A Modified PGSS Process：Encapsulation of CoQ10 and Menthol

气体饱和溶液成粒技术（PGSS）是近几年发展起来的一种新型的超临界微粒化/微胶囊化技术。相比于传统方法，该方法工艺简单、操作费用低且无污染，可以对颗粒大小、分布以及微胶囊芯材包裹率进行比较方便的调控。本文研究内容包括PGSS工艺的改进及其在微粒化和微胶囊化（包括药物和香料）的应用。 设计和搭建了一套改进的PGSS装置，相比于已报导的PGSS工艺，该装置具备如下优点：可以自由进行N2与CO2之间的切换和N2与CO2的混用；设计双通喷嘴可以防止物料在喷嘴中堵塞，还能增加雾化效果；设计饱和液体循环结构，可以加快熔融液体与超临界流体较快地形成气体饱和溶液，还能加剧该饱和液体的搅动，使制备的微粒/微胶...PGSS (particles from gas-saturated solution) is a promising supercritical fluid (SCF)-assisted technique in preparing fine particles and microcapsules /microspheres. PGSS technique has some significant advantages over traditional methods in preparation of fine particles such as low energy comsumption, environment-friendly process, preferable particle morphology, and controllable particle size and ...学位：工学硕士院系专业：化学化工学院化学工程与生物工程系_化学工程学号：2062006115202

基于公共特征空间的自适应情感分类

针对情感分类这一项从文章或句子中得到观点态度的任务,常规情感分类模型大多需要耗费大量人力获取标注数据.为解决某些领域缺乏标注数据,且其他领域分类器无法在目标领域直接使用的现状,设计了一种新颖的基于构建公共特征空间方法,使分类模型可从有标注领域向无标注领域进行迁移适应,减少人工标注的成本开销,实现情感分类的领域自适应.该方法以大规模语料下预训练的词向量信息作为以词为元素的特征,在同种语言中表达情感所采用的句法结构相似这一假设前提下,通过对领域内特有的领域特征词进行替换的方式构建有标注数据集与无标注数据集基本共有的公共特征空间,使有标注数据集与无标注数据集实现信息共享.以此为基础借助深度学习中卷积神经网络采用不同尺寸卷积核对词语不同范围的上下文特征进行抽取学习,进而采用半监督学习与微调学习相结合的方式从有标注数据集向未标注数据集开展领域自适应.在来自京东与携程共5个领域的真实电商数据集上进行实验,分别研究了领域特征词选择方法及其词性约束对领域间适应能力的影响,结果表明:相较于不采用领域适应的模型,可提升平均2.7%的准确率;且在来自亚马逊电商的公开数据集实验中,通过与现有方法进行对比,验证了该方法的有效性.国家重点研发计划资助项目(2018YFC0830300);;福建省科技计划资助项目(2018H0035);;厦门市科技计划资助项目(3502Z20183011);;掌数金融科技研发基金资助项目~

Arts in the Small Community: Essays and Supplements Celebrating the 50th Anniversary of Arts in the Small Community: A National Plan

The Arts in the Small Community: Essays and Supplements Celebrating the 50th Anniversary of The Arts in the Small Community: A National Plan. Eight essays and fourteen supplements from the original project provide the intellectual framework and the practical exploration of empowering arts in democratic America. The 1966 version is the original National Plan, while the 2006 version includes the stirring language of the original, but recognizes all of the dramatic progress in community arts development that took place between 1966 and 2006. It was intended to be a do-it-yourself manual to help local arts activists focus their work.https://engagedscholarship.csuohio.edu/msl_ae_ebooks/1002/thumbnail.jp

