Preparation of HCPT-loaded ultrasonic microbubbles and their enhanced antitumor effect combing with ultrasound

原发性肝癌是威胁人类健康的重要疾病之一，目前关于肝癌的治疗手段以手术切除和化疗为主，然而手术切除治愈率低且易复发；传统的化疗药物无靶向性，毒副作用较大。因此，寻找更安全有效、靶向性高、毒副作用小的治疗方法非常必要。近年来，载药超声微泡因其本身特性备受人们关注，在超声联合载药微泡治疗肿瘤方面的研究已经取得了一些研究成果。 本文结合本实验室以往的研究成果，本文以聚乳酸为载体，以10-羟基喜树碱（HCPT）为模型药物，采用正交试验设计，采用SPG膜乳化法制备出一定粒径、高载药量和包封率的缓释微泡，并通过MTT细胞毒性实验和小鼠肝癌模型的体内抑瘤实验考察所得微泡本身以及采用联合超声协同作用的抑瘤效果...Hepatocellular carcinoma (HCC) is a grave threat to human health. At present, surgical resection and chemotherapy are the main treatment methods for it. However, both of them are imperfect alternatives because of the low excision rate and high recurrence rate of surgical resection, and lack of targeting and high cytotoxicity to body of traditional chemotherapy drugs. So it is essential to explore ...学位：理学硕士院系专业：医学院药学系_药理学学号：2452009115302

Character Tables of Finte Groups of lower Orders

摘要 本文主要讨论了通过群的同构分类的观点系统给出了低阶（31阶以下）群的特征标表。为了解决这一问题，本文引用一个主要定理（文献1），通过这个定理解决了24阶群的所有同构分类情况， 构造低阶群的特征标表工作是一个专业性很强的课题，很多参考书没有具体讨论。本文具体地分析了群的结构，第二章，我们证明一些有关群同构理论和特征标的理论。第三章，我们主要探讨低阶群的同构关系。第四章，我们利用低阶群的同构关系构造其相应的特征标表。 关键词：生成关系；同构；特征标Abstract In this thesis,we study the character tables of finite groups of lower orders (less than 31 orders ). We construct the character tables by isomrophisc classifications of finite groups. We use a primary theorem (literature 1) in order to solve all isomorphic sorts the 24 orders group. Constructing the character tables of finite groups of lower orders is a professional problem . We...学位：理学硕士院系专业：数学科学学院数学与应用数学系_基础数学学号：X20042300

中医治疗痤疮的临床应用

痤疮,又称为\"粉刺\",是毛囊皮脂腺单位的一种慢性炎症性皮肤病,其发病机理不甚清楚,辨证施治复杂,临床表现以好发于人颜面部、胸背部皮肤的粉刺、丘疹、脓疱、结节,甚至疤痕等多形性皮损为特点。主要好发于青少年,青春期后往往能自然减轻或痊愈。随着社会节奏的加快、饮食或(和)睡眠的失调以及心理压力的剧增,导致痤疮患者越来越多,对患者的心理和社交影响很大,也影响年青人的爱美

Association of dietary patterns with metabolic syndrome among residents in Xiamen city

目的探讨福建省厦门市居民膳食模式与代谢综合征(MS)及其组分之间关系。方法本研究于2015年12月-2016年9月采用多阶段分层整群随机抽样的方; 法,对厦门市2; 508名≥18岁居民进行膳食调查、体格测量及生化指标检测,采用因子分析法确定膳食模式,分析不同膳食模式与MS及其组分的关系。结果因子分析结果得出; 调味品模式、沿海特色模式、奶类少油模式、水果蔬菜模式4种膳食模式;多因素logistic回归分析显示,控制混杂因素后,调味品模式是MS组分高血压; 的危险因素(最高三分位数相对于最低三分位数的比值,即T3:T1OR=1.60,95%CI=1.19~2.15),奶类少油模式是MS(T3:T1; OR=0.47,95%CI=0.30~0.75)和高血压(T3:T1; OR=0.49,95%CI=0.36~0.65)的保护因素;未发现沿海特色模式和水果蔬菜模式与MS及其组分之间存在统计学关联。结论膳食模式与MS; 及其组分血压发现水平存在一定关联,减少食用盐、食用油的摄入、增加奶类的摄入,对预防MS及其组分血压水平有重要意义。Objective To explore the relationship between dietary pattern and; metabolic syndrome (MS) in residents of Xiamen city. Methods Using; multistage stratified cluster random sampling,2 508 residents were; selected to receive a dietary survey and anthropometric and biochemical; measures from December 2015 to September 2016.Factor analysis was used; to identify food patterns based on the dietary survey.Chi-square test; and logistic regression were used to analyze the relationship between; food patterns and MS and its components. Results Four dietary patterns; were identified,including condiment,sea food,more milk and less oil,and; fruits and vegetables pattern.After adjusting for potential confounding; factors,the upper tertile (T3) of the condiment pattern was associated; with higher risks of hypertension compared with the lowest tertile; (T1)(T3:T1 odds ratio[OR]=1.60,95% confidence; interval[95%CI]=1.19-2.15).T3 of the more milk and less oil pattern was; associated with lower risks of MS and hypertension compared with the; T1(T3:T1 OR=0.47,95%CI=0.30-0.75;T3:T1 OR=0.49,95%CI=0.36-0.65).No; correlation was found between the sea food pattern,fruits and vegetables; pattern with MS and its components. Conclusion Dietary patterns are; associated with MS and blood pressure levels.Limiting intake of table; salt and oil,increasing intake of milk may play important roles in the; prevention of MS and high blood pressure

