Snail regulates hepatocellular carcinoma orphan nuclear receptor Nur77 promoter methylation

Nur77隶属于类固醇/甲状腺/视黄酸核受体超家族，在细胞增殖、凋亡过程以及肠癌、黑色素瘤的发生发展中发挥着重要的作用。但是，有关Nur77与肝癌的研究却比较少。基于Oncomine数据库信息，本文研究发现，在临床组织样品中，癌旁组织中Nur77的表达远远高于对应肝癌组织中的表达。我们从基因修饰入手，通过甲基化抑制剂ADC梯度给药实验最终将目标指向DNA甲基化。通过序列比对我们发现，Nur77启动子上含有转录抑制因子Snail特异性结合的E-box结构（CAGGTG）。通过构建稳转过表达或者敲低Snail的肝癌细胞，Nur77在mRNA水平、蛋白水平及其启动子活性都与Snail呈现一种负相关变...Nur77 is a member of the steroid/thyoid/retinoid nuclear receptor superfamily. Although it plays an important role in cell proliferation, apoptosis, development of colon cancer and melanoma, there is less study focused on Nur77 and hepatocarcinoma. Based on the Oncomine Database information, we found that the expression of Nur77 in para-carcinoma is higher than that in paired carcinoma in clinical...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162014115248

Analysis of Monetary Policy Transmission Mechanism in Our Country

货币政策是一国政府宏观调控的主要工具，而货币政策是否有效，关键在于其传导机制是否畅通。货币政策传导机制是指由中央银行信号变化而产生的脉冲所引起的经济过程中各中介变量的连锁反应，并最终引起实际经济变量变化的途径。它自中央银行启动货币政策工具开始，引发金融领域和真实领域中某些变量的一些变化，并且最终趋向货币政策目标。 货币政策传导机制具有很强的时空性和动态性，自1998年以来，中国的社会主义市场经济体制逐步建立，对外开放程度进一步提高，金融市场不断深化，金融工具种类大大增加。从这一年起，中国的宏观调控机制由直接调控逐步向间接调控转变。窗口指导、再贷款和利率都成了主要的货币政策工具，频繁运用窗口指...Monetary policy plays an important role in the country's macro-control, and whether monetary policy will take into effect lies in whether its transmission is smooth. Monetary policy transmission system is a way to ultimately generate changes of the real economic variables by a chain reaction of the intermediate variables in the economic process which is caused by the changes of central bank. It st...学位：经济学硕士院系专业：经济学院财政金融系_金融学(含保险学)学号：1562008115206

Material and Energy Conversion of Integrated 100,t/a-Scale Bio-Jet Fuel-Range Hydrocarbon Production System via Aqueous Conversion of Biomass

以农业废弃物生物质为原料，利用水相转化技术，进行了百吨/年规模生物航油类烃(C8~C15)合成试运行.过程中采用两步酸解法分别将玉米秸秆中半纤维素和纤维素转化为糠醛和乙酰丙酸，作为生物质基平台化合物.在碱性条件下糠醛与乙酰丙酸经Aldol缩合反应实现碳链增长，生成的长链含氧中间体经过低温预加氢、高温加氢脱氧及精制，生成C8~C15范围内液态烃，可作为生物航油组分.以试运行实验结果为基础，进行了过程的物质与能量转化分析.结果表明，该路线获得液态烃类的基本性质满足合成航油ASTM-7566标准要求，并充分利用了原料中纤维素和半纤维素组分，是一条基于生物质的长链液态烃合成路线，1t航油约需10~12t干基玉米秸秆

Preparation of Supported Palladium Catalyst by Bioreduction

［中文文摘］将微生物可在常温下还原贵金属离子的特性引入催化剂的制备过程中,利用对Pd2+具有较强还原能力的地衣芽孢杆菌(简称R08)制得负载型Pd催化剂(简称催化剂)。采用X射线光电子能谱(XPS)和透射电镜(TEM)对催化剂进行表征。XPS测定结果表明,室温下R08菌体可将γ-A l2O3载体表面上的Pd2+基本还原为Pd0;生物还原法制得的催化剂的Pd微粒的平均粒径约为5nm。将该催化剂用于2%CO-98%空气(体积分数)混合气的催化氧化反应,CO完全氧化的最低反应温度为60℃,在此温度下催化剂的活性可恒定150h,结果优于相同条件下化学浸渍法制得的催化剂。XPS表征和催化活性评价结果说明,用于CO催化氧化反应的催化剂中单原子Pd活性中心的价态为0~+2。［英文文摘］Pd catalyst supported on γ2a lumina ( nanoparticles) with high dispersion was prepared by bioreduction with Bacillus lichenifoum is ( strain R08) , which was strong in reducing ab ility of Pd2 + . Catalysts prepared by bioreduction and impregnation were cha racte rized by m eans of XPS and TEM.XPS spectra indicated tha t s train R08 could almost completely reduce Pd2 + to Pd0. TEM images showed that average sizes of Pd particles on catalysts prepared by bioreduction and by impregnation were 5 nm and 18 nm, respectively. When catalyst p rep ared by bioreduc tion w as used in ox idization of carbon m onoxide to carbon dioxide, the carbon monoxide could be comp letely oxidized at the lowest temperature of 60 ℃and activity of catalyst could be main tained a t this tempe rature fo r 150 h. The result was better than catalyst prepared by imp regnation. Pd ( Ph2 PCH2 PPh2 ) 2 suppo rted on γ2alum ina was synthesized as catalyst for the oxidation. Results of XPS spectra and activity eva luation indicated that chemical valence state of Pd on active center of catalyst was between 0 and + 2.国家自然科学基金项目(20376067

Temperature Programmed Decomposition of NO over Er 2O 3/Bi 2O 3 Catalysts

nOX是造成大气污染的化学物质之一，因此，消除nOX是环境保护的一项重要任务.目前比较成熟的消除nOX工艺是用氨为还原剂和V2O5/TIO2为催化剂的选择催化还原（SCr）法［1］，但其成本过高.其后发展了用CH4等低碳烷烃作还原剂，在O2共存下用C...The Face centered cubic(Fcc) phases of n (Er 2O 3)/ n (Bi 2O 3)=5%￣40%, molar Fraction) which is an oxygen ion conductor were prepared.The decomposition of NO over these Er 2O 3/Bi 2O 3 catalysts was examined by means of temperature programmed surFace reaction.The results showed that the surFace adsorbed NO decomposed to N 2 and O 2 at ca.600 ℃.The plot of NO conversion and Er composition showed that there was an optimum decomposition rate at ca.23%(molar Fraction).Comparing to the data of conductivity, one can conclude that the rate of NO decomposition increases with the increase in the number of oxygen vacancies.This has been contributed to the similar electronic structure between O 2 and NO.国家自然科学基金;香港研究基

提高CO_2加氢合成甲醇选择性和收率的一种方法

提高CO2加氢合成甲醇选择性和收率的一种方法李基涛张伟德付金印古萍英（厦门大学化学系物理化学研究所361005）区泽棠（香港浸会大学化学系九龙塘）关键词CO2加氢合成甲醇CO的作用提高选择性和收率随着工业发展和人类利用石化能源的增加，大气中CO2浓度...香港浸会大学科研基金;厦门大学固体表面物理化学国家重点实验

V_2O_5/MPO_4在丙烷氧化脱氢中的催化作用

研制了具有不同酸碱性的磷酸盐ＭＰＯ４（Ｍ＝Ａｌ，Ｚｒ，Ｃａ）载体，并用这些载体负载０６％～６０％的Ｖ２Ｏ５。所制备的催化剂在丙烷氧化脱氢反应中具有较好的催化性能，如３％Ｖ２Ｏ５／Ｃａ３（ＰＯ４）２催化剂在丙烷转化率为１７０％时，丙烯选择性可达５５９％，丙烯收率达９５％。考察了不同反应条件下催化剂的性能，表明在高温高空速条件下，３％Ｖ２Ｏ５／Ｃａ３（ＰＯ４）２催化剂的反应活性较好，而３％Ｖ２Ｏ５／Ｚｒ３（ＰＯ４）４催化剂在低温低空速时，反应活性相对较高。在相同的丙烷转化率下，丙烯的选择性从大到小的顺序为３％Ｖ２Ｏ５／Ｃａ３（ＰＯ４）２＞３％Ｖ２Ｏ５／Ｚｒ３（ＰＯ４）４＞３％Ｖ２Ｏ５／ＡｌＰＯ４

Oil Spill identification by near-infrared spectroscopy coupled with clustering analysis based on principle components

鉴于目前没有一种方法能独立解决溢油鉴别的所有问题,本文提出了近红外光谱技术结合主成分聚类分析鉴别溢油种类的方法。通过有机溶剂萃取出自行配制的汽油、柴油和润滑油模拟样品中的溢油后记录其近红外光谱,对5800～6200cm-1区段范围内的谱图经多元散射校正(MSC)、Norris一阶导数平滑预处理处理后求其主成分,并在主成分的基础上引入Ward聚类分析法(离差平方和法)对样品分类。结果表明近红外光谱技术结合聚类分析能对体积分数在0.4～0.8mL/L间的海面溢油样品正确、快速分类,近红外光谱技术结合主成分聚类可作为溢油鉴别的一种辅助方法。Owing to none of the existing method can do it all for oil identification, but a method by near-infrared spectroscopy (NIR) coupled with clustering based on principle components is proposed. Petroleum oil stimulating samples of gasoline, diesel fuel and lubricating oil were employed to develop the method. NIR spectra ranges of 5800～6200cm~(-1) were recorded with the multiplicative signal correction and Norris first derivative filter pretreatments. The clustering analysis by Ward's method base on the different principle components was discussed. The results show that the method provides the rapid and accurate classification for spilled oil with concentration between 0.4～0.8 μL/L.国家高技术发展计划(863)资助项目(2001AA635040

The Preparation of Silver Nanoparticles

［中文文摘］在简要介绍纳米银在各个工业领域应用的基础上,总结比较了各种制备纳米银颗粒的方法。物理和化学方法的工艺技术都比较成熟,但也存在着一定的不足。新兴的生物还原法因其具有微生物原料来源广,生物还原反应条件温和,产物纳米颗粒不易团聚,以及过程加入的化学试剂和产生的有毒副产物少等特点而开始受到关注。微生物还原金属离子有2种不同的机理:微生物的酶催化机理和非酶还原机理。对生物还原法原理的充分认识是将该方法发展成为可实际应用的纳米银制备工艺的重要基础。［英文文摘］The main applications of silver nanoparticles in industry were briefly reviewed in the present paper. The methods used for preparation of silver nanoparticles were summarized and compared. The physical and chemical methods are relatively mature but they have some shortcomings. The biological method is recently developed as a promising method because of its special advantages such as sufficient material sources, mild reaction conditions, good dispersion of nanoparticles as well as few chemical addictives and poisonous byproducts. The biological method for preparation of silver nanoparticles included two mechanisms, namely enzymatic catalysis mechanism and non-enzymatic reduction mechanism. The full understanding of two mechanisms would be necessary for developing it into a practical process to prepare silver nanoparticles.国家自然科学基金(20376076); 中国石油化工股份有限公司项目(0041-K81042)

Progress in the studies of vivipary in mangrove plants

【中文摘要】植物胎生是指有性繁殖产生的后代在母体上直接萌发的现象, 在红树植物中最为常见。红树植物生长在热带亚热带海岸潮间带, 耐受高盐、高温、淹水缺氧和海浪冲击等复杂环境。胎生被认为是红树植物对这种特殊生境的重要适应方式。 该文从形态发育、生理生化、分子水平、生态适应4个层次讨论红树植物胎生现象对复杂生境的适应性, 并指出现有研究存 在的不足, 对将来的研究方向进行了展望。与非胎生胚胎发育相比, 红树植物胎生是一个遗传的程序, 在进化过程中形成了 一些特殊的结构。植物激素对胎生发育起关键的调控作用, 繁殖体发育过程中, 其盐离子的种类与浓度的动态变化则是对海 岸潮间带生境的重要适应特征。这种胎生繁殖体依靠在母体上完善的一系列功能性特征能更有效地适应落地后的滩涂环境。 然而, 红树植物胎生发育过程的分子机理及调控机制还有待研究。理解胎生这一特殊适应性现象的本质及其进化过程将为红 树林保护繁育、适应气候变化提供理论依据。 【Abstract】Vivipary in plants refers to a phenomenon that sexually reproduced offsprings germinate while still attached to the maternal bodies. This is mostly manifested in mangrove plants, which occur in tropical and subtropical intertidal zones and encounter harsh environmental conditions such as high salinity, high temperatures, waterlogging, hypoxia and tidal waves. Vivipary has long been recognized as one of the most important adaptive features under such a complex environment. Here we discuss four aspects of vivipary: morphological anatomy, physiology and biochemistry, molecular biology and ecological adaptation. We also discuss shortcomings in current studies and prospect of future directions. Differing from regular seed development, viviparous seeds in mangroves are evolved with many special structures, indicating a genetically based process. Hormones play an important role in regulating the process, whilst the dynamics of salt ion concentration during embryo and propagule development seems to be an adaptive feature. The ecological significance of vivipary is fully exhibited in the propagules that can effectively establish themselves on muddy tidal zones. Such a success heavily relies on sound functional features developed on the mother plants. However, the molecular mechanism and the regulation of viviparous seed development in mangroves remain elusive. Systematic studies of vivipary in mangroves not only help to understand the nature and evolutionary process of this distinct adaptive phenomenon, but also provide the foundation for mangrove forest restoration and protection in many parts of the world.福建省对外合作项目(2016I0013