Effect Analysis of Helicobacter Pylori Eradication

目的从幽门螺杆菌(HElICObACTEr PylOrI,H.PylOrI)根治的疗效角度,探讨影响H.PylOrI治疗的可能因素,以期为临床合理用药提供依据。方法对本院2010年1月—2011年9月经胃镜尿素酶检查和(或)13C-呼气试验检测H.PylOrI阳性患者的治疗情况进行随访,收集H.PylOrI治疗结果并进行统计、分析。结果患者资料完整者共502例,H.PylOrI总体根除率为60.76%,其中男性根除率为66.67%(164/246),女性根除率为55.08%(141/256),不同性别H.PylOrI根除率比较,差异有统计学意义(χ2=7.066,P0.05)。本研究筛选出9种不同的H.PylOrI根治方案,其中以质子泵抑制剂(PPI)+铋剂(b)+克拉霉素(C)+左氧氟沙星(l)方案H.PylOrI根除率最高(为80.49%),PPI+b+l+替硝唑(TIn)的H.PylOrI根除率最低(为50.00%),两种方案H.PylOrI根除率比较,差异有统计学意义(χ2=7.570,P0.05)。7 d疗程方案者占63.75%,H.PylOrI根除率为63.44%,较其他疗程高,各疗程间H.PylOrI根除率比较,差异无统计学意义(χ2=3.294,P>0.05)。埃索美拉唑(ESO)与奥美拉唑(OME)方案H.PylOrI根除率比较,差异有统计学意义(χ2=7.839,P=0.005,检验水准调整值为0.008)。结论 H.PylOrI根除率与性别、治疗方案、PPI有关,与年龄、疗程无关。Objective To explore factors that affect the outcomes of Helicobacter pylori(H.pylori) eradication.Methods A total of 502 patients who were confirmed to be with H.pylori infection by Gastroscope urease and/or 13C-UBT in our hospital between January 2010 and September 2011 were enrolled in this study.The relevant data were collected and analyzed.Results The total eradication rate was 60.76%,in which the eradication rate was 66.67%(164/246)in males and 55.08%(141/256)in females(χ2=7.066,P0.05).Among the 9 therapeutic regimens,PPI+B+C+L achieved the highest eradication rate(80.49%),whereas PPI+B+L+Tin had the lowest one(50.00%)(χ2=7.570,P0.05).About 63.75% of the patients applied the 7-day regimen,and the the eradication rate was 63.44%,which was higher than other regimens.The eradication rates showed no statistical difference among different treatment cycles(χ2=3.294,P>0.05).The esomeprazole group and omeprazole group had significantly different H.pylori eradication rates(χ2=7.839,P=0.005).Conclusion The H.pylori eradication rate is related to gender,treatment scheme,and proton-pump inhibitors,but not to age and treatment cycle

Preparation of Tripalmitin Micronization by Supercritical Fluids Technique

利用气体饱和溶液微粒形成技术实验装置,分别用超临界n2和超临界CO2制备三棕榈酸甘油酯微粒,探讨压力、温度以及喷嘴大小等工艺参数对微粒(粒径、粒径分布和形貌)的影响。结果表明:n2辅助过程得到的微粒基本为球状;预膨胀压力越高,粒径越小,粒径分布越窄;100μM喷嘴下制得的微粒粒径最小,且分布较均匀。CO2辅助过程得到的微粒部分为球状,部分为针状和片状;预膨胀压力越高,粒径越小,粒径分布越窄;喷嘴直径大小对微粒平均粒径及粒径分布影响不大;预膨胀温度升高,颗粒的粒径稍微增大。CO2辅助过程得到的微粒粒径比n2辅助过程得到的微粒粒径稍大,但两者的粒径分布相差不大。Generation of tripalmitin microparticles from its melts was investigated by using both supercritical CO2 and supercritical N2.The effects of various operating conditions,such as the pre-expansion pressure,pre-expansion temperature,and nozzle size on the particle morphology,particle size and particle size distribution(PSD) were investigated.Results showed that microspheres were obtained from the N2-assisted process,the particle size decreased and PSD narrowed with the increasing of the pre-expansion pressure,nozzle size showed no obvious effect on the microparticles,and pre-expansion temperature should be less than 72 ℃ to obtain solid particles.From the CO2-assited process,spherical,lamellate and needle-like particles were obtained,the particle size decreased,PSD narrowed with the increasing of the pre-expansion pressure,nozzle size showed no obvious effect on the particles and the pre-expansion temperature slightly increased the average size of particles.Particles' PSD from supercritical CO2 was close to that from supercritical N2

LARGE-SCALE EXPOSITION PLANNING AND MANAGEMENT OPTIMIZATION BASED ON VISITORS' BEHAVIOR SIMULATION:A CASE STUDY of QINGDAO INTERNATIONAL HORTICULTURAL EXPOSITION 2014

2014年青岛世园会参观人次众多,需要对参观者行为进行模拟分析,以保证活动安全,提升游客体验。研究提出了通过行为模拟支持规划评价、预警及对策的技术框架。利用路径调查与陈述偏好调查获得参观者行为数据并建立模型,进而在多个情景下对个体行游轨迹进行了模拟仿真,分析预测了参观者排队、密度等参数的时空分布情况。在针对不同类型的评价对象提出各自评价指标的基础上,从模拟结果中辨识可能存在的问题,并从规划与管理两方面提出预警及优化对策。研究证明了对大型展会活动开展参观者行为模拟的技术框架的可行性,其结果对本次世园会具有一定的实践指导意义。It is necessary to simulate visitors' behavior in Qingdao International Horticultural Exposition 2014 for security and high-quality visitor experience due to the huge estimated pedestrian volume.This paper proposes a technical framework in purpose of supporting the assessment, early warning as well as countermeasures based on behavior simulation.Visitors' activity data are collected through a route choice survey and the informants' reported preference, based on which the behavior models are estimated.Visitors' trajectories under several scenarios are simulated, together with the spatio-temporal distributions of visitors' density and queuing behaviors.Criteria are proposed to evaluate each simulated object, based on which indexes are set up, used to identify problems that are likely to happen in the real exposition.In the end, the paper proposes early warnings and countermeasures of both planning and administration.The simulation framework is demonstrated to be feasible and valuable for the exposition.国家自然科学基金项目“基于行为分析的商业综合体空间优化方法研究”的部分成

Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids

VZV是一种广泛存在并且具有高度传染性的人类α-疱疹病毒。初次感染VZV可导致水痘，人群普遍易感（感染率约为61%～100%）。该病毒可在背根神经节潜伏感染，持续终生。夏宁邵教授团队长期开展VZV相关基础与新型疫苗研究，通过系统和精细探索建立了高效的VZV规模化培养和病毒颗粒纯化技术体系，成功获得高质量的VZV颗粒样品。首次揭示了疱疹病毒α家族的水痘-带状疱疹病毒（VZV）不同类型核衣壳的近原子分辨率结构，阐明了VZV核衣壳不同组成蛋白的相互作用网络与衣壳装配机制，可为进一步开展新型载体疫苗设计及抗病毒药物等研究提供重要支持。 我校博士后王玮、高级工程师郑清炳、博士生潘德全和俞海副教授为该论文共同第一作者，我校夏宁邵教授、程通副教授、李少伟教授以及美国罗格斯大学朱桦（Hua Zhu）教授、加利福尼亚大学洛杉矶分校周正洪（Z. Hong Zhou）教授为该论文的共同通讯作者。【Abstract】Varicella-zoster virus (VZV) is a medically important human herpesvirus that causes chickenpox and shingles, but its cell-associated nature has hindered structure studies. Here we report the cryo-electron microscopy structures of purified VZV A-capsid and C-capsid, as well as of the DNA-containing capsid inside the virion. Atomic models derived from these structures show that, despite enclosing a genome that is substantially smaller than those of other human herpesviruses, VZV has a similarly sized capsid, consisting of 955 major capsid protein (MCP), 900 small capsid protein (SCP), 640 triplex dimer (Tri2) and 320 triplex monomer (Tri1) subunits. The VZV capsid has high thermal stability, although with relatively fewer intra- and inter-capsid protein interactions and less stably associated tegument proteins compared with other human herpesviruses. Analysis with antibodies targeting the N and C termini of the VZV SCP indicates that the hexon-capping SCP—the largest among human herpesviruses—uses its N-terminal half to bridge hexon MCP subunits and possesses a C-terminal flexible half emanating from the inner rim of the upper hexon channel into the tegument layer. Correlation of these structural features and functional observations provide insights into VZV assembly and pathogenesis and should help efforts to engineer gene delivery and anticancer vectors based on the currently available VZV vaccine.This research was supported by grants from the National Science and Technology Major Projects for Major New Drugs Innovation and Development (no. 2018ZX09711003-005-003), the National Science and Technology Major Project of Infectious Diseases (no. 2017ZX10304402), the National Natural Science Foundation of China (no. 81871648, 81601762), the Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences (no. 2019RU022) and the US National Institutes of Health (DE025567/028583). 该研究获得了国家自然科学基金、新药创制国家科技重大专项和传染病防治国家科技重大专项等资助

Effects of Attentional Bias Training on Emotional Regulation in Methamphetamine Addicts

目的:探讨甲基苯丙胺成瘾者情绪状态的特点及注意偏向训练对其负性情绪的调节作用,为预防复吸提出理论依据和实证经验。方法:以116例甲基苯丙胺成瘾者为研究对象,通过施测正性负性情绪量表(the positive and negative affect scale, pANAS),来分析甲基苯丙胺成瘾者的情绪加工特点,采用点探测任务对甲基苯丙胺成瘾者的情绪进行注意偏向训练,比较训练结束后、训练结束1周后、训练结束1个月后对其负性情绪的影响。结果:甲基苯丙胺成瘾者的负性情绪显著高于常模(t=-15.103, P<0.01)效果仍然显著。结论:甲基苯丙胺成瘾者具有与常人显著不同的负性情绪加工特点,注意偏向训练能够有效地改善其负性情绪,且调节效果可达1个月之久。研究结果为预防复吸提供了有效且无损伤的心理学训练方法

新加坡华人平翘舌音的识别和产出 = Chinese Singaporeans' phonological discrimination and articulation of blade alveolars and retroflexes

这项研究旨在调查新加坡华人平翘舌音[t͡s]、[t͡sʰ]、[s] 和[ʈ͡ʂ]、[ʈ͡ʂʰ]、[ʂ] 的辨别能力以及发音方式。本次研究所设的听辨实验要求受试者区分两个听起来相似的词，两者的差别在于一个是平舌音，另一个是翘舌音。通过此实验，受试者平翘舌音的辨别能力得到了检验。研究结果显示受试者更擅长辨别翘舌音。之后,本次研究通过使用单因素ANOVA 和 t-检验探讨社会因素对受试者平翘舌音的辨别能力是否有显著性的影响。结果显示，年龄、性别和教育水平对此有显著的影响。此外，这项研究结合了经典拉波夫社会语言学的测试法例如,(1)按语音相似度排列的单词表，(2)随意排列的单词表和(3)阅读短文,以探讨新加坡华人平翘舌音的发音情况。ANOVA 和 t-检验的结果表明，年龄、性别、教育水平和方言的使用频率对受试者平翘舌发音有显著的影响。其次，本文通过结合前两项研究实验的结果，探讨辨别能力与发音方式之间的相关性。最后，本文讨论了所发现语言现象背后的可能原因，以及对新加坡汉语拼音教学的启示。This study investigates the phonological discrimination skills and articulation of Chinese Singaporeans with respect to blade alveolars [t͡s]、[t͡sʰ]、[s] and retroflexes [ʈ͡ʂ]、[ʈ͡ʂʰ]、[ʂ] in Mandarin Chinese. Participants performed a series of tasks to distinguish between two similar-sounding words, and their discrimination abilities were examined. Results showed that participants were better at identifying retroflexes than blade alveolars. ANOVA and t-tests were used to assess the significance of social factors on participants' discrimination abilities, with age, gender and education level found to have a significant effect. The study also used classic Labovian methods such as minimal pair lists, word lists and reading passages to investigate the impact of social factors on pronunciation. Results revealed that age, gender, education level, and frequency of usage of Chinese dialects significantly influenced pronunciation. Additionally, the study examined the correlation between phonological discrimination skills and articulation. The final section discusses the reasons for the observed phenomena as well as pedagogical implications of the above findings. It is in hope that this research will provide a deeper insight of the usage and understanding of blade alveolars and retroflexes in Singapore, building upon previous studies.Bachelor of Arts in Chines

基于区块链与函数加密的隐私数据安全共享模型研究

区块链技术给数据共享中的数据确权、数据溯源、数据可信、数据可用等方面提供了新思路，但数据共享中的隐私数据安全仍面临许多挑战。首先回顾当前基于区块链的数据共享研究现状；然后提出一种隐私数据安全共享模型，通过函数加密技术对隐私数据进行加密，结合零知识证明技术生成相关计算的可信证明，实现“数据可用不可见”的安全可靠的数据共享。实验结果显示，该模型的共享时延及经济开销均在可接受范围内，证明了该模型的安全性和可行性