正な値を示したが,本調査では一価不飽和脂肪酸含量の多い魚油を考慮した場合は適正な値であった。魚油を含むその植物性脂肪/動物性脂肪についてもその変動係数は大きく,1.0以下の者が男子43.8%,女子30.0%の存在は否定しえず,脂肪の質についての特別な指導が必要と考えられる。(7)食塩摂取過剰と粗繊維の摂取不足傾向がみられた。(8)孤食学童・家族全員食別学童の栄養摂取量において,孤食学童にビタミンAの不足が95%信頼度で認められた。ついで,カルシウムおよびビタミンB_2においても摂取不足の傾向は認められた。Studies have been conducted continuously each year since 1978 at the Shono Elementary School in Suzuka city and the Higashi Elementary School in Ohyamada-mura, Ayama-gun, for the purposes of determining the elements of present-day diets as they relate to the health of students and to determine nutritional guidelines. The present study, however, focussed only on the students at Higashi Elementary School in Ayama-gun, which is located in a region which has a high incidence of cardiovascular disease and a high cancer-related death rate, even throughout the jurisdiction of the Ueno Health Center, and encompassed the conditions of nutrient intake of at-home diets (breakfast, dinner and between meal snacks). 1) The results of investigations into significant differences in the consumed and standard amounts of each nutrient showed, with 99% reliability, that the consumption of total and animal proteins by boys exceeded the standard levels. While the consumption of animal proteins for girls was shown with 99% reliability to be above standard levels, the consumption of vegetable proteins was below standard levels. The intake of calcium was shown, with 95% reliability, to be below the standard level only for girls, while consumption of vitamin B_2 was also shown to be below the standard level only for girls. 2) In examining differences between boys and girls in meeting standard levels of consumed nutrients, significant differences were found in the consumption of each of the energy用roducing nutrients such as total proteins, animal proteins and vitamin B_1. An inadequacy of vitamin B_1 consumption in particular, was much worse for girls than for boys. Insufficient intake of calcium and vitamin B_2 were also observed. 3) In examining individual differences of sex and amounts of each consumed nutrient for pupils who had below standard levels consumption, it was observed that great individual differences occured even in nutrients with adequate consumption levels. 4) The mean value in the PFC ratio for boys and girls fell withim the appropriate region, and no significant differences were abserved between them. 5) A correlation between the ratio of energy from cereals and the ratio of animal proteins was observed in both and girls with 99% reliability. While a correlation between the animal protein ratio and vegetable fats/animal fats was observed with 95% reliability for boys, no such correlation was observed for girls. 6) In regard to the ratio of vegetable and animal fats, values of 0.80 for boys and 0.98 for girls were determined and while these are somewhat inappropriate values, they are appropriate for this study when considered in light of the many mono・unsaturated fatty acids found in fish oils. The coefficient of variation is large for the vegetable fat/animal fat ratio which includes fish oils. The existence of pupils for whom this coefficient was less than 1.0 is undeniable at 43.8% of the boys and 30.0% of the girls. It is beliened that particular guidance is required concerning fatty substances in the diet. 7) A tendency for excessive salt intake and inadequate intake of rough fiver were observed. 8) In differentiating nutrient intake between students who ate alone and those who ate with their families, an insufficiency of vitamin A intake was observed, with 95% reliability, for students who ate alone. A tendency was also noticed towards inadequate calcium and vitamin B_2 intake

Observation results by the TAMA300 detector on gravitational wave bursts from stellar-core collapses

We present data-analysis schemes and results of observations with the TAMA300 gravitational-wave detector, targeting burst signals from stellar-core collapse events. In analyses for burst gravitational waves, the detection and fake-reduction schemes are different from well-investigated ones for a chirp-wave analysis, because precise waveform templates are not available. We used an excess-power filter for the extraction of gravitational-wave candidates, and developed two methods for the reduction of fake events caused by non-stationary noises of the detector. These analysis schemes were applied to real data from the TAMA300 interferometric gravitational wave detector. As a result, fake events were reduced by a factor of about 1000 in the best cases. The resultant event candidates were interpreted from an astronomical viewpoint. We set an upper limit of 2.2x10^3 events/sec on the burst gravitational-wave event rate in our Galaxy with a confidence level of 90%. This work sets a milestone and prospects on the search for burst gravitational waves, by establishing an analysis scheme for the observation data from an interferometric gravitational wave detector

Clinical early phase II study of bicalutamide (Casodex) in patients with prostatic cancer

ビカルタミド1日1回50mg群, 80mg及び100mgを12週間投与する3群比較の無作為化非盲検試験を実施した. 1)登録症例は124例で, 適格例は122例であった. 2)総合効果における奏効率は50mg群, 80mg群及び100mg群でそれぞれ50.5%, 61.0%及び53.7%であった. 3)PSAに対する奏効率は50mg群, 80mg群及び100mg群でそれぞれ84.2%, 92.7%及び97.6%であった. 4)副作用発現率は3群ほぼ6割で副作用による中止例は80mg群の1例のみで, 安全度において3群間に有意差はなかった.主な副作用は乳房腫脹, 乳房圧痛等であったTo investigate the efficacy and safety of bicalutamide (Casodex(R)) with its clinically recommended dose, the randomized early phase II study was performed in 124 patients with prostatic cancer (stage C, D). The patients were given 50, 80 or 100 mg of bicalutamide orally once a day in fixed doses for 12 weeks ; 122 patients were eligible for evaluation. The overall response rate was 50.0% (20/40); 61.0% (25/41) and 53.7% (22/41) in the 50 mg, 80 mg and 100 mg groups, respectively. The response rate in prostate lesion, bone and lymph node metastases was slightly higher in the 80 mg group than in the 50 mg and 100 mg groups. The proportion of patients showing a response with regard to serum PSA (CR and PR) was 84.2, 92.7 and 97.6% in the 50, 80 and 100 mg groups, respectively. The incidence of adverse reactions was 65.0, 61.0 and 61.0% in the 50, 80 and 100 mg groups, respectively, and there was no significant difference in overall safety rating in the three groups. Frequent adverse reactions were gynecomastia and breast pain. Only one patient in the 80 ing group was withdrawn due to shortness of breath. Serum concentrations of LH, testosterone and estradiol increased significantly after treatment. Bicalutamide was concluded to be effective and well tolerated in patients with prostatic cancer, and its recommended dose was 80 mg once daily