养正消积胶囊辅助GP方案治疗晚期非小细胞肺癌临床研究

目的观察养正消积胶囊辅助GP方案治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法采用随机数字表法将89例晚期NSCLC患者分为对照组44例及观察组45例。2组均采用GP方案;观察组并予养正消积胶囊,每次4粒,每日3次,口服。2组均21d为1个周期,连续治疗2个周期,随访1年。观察2组治疗前后Ki67、Bax、Bcl-2蛋白表达及肿瘤标志物[血管内皮生长因子(VEGF)、骨桥蛋白(OPN)、癌胚抗原(CEA)、糖类抗原199(CA199)]、中医症状评分、生活质量评分,比较2组客观缓解率(ORR)、疾病控制率(DCR)、无进展生存时间(PFS),监测不良反应。结果观察组ORR、DCR明显优于对照组(P<0.05)。与本组治疗前比较,观察组治疗后、随访1年VEGF、OPN、CEA、CA199水平明显降低(P<0.05);对照组治疗后上述指标明显降低(P<0.05),随访1年CEA水平明显降低(P<0.05)。与本组治疗前比较,2组治疗后Ki67、Bcl-2蛋白表达明显降低,Bax蛋白表达明显升高(P<0.05);2组治疗后比较,观察组Ki67、Bcl-2蛋白表达低于对照组(P<0.05),Bax蛋白表达高于对照组(P<0.05)。与本组治疗前比较,2组治疗后中医症状评分(神疲乏力、胃纳少馨、腰膝无力、夜尿频多、头晕目眩)、生活质量评分(躯体功能、认知功能、社会功能、情绪功能)明显改善(P<0.05);2组治疗后比较,观察组上述评分改善明显优于对照组(P<0.05)。观察组PFS明显长于对照组(P<0.05),不良反应明显低于对照组(P<0.05)。结论养正消积胶囊辅助GP方案治疗晚期NSCLC可有效降低患者肿瘤标志物水平,改善生存质量,减少吉西他滨和顺铂的不良反应,提高疗效。福建省卫生厅中医药科研专项课题(wst201210

From Novels to Movies, It Is not Only the Transformation ——An Experimental Study on the from Texts to Images Processing Mode of Thinking

在大学英语教学中,视听化多媒体教材利用多通道对信息进行加工,提高了课堂教学效率。但是,长期的视听化教学对语言思维和写作可能造成消极的影响。通过对深度文本阅读和观看影像两种教学方式进行实验性比较,初步发现:过度依赖影像资料可能会弱化学生对文字的想象加工;如果缺乏系统深入的语言文本学习,阅读和写作能力难以得到提升。而深度文本阅读可激发学生的批判性思维,表现为写作中的严谨规范和语言的准确性。</p

人为干扰对川西北谢家山润楠次生林群落结构和物种多样性的影响

采用典型样地法,对比研究重、中和轻3种强度人为干扰对谢家山润楠(Machilus nanmu)次生林群落结构和物种多样性的影响,采用物种丰富度指数(D)、Simpson优势度指数(H')、Shannon-Wienner多样性指数(H)和均匀度指数(JSW)来综合衡量群落的物种多样性水平。结果表明:(1)重度干扰群落各层次物种数最少。(2)不同强度人为干扰下润楠次生林的群落结构不同,轻度干扰群落中,在径级Ⅱ〔4.0 cm≤胸径(db,h

人为干扰对雅安莲花山青冈次生林群落结构和物种多样性的影响

以四川省雅安莲花山为研究区,采用典型样地法分别调查轻度、中度和重度人为干扰对青冈(Cyclobalanopsis glauca)次生林不同林分层次的物种组成、群落结构和物种多样性的影响。采用物种丰富度指数(S)、Shannon-Wiener指数(H)、Simpson优势度指数(H′)和均匀度指数(Jsw)来综合分析群落的物种多样性水平。结果表明:(1)在总面积为3 600m2的9个样地中,共记录到维管束植物161种,隶属于83科134属,以禾本科(Gramineae)、樟科(Lauraceae)、壳斗科(Fagaceae)、山茶科(Theaceae)等植物为主。(2)不同强度人为干扰下青冈次生林的群落结构不同,受轻度和中度干扰的群落乔木层处于小径级(胸径8cm以下)、低高度级(高度3~7m)的幼苗较多,林分具有潜在的天然更新能力,受重度干扰下群落乔木小径级、低高度级个体数少,群落结构不稳定,林分生产力低。(3)不同强度人为干扰下青冈次生林群落重要值差异显著,轻、中、重干扰下乔木层优势种数量差别不明显,物种组成单一;灌木层重度干扰下小果润楠(Machilus microcarpa)占据绝对优势地位;草本层优势种在中度干扰下数量最多。(4)随着人为干扰强度的增加,青冈次生林群落的S、H、H′和Jsw降低,群落物种多样性整体呈下降趋势

Electrodeposition of CIGS Thin Film with Special Structure Using Laser Etching Template

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 本文利用激光刻蚀模板，在水溶液中电沉积制备金属铜薄膜，讨论了温度、电流、硫酸铜浓度对薄膜形貌的影响. 采用SEM对制备的铜薄膜进行表征，结果表明在沉积温度为30 ℃，沉积电流为4 A&middot;dm-2(表观工作电流密度)，硫酸铜浓度在20 ~ 50 g&middot;L-1的水溶液中电沉积可以得到中空馒头状和开口碗状结构的铜薄膜. 利用激光刻蚀模板，在离子液体1-丁基-3-甲基咪唑三氟甲磺酸盐([BMI][TfO]) - 30 Vol%丙醇混合电解质中电沉积CIGS薄膜，研究了沉积电势、沉积时间对薄膜形貌的影响. SEM观察发现，在沉积电势为-1.8 V，沉积时间为1.5 h条件下电沉积可以得到近似柱状的簇状花束样的CIGS薄膜， 电沉积铜后再进一步电沉积CIGS，得到了均匀有序的鼓包柱状结构的Cu/CIGS复合薄膜. 用恒电势方波法对制备的薄膜真实表面积进行测试，计算结果表明，与无模板电沉积制备的CIGS薄膜相比，激光刻蚀模板法制备的Cu/CIGS复合薄膜的表面积提高了约8倍.Copper indium gallium selenide (Cu1.00InxGa1-xSe2.00, CIGS) thin film solar cells have a wide application in semiconductor thin film batteries. The CIGS absorbing layer is the key of the thin film solar cell material. Therefore, it is of theoretical and practical significance to carry out researches in CIGS thin films. In this work, the CIGS thin films with special structures were prepared by using laser etching template. The copper thin film was firstly electrodeposited in aqueous solution with Laser etching template. The influences of temperature, current and concentration of copper sulfate on morphology and structure of the thin film were studied. The results showed that a hollow steamed bun shape and open bowl structure was formed at the surface of copper thin film electrodeposited at 30 oC and at the apparent current density of 4 A&middot;dm-2 in the aqueous solution with the concentrations of CuSO4&middot;5H2O being 20 ~ 50 g&middot;L-1. The CIGS thin films were electrodeposited by using laser etching template in the ionic liquid 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([BMIm][TfO]) - 30 Vol% propyl alcohol mixed electrolyte solution at different deposition potentials, substrates and deposition time. It was demonstrated that the clusters of flowers with approximate columnar CIGS thin film could be prepared at 1.8 V for 1.5 h. Furthermore, the electrodeposition of CIGS thin films was done on the previously electrodeposited copper substrate by Laser etching template. A uniform and orderly spheroidal structure of Cu/CIGS composite film was obtained. The apparent surface area of the Cu/CIGS composite film, calculated by constant voltage square wave method, was about 8 times larger than that of the CIGS thin film prepared without using template, which greatly enhanced absorption of light on the thin film and increased the output of the carrier. Therefore, it can be expected that the CIGS thin film with globular special structure electrodeposited in ionic liquid by laser etching template may highlight the electric conversion efficiency.国家自然科学基金项目（51474080）资助作者联系地址：哈尔滨工业大学化工与化学学院，黑龙江哈尔滨 150001Author's Address: School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, Heilongjiang, China通讯作者E-mail：mzan@hit. edu. c

