Effects of Hemocoagulase Agkistrodon for Hemostasis in Surgical Tresis Vulnus: A Meta-analysis

目的:评价尖吻蝮蛇血凝酶(HCA)对手术创口的止血效果。方法:计算机检索Pub MEd、CbM、中国知网、维普和万方等数据库,收集采用HCA治疗手术创口出血的临床随机对照试验(rCT),并追溯纳入研究的参考文献。由2位评价者按照纳入排除标准独立筛选文献、提取资料和评价质量后,采用rEV MAn 5.2软件进行META分析。结果:纳14篇文献,共1 382个患者。META分析结果显示:与对照组比较,HCA可明显减少患者手术切口创面出血量[Md=-1.67,95%CI(-2.04,-1.30),P<0.000 1],减少术后引流量[Md=-19.10,95%CI(-25.96,-12.25),P<0.000 01],减少切口单位面积出血量[Md=-0.05,95%CI(-0.08,-0.03),P<0.000 01],缩短止血时间[Md=-50.67,95%CI(-74.85,-26.49),P<0.000 1]。结论:术前给予尖吻蝮蛇血凝酶能明显减少手术患者切口创面出血量、术后引流量和切口单位面积出血量,并缩短止血时间,但本研究仍有局限性,需大样本、多中心、随机对照临床试验进一步证实。Objective: To review the effects of hemocoagulase agkistrodon( HCA) for hemostasis in surgical tresis vulnus.Methods: Databases including Pub Med,CBM,CNKI,VIP and Wanfang were searched electronically to collect literature published.Randomized controlled trials( RCTs) were identified about HCA for hemostasis in surgical tresis vulnus.References of the included studies were also retrieved.Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assess the quality of the included studies.Then Meta-analysis was performed using Rev Man 5.2 software.Results: Fourteen trials involved 1 382 patients were included.The results of Metaanalysis indicated that,using HCA for hemorrhagic volume in surgical tresis vulnus[MD =- 1.67,95% CI(- 2.04,- 1.30),P < 0.000 1 ],drainage volume after the operation[MD =- 19.10,95% CI(- 25.96,- 12.25),P <0.000 01],hemorrhagic volume per square unit[MD =- 0.05,95% CI(- 0.08,- 0.03),P < 0.000 01] significantly decreased in comprison with blank control,hemostatic time[MD =- 50.67,95% CI(- 74.85,- 26.49),P < 0.000 1]were significantly shorten with blank control.Conclusion: HCA administered preoperatively could significant reduce the hemorrhagic volume,drainage volume after the operation,hemorrhagic volume per square unit and shorten hemostatic time compared with blank control in surgical patients.However,due to limitations of the included studies,the clinical effects need to be confirmed by large multicenter randomized controlled trials

高性能隧道防火涂料的产业化推广

鉴于隧道火灾特点及其危害性,隧道防火的重要性与日俱增。涂装隧道防火涂料是隧道防火的有效方法,文中简述了隧道防火涂料的防火机理,研制原则及制备流程。福建省防火阻燃材料重点实验室开展隧道防火涂料的研制,项目产品DP-3型混凝土隧道防火涂料完成在厦门大平公司的中试,并投入市场,产生良好的社会、经济效益,实现了隧道防火涂料成果产业化推广。该涂料已应用于数十项隧道工程的防火涂装,均一次性通过项目验收,获得优良评价

Experimental study on reperfusion of intraocular lens

作者简介: 祁明信, 男, 1945 年7 月 出生, 教授、主任医师、博士研究生 导师, 主要从事白内障的基础与临 床研究。联系电话: 0591-83570887; E-mail:qihuang@netease. com 通讯作者: 黄秀榕,E-mail:[email protected][中文文摘]目的开展晶状体再灌注的离体和动物实验研究,并对再灌注人工晶状体技术进行评价。方法采用新鲜离体幼兔眼、离体猪眼、新西兰白兔眼,应用自行研制的人工晶状体材料,进行以下实验:(1)体外固化实验;(2)晶状体前囊膜微型撕囊及其稳固性实验;(3)经微型前囊膜开口超声乳化吸出晶状体内容物实验;(4)活的新西兰白兔眼内人工晶状体再灌注实验。结果(1)按硅酮聚合物与固化剂50:1的比例可获得柔软、弹性好、固化时间短(完全固化时间为60min)的注入材料;(2)晶状体前囊膜1.8～2.0mm的连续环形撕囊口具有较好的稳定性,可经该微型开口吸出晶状体内容物并灌注材料;(3)超声能量18%、流量25mL·min-1、负压120mmHg(1kPa=7.5mmHg)为晶状体内容物经微型前囊膜开口吸出的最佳条件;(4)注入灌注材料后可形成由晶状体囊膜包裹的、置换原晶状体皮质和核的、新的再灌注人工晶状体。结论采用再灌注人工晶状体的方法可进行新型人工晶状体再灌注,可为治疗白内障和老视提供参考。[英文文摘]Objective To carry out the experimental study on reperfusion of intraocular lens(IOLs) in vitro or in animal,and to assess the technique of IOLs reperfusion.Methods The following experiments were performed by using self-developed materials in fresh rabbit eyes and pig eyes in vitro,as well as in eyes of alive New-Zea-land rabbits:(1)Solidification study of self-developed material in vitro;(2)Continuous circular capsulorhexis(CCC) in anterior capsule of lens and its stability;(3)Draw of lens contents via phaco through mini-CCC;(4)IOLs ref illing in the eyes of alive New-Zea land rabbits. Results(1) Thematerialwhich was soft, springy and short-term solidification(full solidification time was 60 minutes) were obtained in certain proportion of geland solidified agent(50:1) in vitro; ( 2)The CCC in anterior capsule of lens with 1.8-2.0 mm diameter had very good stability. The lens contents were drawn and the materialwere refilled through themini-CCC; (3) The best conditions of drawing out lens contents through m ini-CCC were phaco energy 18% , flow 25 mL·min- 1, and negative pressure 120 mmH g (1kPa=7.5 mmHg);(4) The new refilled IOLs, which were wrapped by capsule of lens and were replaced original cortex and nucleus of lens, were obtained after thematerial refillied. Conc lusion. New IOLs are refilled through this method, which can prov ide reference for the treatment of cataract and presbyopia.福建省科技三项费用;教育厅重点资助项目基金资助(编号:K98041

短臂型空气阴极微生物燃料电池产电特性研究

用夹子将质子交换膜和载铂量为0.2 mg/cm^2碳纸固定在阳极室的短臂端口构成短臂型空气阴极微生物燃料电池.利用污泥电池从厌氧消化污泥中富集产电菌于石墨棒表面,循环伏安法检测发现这些微生物具有电化学活性.将富集好的石墨棒作为阳极用于短臂型空气阴极微生物燃料电池,以醋酸钠为底物时该电池的最大功率密度为738 mW/m^2,内阻为280Ω,开路电压为741 mV.连续向阳极室通氮气和去掉质子交换膜可分别将电池的最大功率密度提高到745 mW/m^2和759 mW/m^2,当两者同时作用时最大功率密度可达到922 mW/m^2,而这3种条件下电池的内阻仍保持在280Ω左右.当底物浓度在12.62～100.96 mg/L、外电阻为510Ω时,电池的最大输出电压和底物浓度之间存在明显的线性关系（R^2=0.99）.当底物浓度高于100.96 mg/L时,电池的最大输出电压不再增大并保持在302 mV（外电阻为510Ω）.然而,电池的库仑效率则随着底物浓度的提高而提高,从31.83%逐渐增大到45.03%

短臂型空气阴极微生物燃料电池产电特性研究

用夹子将质子交换膜和载铂量为0.2 mg/cm2碳纸固定在阳极室的短臂端口构成短臂型空气阴极微生物燃料电池.利用污泥电池从厌氧消化污泥中富集产电菌于石墨棒表面,循环伏安法检测发现这些微生物具有电化学活性.将富集好的石墨棒作为阳极用于短臂型空气阴极微生物燃料电池,以醋酸钠为底物时该电池的最大功率密度为738 mW/m2,内阻为280Ω,开路电压为741 mV.连续向阳极室通氮气和去掉质子交换膜可分别将电池的最大功率密度提高到745 mW/m2和759 mW/m2,当两者同时作用时最大功率密度可达到922 mW/m2,而这3种条件下电池的内阻仍保持在280Ω左右.当底物浓度在12.62~100.96 mg/L、外电阻为510Ω时,电池的最大输出电压和底物浓度之间存在明显的线性关系(R2=0.99).当底物浓度高于100.96 mg/L时,电池的最大输出电压不再增大并保持在302 mV(外电阻为510Ω).然而,电池的库仑效率则随着底物浓度的提高而提高,从31.83%逐渐增大到45.03%

A study on depression-and anxiety-like behavior in left-and right-handed mice

目的通过小鼠模型来研究利手是否与抑郁和焦虑样行为有关。方法利用利爪行为测定装置测试了20只C57BL/6J雄性小鼠,共得到12只有明显用爪偏好的小鼠,其中左利爪6只,右利爪6只,对其进行自发活动和强迫游泳以及高架十字迷宫行为测试,观察两组小鼠在各项测试中的表现。结果自发活动测试显示左右利爪小鼠的移动距离和时间差异均无统计学意义;强迫游泳实验中左右利爪小鼠的不动时间的差异无统计学意义;高架十字迷宫实验中,左利爪小鼠进入开放臂的时间明显比右利爪小鼠长【左利爪(47.5&plusmn;8.689)s vs右利爪(26.53&plusmn;2.414)s,P&lt;0.05】,差异具有统计学意义。结论提示右利爪小鼠较左利爪小鼠更易出现焦虑样行为,但不同利爪小鼠的抑郁样行为没有差异。</p