变精度多粒度粗糙集近似集更新的矩阵算法

随着信息大爆炸时代的到来,数据集的巨大化和数据集结构的复杂化已经成为近似计算中不能忽视的问题,而动态计算是解决这些问题的一种行之有效的途径。对现有的应用于经典多粒度粗糙集动态近似集更新方法进行了改进,提出了应用于变精度多粒度粗糙集(VPMGRS)的向量矩阵近似集计算与更新方法。首先,提出了一种基于向量矩阵的VPMGRS近似集静态计算算法;其次,重新考虑了VPMGRS近似集更新时的搜索区域,并根据VPMGRS的性质缩小了该区域,有效地提升了近似集更新算法的时间效率;再次,根据新的搜索区域,在VPMGRS近似集静态计算算法的基础上提出了一种新的VPMGRS近似集更新的向量矩阵算法;最后,通过实验验证了所提算法的有效性。国家自然科学基金资助项目(11871259,61379021);国家自然科学基金青年项目(11701258)~

变精度多粒度粗糙集近似集更新的矩阵算法

随着信息大爆炸时代的到来,数据集的巨大化、数据集结构的复杂化已经成为近似计算中一个不能忽视的问题。动态计算是解决这些问题的一种行之有效的途径。本文对现有的应用于经典多粒度粗糙集动态近似集更新方法进行了改进,提出了应用于变精度多粒度粗糙集的向量矩阵近似计算与更新方法。首先,提出了一种基于向量矩阵的变精度多粒度粗糙集的近似集静态计算算法；其次,重新考虑了变精度多粒度粗糙集近似集更新时的搜索区域,并根据变精度多粒度粗糙集的性质缩小了该区域,这能有效地提升近似集更新算法的时间效率；再次,根据新的搜索区域,在变精度多粒度粗糙集近似集静态计算算法的基础上,提出了一种新的变精度多粒度粗糙集近似集更新的向量矩阵算法；最后,进行实验验证了本文提出的算法的有效性

2018年安溪珠塔内窑调查报告

2018年5月至7月,厦门大学历史系考古专业、福建博物院文物考古研究所及安溪县博物馆等单位联合组成\"安溪古窑址调查队\",对安溪珠塔内窑进行了全面的调查,基本了解珠塔内窑古窑址分布与保存情况,采集了一批明末清初的青花瓷器、白瓷与窑具标本,并发现部分窑炉遗迹,为研究闽南地区青花瓷窑业发展提供了第一手资料

Exploring mechanisms of Salmonella-induced reduction of cancer metastasis

Metastasis is responsible for 90% death of cancer patients. Long-term dormancy, genetic heterogeneity, drug resistance and multiple growths all contribute to the lethal feature of metastasis. We have successfully engineered a tumor-hypoxia targeting Salmonella typhimurium strain YB1 for cancer therapy. Administration of YB1 to 4T1 tumor-bearing BALB/c mice partially inhibits the growth of primary tumor, but significantly reduces lung metastasis. Little is known about how bacterial treatment inhibits cancer metastasis. In this study, we aim at understanding the underlying mechanisms by investigating Salmonella-induced immune responses and their effects on metastasis. The overall process of metastasis includes localized invasion, intravasation, circulation, extravasation and colonization. Only Salmonella treatments taken prior to colonization could reduce lung metastasis. However, later treatment could not eliminate established lung metastasis. Experimental metastasis model further demonstrates that YB1 treatment interferes with the colonization process of cancer cells in lung, thus reducing metastasis. Both arms of immunity are investigated in this study. T cell frequency was quantified in tumor, metastatic tissue lung, spleen and tumor-draining lymph nodes after YB1 treatment. Surprisingly, dramatic reduction of CD3+ T cells in tumor was observed as early as one-day post YB1 treatment, while the number of CD3+ T cells in lung remains unchanged. In addition, significant decrease of CD4+ and CD8+ T cells was observed in spleen. A decrease of CD4+ T cells in tumor-draining lymph nodes was also detected, indicating that T cells may not be actively involved in reducing lung metastasis by functioning in tumor. Indeed, similar anti-metastasis efficacy can be observed in tumor-bearing immunodeficient NOD SCID mice treated with Salmonella, suggesting that the innate immunity in particular could be responsible for the reduction of lung metastasis. Treatment with Salmonella induces strong systemic and tumor-localized pro-inflammatory responses, as indicated by highly elevated cytokine levels of IL-1, IL-6 and TNF-α. Administration of immunosuppressive drug prednisolone to mice treated with YB1 partially impaired the anti-metastasis effect of YB1, implicating an important role of immune responses in mediating the reduction of lung metastasis. Much higher levels of IL-6, IL-12, IL-18, TNF-α and IFN-γ were observed in YB1-treated mice than E. coli- or heat-killed YB1-treated mice, which show no anti-metastasis effect. Depletion of IFN-γ but not TNF-α abolishes the anti-metastasis effect of YB1. However, when administrated alone, IFN-γ fails to inhibit metastasis, suggesting that IFN-γ is not sufficient to reduce lung metastasis and other factors may be involved. Our study highlights the importance of innate immunity in mediating the reduction of lung metastasis. Another important implication from our study is that stimulating the immune system would be effective in the prevention of metastasis. A particular cytokine response profile induced by Salmonella treatment, especially IFN-γ response, may be needed to interfere the process of metastasis.published_or_final_versionBiomedical SciencesDoctoralDoctor of Philosoph

大熊猫粪便皮质醇激素分布与取样对策

粪便皮质醇激素对衡量动物应激强度具有较好的指示作用,但其检测准确性受诸多因素影响。为了评估不同取样方式对大熊猫(Ailuropoda melanoleuca)粪便皮质醇测定产生的影响,将粪便横向纵向四等分分割,采用冻干研筛法与酶联免疫吸附法(ELISA)处理每部分粪便和测定激素含量,旨在分析粪便激素分布情况以进一步探讨取样对策。结果显示:每部分粪便的皮质醇含量无显著差异(df=3,F=0.033,P=0.992),粪便在四等分处理下的激素分布比较均匀,即每部分粪便激素均能在一定程度上代表整体水平。1/2取样所产生的变异系数小于1/4取样,前者的检测准确性更高。粪便湿重与尺寸大小存在显著正相关性(r=0.897,Py=2.3x-29.3(y为粪便湿重,x为粪便大小,R2=0.804,F=418.846,P<0.001)。粪便干重由粪便类型、尺寸和含水率决定。在野外工作中,建议采用纵向1/2的取样对策

病例180:78岁男性,头昏、周身乏力伴视物模糊1周

综合上述分析,面对这样一个同时合并大血管狭窄、心房颤动、蛋白尿、高Hcy的老年脑卒中个体,可以说,没有哪个指南和专家共识能够直接拿来指导治疗策略; 。必须综合考虑,权衡利弊,给予个体化的治疗。最终,拟将血压<150/90 mm; Hg作为该患者的目标血压。据此,给予联合应用beta受体阻滞剂、利尿剂和ARB进行治疗:美托洛尔缓释片23.75 mg,1次/d; +吲达帕胺2.5 mg,1次/d +坎地沙坦酯4; mg,1次/d,后坎地沙坦酯片加量至8mg,1次/d。患者2周后血压即控制在130~150/60~70 mm Hg,随访3个月,病情稳定