The Interaction of Ternary Components of Ionic Liquid Gel Polymer Electrolytes for Lithium Metal Batteries

采用Raman光谱、傅里叶转换红外光谱和X-射线衍射光谱研究N-甲基-N-丙基哌啶双三氟甲磺酸亚胺离子液体（PP13TFSI）和双三氟甲磺酸亚胺锂盐（LiTFSI）对PVDF-HFP聚合物聚合方式的影响,结果表明,PP13TFSI、LiTFSI和PVDF-HFP是共混存在的,同时加入PP13TFSI和LiTFSI会使聚合物的聚合方式由晶体结构转变为无定形结构. 通过对电解质及其各组分的线性扫描伏安曲线和热重曲线分析可知,溶剂N-甲基吡咯烷酮（NMP）容易残留在凝胶聚合物电解质（ILGPE）中,这会降低ILGPE的电化学稳定性和热稳定性. 作者对固态LiFePO4|ILGPE|Li电池的倍率性能进行了研究,实验结果表明其具有较好的倍率性能,当电池倍率由C/10增大至2C,然后再回到C/10时,其容量可以恢复到原来的90.9%左右. 该研究结果对理解PP13TFSI和LiTFSI在ILGPE中的作用机理具有重要的意义.Ionically conductive gel polymer electrolyte is an excellent candidate due to its inflammable, nonvolatile and high thermal stability as compared to commercial liquid electrolytes which are usually flammable, volatile, and containing toxic organic solution as solvent, The synthesis and application of ionic gel polymer electrolytes in lithium ion/metal batteries have been previously reported. However, the interaction effects of N-methyl-N-propylpiperidinium bis(trifluoromethanesulfonyl)imide (PP13TFSI) ionic liquid (as plasticizer) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) on PVDF-HFP polymer remain unclear. In this work, the molecular structure of ionic liquid gel polymer electrolyte (ILGPE) composed of PP13TFSI, LiTFSI and PVDF-HFP was studied by Raman spectroscopy and Fourier-transform infrared spectroscopy (FTIR). Meanwhile, X-ray diffraction (XRD) analysis was performed to qualify the crystallization of PVDF-HFP polymer in the ILGPE with or without PP13TFSI or/and LiTFSI to investigate ionic liquid or/and LiTFSI impact on PVDF-HFP polymer. The results showed that PP13TFSI, LiTFSI and PVDF-HFP were physical-blending without chemical reaction, but with molecular coordination with PVDF-HFP polymer chain. In addition, the crystallization of PVDF-HFP could be changed by additions of PP13TFSI and LiTFSI at the same time, and the ionic conductivity could be improved with increasing amorphous phase in polymer matrix. The electrochemical stability window and thermal stability of ILGPE became worse with the N-methyl-2-pyrrolidone (NMP) residue inside the ILGPE. The LiFePO4/Li battery with the optimized ILGPE (the weight ratio of ionic liquid, LiTFSI, and PVDF-HFP polymer was 3/1/1) showed a good C-rate capability at room temperature. In summary, PP13TFSI and LiTFSI could coordinate with PVDF-HFP polymer chain, and no chemical reaction took place among the three compounds during preparing ILGPE. Furthermore, it is necessary to remove NMP solvent from ILGPE during drying process to improve the electrochemical stability window and thermal stability of ILGPE.国家自然基金项目（No.21878061）和国家自然科学基金项目（No.51604102）资助通讯作者:杨培霞E-mail:[email protected]:YANGPei-xiaE-mail:[email protected]. 哈尔滨工业大学化工与化学学院,黑龙江 哈尔滨 1500012. 黑龙江科技大学 环境与化工学院,黑龙江省 哈尔滨 1500011. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001,Heilongjiang 2. School of Environment and Chemical Engineering, Heilongjiang University of Science and Technology, Harbin 150001, Heilongjian