Active queue management mechanism of active network

针对主动网络这种新型网络体系能为主动队列的管理提供更加灵活和有效的方法,以及目前主动网络中主动队列的管理仍然简单移用传统网络算法这一情况,深入研究了这种简单移用存在的弊端,及应专门为主动网络设计主动队列管理机制的重要性和必要性。在此基础上,利用主动网络中路由器有着对流经其上的用户数据进行计算的特征,提出了主动网络环境下,基于资源动态协商的主动队列管理机制,并用OPNET8.0进行了仿真实验,验证了该机制在丢包率、队列长度和包延时等方面的优势。Active network represents a new approach of network architecture which can provide a more flexible and effective management mechanism for active queue. In view of this and considering that traditional algorithms of active queue management are still used in active network, the shortcoming of using traditional algorithms in active network, importance and necessity of setting up a special active queue management algorithm for active network are studied. Active network's routers can perform computations on user data, while packets can carry programs to be executed in routers and possibly change their state. With this characteristic, an active queue management mechanism, based on dynamic resource trading, is put forward A simulation that used to trove the advantages of the proposed mechanism in packet drop rate, length of queue and packet delay time is made under OPNET8.0 environment

A New Security & Safety Management Mechanism of Active Node Resources

较传统网络而言,主动网络的高复杂性引起了更加严峻的资源安全问题,特别在主动节点方面。尽管在主动网络原型系统中设计了一些安全措施,但是它们都不具通用性。这在主动网络必须和传统网络相兼容的情况下,阻碍了主动网络的发展。文中设计了主动节点资源控制核,然后深入地研究了它与传统网络安全系统的接合问题,提出了对后者的具体修改建议。Active Networks are obviously more complex than traditional networks and raise considerable security & safety (in short, we call them S&S later) problems, especially in active node. Although some S&S technologies are designed in most active networks, all of them cannot be used as a universal way. On condition that active networks must be compatible with traditional IP networks, this situation results in baffling active networks development. Based on some concepts defined in this paper, such as negative error and positive error, this paper designs a resource controlling kernel for active node. In addition, this paper comprehensively studies the problem of tying this kernel in traditional network security system, and then, puts forth some suggestions of modifying traditional network security system in two aspects of security agent lay and security service lay in detail.“十五”国防基金项目 (41 0 0 1 0 1 0 1 0 6

中国共产党对待传统文化态度与政策演变思考

实现国家富强、民族振兴、人民幸福的中国梦,建设中国特色社会主义,需要我们从中华文化传统中汲取营养,结合时代条件加以继承发扬。这其中,从哲学的角度看,特别需要处理好对待传统文化的态度与政策,以及中国传统文化、西方文化与马克思主义的关系;继承与创新发展;民族性与全球化;实践与理论相统一等一系列辩证关系

微生物吸附-化学还原法合成金钯纳米线机理研究

采用微生物吸附-化学还原法,以大肠杆菌(ECCs)为模板、十六烷基三甲基溴化铵(CTAB)为保护剂、抗坏血酸(AA)为还原剂制备金钯纳米线(Au-PdNWs),考察不同金钯摩尔比对合成金钯纳米材料的影响,并通过SEM、TEM、XRD等技术进行了表征,研究其形成机理。结果表明,吸附还原作用使ECCs在短时间内还原生成了少量Pd(0)和Au(0),大量的钯离子和金离子聚集在ECCs表面周围;还原剂AA的加入使ECCs表面成为优先成核位点,菌体表面基团与晶核相互作用阻止其迁移;在CTAB的作用下,菌体表面的纳米颗粒逐渐形成链状纳米中间结构,中间结构通过Ostwald熟化作用进一步形成Au-Pd纳米线。通过ECCs和CTAB协同作用,有利于一维纳米结构的生长。福建省教育厅中青年教科研项目(JAT171117);;莆田市工业科技类科研项目(2016G2020