Study on response inhibition deficit serving as an endophenotype to ADHD

目的 探讨反应抑制能否作为注意缺陷多动障碍的认知内表现型.方法 运用反应/不反应任务、停止信号任务、Stroop色-字任务对100名注意缺陷多动障碍儿童和对照组儿童进行抑制功能测试,并收集注意缺陷多动障碍儿童的家族史.根据其家族史的有、无将注意缺陷多动障碍儿童分为家族史阳性组和家族史阴性组,运用多变量方差分析进行统计.结果 3组儿童在反应抑制功能上存在显著性差异[F(12,350)=7.916,P〈0.001,&eta;2=0.213],控制FIQ后仍有统计学意义[F(12,348)=6.658,P〈0.001,&eta;2=0.187].Bonferroni多重比较显示,在Stroop色-字测试反应时干扰及错误数干扰上,家族史阳性的注意缺陷多动障碍组儿童明显差于家族史阴性组,而后者又明显差于对照组儿童;在反应/不反应任务漏按键数、正确反应的反应时变异及停止信号任务的停止信号反应时上,两组注意缺陷多动障碍儿童明显差于对照组儿童,虽然两组注意缺陷多动障碍儿童间无显著性差异,但家族史阴性组表现介于家族史阳性组与对照组之间.结论 注意缺陷多动障碍儿童存在反应抑制功能缺陷;反应抑制可能是注意缺陷多动障碍的认知内表型之一.</p

Study on the delay aversion in childreh with attention deficit hyperactivity disorder

【目的】探讨注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童持续注意及反应抑制特征,为临床诊治提供参考依据。【方法】运用持续注意反应任务(SART)对100名ADHD儿童及对照组儿童进行测试,采用多变量方差分析/协方差分析对持续注意及反应抑制能力进行统计。【结果】总的来说,两组儿童在持续注意及反应抑制功能上差异有统计学意义(P<0.001)上明显地多于对照组儿童,所需反应时(P【Objective】 To determine the characteristics in cognitive domain of sustained attention and response inhibitionl domain children with attention deficit hyperactivity disorder（ADHD）.【Methods】 One hundred children with ADHD and 100 healthy controls matched in age,gender,grade,handedness were measured with sustained attention response to task（SART） involing ability of suatained attention and response inhition.The performance was compared using multivariate analysis of variance（MANOVA） and MACOVA with FIQ controlled for between two groups.【Results】 The omnibus MANOVA of the primary neuropsychological variables revealed a large group effect with P0.001.The ANOVAs of each index showed that children with ADHD made more omission errors（P=0.004） and commission errors（P0.001） than did healthy controls.Furthermore,the reaction times（RT） of correct response（P0.001） in children with ADHD were much longer than that in healthy controls,and the variability of RT much more than the latter（P=0.001）.The results remainded unchanged arter controlling for FIQ.【Conclusion】 There are significant deficits of sustained attention and response inhibition in children with ADHD

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies