チアマゾールによる顆粒球減少をきたし甲状腺全摘術を行った1 型糖尿病合併Basedow 病の1例

"　20代女性の急性発症1 型糖尿病とBasedow 病の同時期発症による多腺性自己免疫症候群（APS）3A 型を経験した．強化インスリン療法とチアマゾール（MMI）15㎎/日で治療を開始したが，顆粒球数は減少傾向となり，薬剤性顆粒球減少症と考えMMI を中止しヨウ化カリウム50㎎/日に変更したのち，甲状腺全摘術を行った． 　日本人の1 型糖尿病における自己免疫性甲状腺疾患（AITD）の合併頻度は2 ～10％であり， 1 型糖尿病とBasedow 病合併例の症例報告も多数なされている．本症例のようにMMI導入による顆粒球減少は0.2～0.5％の頻度で報告されているが，急性発症のAPS3A 型に対して外科的治療を行った症例は稀である．"journal articl

基于两端口微腔激光器空间干涉的光学生物传感器

 一种基于两端口微腔激光器空间干涉的光学生物传感器,包括：一微腔激光器,该微腔激光器为室温电注入激光器,输出的激光具有较高的边模抑制比,具有好的单模特性；一第一输出端口和第二输出端口,该第一输出端口和第二输出端口直接连接在微腔激光器上；一容器,位于微腔激光器上,该容器有一上盖；一个透明薄片,位于容器内的下部,该透明薄片与第一输出端口和第二输出端口的位置对准,该透明薄片对激光器出射光无吸收；一CCD摄像机,位于容器的上盖上,该CCD摄像机用来观测干涉条纹

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies