Hospitalization Expenses of Breast Cancer with Different Payments Based on Gamma Model

目的分析不同支付方式的女性乳腺癌患者住院费用,为合理控制乳腺癌住院费用提供依据。方法收集厦门市某三甲医院2004-2012年入院接受治疗且信息完整的女性乳腺癌患者的人口学、疾病、治疗和住院费用资料,采用Gamma模型分析医保与非医保患者的各项住院费用的差异,并估计边际均值及其95%可信区间。结果共纳入451例乳腺癌住院患者,其中医保患者占71.2%;医保与非医保患者中位住院费用分别为12696.4元和11216.5元,其中药品费分别占40.0%和38.8%,检查费分别占23.2%和22.5%,床位费分别占4.5%和4.3%。在控制协变量的影响后,医保和非医保患者的总住院费用(8889.5元vs 6807.6元)、药品费(1721.2元vs 1290.9元)、检查费(3366.5元vs 2400.6元)和床位费(488.9元vs 299.6元)差异均有统计学意义,医保患者的总住院费用、药品费、检查费和床位费分别是非医保患者的1.31、1.33、1.40和1.63倍。结论基于Gamma模型分析支付方式对乳腺癌住院费用的影响具有一定的科学合理性。医疗支付方式在一定程度上影响女性乳腺癌患者的住院费用,医保患者住院费用高于非医保患者,药品费、检查费和床位费是主要的差异来源。Objective To study the difference of hospitalization expenses between insured and uninsured female breast cancer patients with Gamma model. Methods The female patients with breast cancer in a tertiary hospital in Xiamen from Jan1,2004 to Dec 31,2012 were recruited into our study,whose demographics,disease situation,treatment and hospitalization expenses were collected. Gamma model was applied to analyze hospitalization expenses for insured and uninsured patients under control of other covariates,and to estimate marginal means. Results The study included 451 patients with 71. 2% of which were insured. For insured and uninsured patients,the median cost of hospitalization was 12696. 4 RMB and 11216. 5 RMB,respectively. The proportions of the compositions of hospitalization cost were 40. 0% and 38. 8% for drug cost,23. 2% and 22. 5% for examination cost,4. 5% and 4. 3% for bed cost,respectively. After controlling other covariates,total hospitalization cost(8889. 5 RMB vs. 8889. 5 RM B),drug cost( 1721. 2 RMB vs. 1721. 2 RMB),examination cost( 3366. 5 RMB vs. 3366. 5RMB),and bed cost(488. 9 RMB vs. 488. 9 RMB) between insured and uninsured patients were significantly different. Total cost,drug cost,examination cost and bed cost of insured patients were higher than uninsured patients with 0. 31,0. 33,0. 40,and0. 63 times respectively. Conclusion For its advantage in deal with skewed data,the Gamma model has its own rationality and validity on analysis of hospitalization expense. The hospitalization expense of female breast cancer patients with medical insurance was higher than uninsured patients. Drug cost,examination cost and bed cost made a main contribution of difference.国家自然基金青年项目(71403229);; 厦门市科技计划项目(3502Z20143006

Analysis on 6 Cases of Adverse Drug Reactions Induced by Ammonium Chloride and Licoricl Oral Solution

目的：探讨氯化铵甘草口服溶液不良反应的特点,为临床安全用药提供参考。方法：对本院2014年1月-2016年3月上报的6例氯化铵甘草口服溶液不良反应监测报告进行回顾性分析,对6例患者的年龄、性别、原患疾病,药物使用情况,ADR发生时间、临床表现、治疗与转归,ADR的类型与关联性评价等项目进行统计分析。结果：氯化铵甘草口服溶液不良反应多发生于老年患者;发生时间主要在用药8h内;以累及系统呼吸系统和皮肤为主;6例患者均痊愈,未出现后遗症或导致死亡。6例ADR中一般的ADR 2例,新的一般的ADR 2例,新的严重ADR 2例;关联性评价为可能4例,很可能2例。结论：临床上应重视氯化铵甘草口服溶液的不良反应,应密切观察患者,保证用药安全。Objective： To explore the characteristics of the adverse drug reactions （ADRs） induced by ammonium chloride and licoricl oral solution, to provide the reference for clinical safe medication and prevent adverse reaction. Methods：Restrospectively analysis were used on the ADRs reports of 6 cases of ammonium chloride and licoricl oral solution form January 2014 to March 2016 in our hospital. The application of drug, the age and gender distribution of patients ,occurrence time of ADRs, clinical manifestations ; treatment and outcome ; types and relevance evaluation of ADRs were analyzed respectively. Results：ADRs were mostly happened in the senile patients 8h after the medication. The clinical manifestations were respiratory and skins. 6 patients were all recovered, no occurrence sequel or lead to death. There were 4 cases of new ADR ,4 cases of commom ADR and 2 cases of severe ADR, 4 cases of possible relevance and 2 cases of probale relevance. Conclusion：The ADRs caused by ammonium chloride and licoricl oral solution should be pay more attention to, observed the changes closely to ensure clinical safe mediation

通过发表OA论文来提高学术影响力

1、生物物理所OA论文发表及学术影响力分析；2、与科研相关的OA；3、如何发表OA论文；4、开放科技资源介

经济全球化与中国文学

中国文学面临的冲击林兴宅:我们回顾20世纪90年代以来,中国的文学受到三次冲击。第一次是市场化或者叫商品化的冲击,最明显的变化就是文学边缘化,整个中心转移了,企业家充当了社会主流角色,文学退到社会的边缘再一个变化就是文学和商品的实现连在一起,精品文学慢慢失去社会的关注,而一些流行的、时尚的文学作品地位却在上升。第二次冲击是网

数字微流控技术及其在生物分析中的应用

数字微流控技术是一种基于微电极阵列来实现离散液滴精确控制的新型液滴操纵技术。这种基于介电润湿现象实现的液滴电操纵体系,相比于传统微流控芯片具有自动化、可寻址、可动态配置、易集成等特点。该文介绍了数字微流控技术液滴驱动原理,总结了芯片的结构和常用的制作方法,举例阐述了现阶段该技术在生物分析化学领域的应用,并对其应用前景做了展望。国家自然科学基金资助项目(21735004,21435004,21775128,21705024,21521004);;长江学者和创新研究团队项目(IRT13036

十一种壳聚糖衍生物的紫外吸收特性

通过对O-氰乙基壳聚糖、N-苄基壳聚糖等11种壳聚糖衍生物的紫外吸收特性的研究发现,在稀溶液体系中,这些衍生物的紫外吸收光谱都可以覆盖整个UV-B区(280~320 nm),其中N-羟基苄基壳聚糖、N-苯基乙烯基甲基壳聚糖甚至可以覆盖至UV-A区(>320 nm);大部分衍生物吸收强度可达中等以上,N-苯甲醛西佛碱壳聚糖、N-羟基苄基壳聚糖、N-苯基乙烯基甲基壳聚糖、辛基氨基甲酸酯基壳聚糖、萘基氨基甲酸酯基壳聚糖达到强吸收。而在浓溶液体系中,虽然由于浓度过高不能得到完整的谱图,但是可以通过其出峰位置的移动来说明其聚集态的变化。液晶临界浓度附近,峰的位置移动较大,而将液晶态冻结下来的N-苄基壳聚糖薄膜的紫外光谱已经可以覆盖大部分的UV-A区

Hypoglycemic action of acidic polysaccharide in leaf of Gynura divaricata and its effect on related indexes

与西药相比,传统中药及其提取物具有经济、安全的优点,同时还可避免西药的许多副作用[1]。中药材白子草又名白背三七,为菊科(COMPOSITAE)三七属(gynurA CASS.)植物白子菜〔gynurA dIVArICATA(lInn.)dC.〕的干燥叶,具有清热、舒筋、止血、祛痰等功效[2]。在民间,白子菜的茎和叶可药食两用,用于治疗高血压、糖尿病和高血脂症等[3],其化学成分复杂,目前已分离获得多糖类[3]、黄酮类[4-6]、生物碱[4,7-8]和脂肪酸[9]等成分。Gynura divaricata acidic polysaccharide( GDAP) was extracted and purified from dry leaf of Gynura divaricata( Linn.) DC.Effects of successive lavage GDAP for 0,7,14 and 21 d with daily dose of 15,37 and 60 mg·kg- 1on blood glucose content of diabetic model mice were analyzed,and differences in SOD activity and MDA content in serum and glycogen content in liver of mice were compared.The results show that with prolonging of successive administration time and increasing of GDAP daily dose,blood glucose content of diabetic model mice generally appears the decreasing trend.With successive administration for 14 and 21 d,blood glucose content of different GDAP treatment groups is generally lower than that of CK group( 0.9% Na Cl injection with daily dose of 10 m L·kg- 1) but higher than that of T1group( metformin with daily dose of 200 mg·kg- 1).In which,after successive administration GDAP for 21 d with daily dose of 37 and60 mg·kg- 1,blood glucose content of diabetic model mice is significantly or extremely significantly lower than that of CK group but significantly or extremely significantly higher than that of T1 group,while SOD activity in serum of diabetic model mice is significantly higher and its MDA content is significantly lower than those of CK group,but there is no significant difference with those of T1 group.Glycogen content in liver of diabetic model mice of different GDAP treatment groups is higher than that of CK group,but lower than that of T1 group.It is suggested that GDAP is the main hypoglycemic components in polysaccharide of G.divaricata leaf, and it has dose-effect relationship in hypoglycemic activity.Hypoglycemic mechanism of GDAP is probably related to improving antioxidant enzyme ability in the body,enhancing activity of scavenging oxygen free radicals,relieving liver damage,and increasing glycogen storage capacity.福建省自然科学基金资助项目(2012J01400

催化裂解法制备碳纳米管中试反应器优化研究

对催化裂解法(CVD)间歇制备多壁碳纳米管(CNTs)的中试流化床反应器的结构进行优化研究,以期简化结构、改变出料方式、实现半连续化操作。实验结果表明:床层内置加热器开启,CNTs产量下降15%,床层阻力增加67%;预热层高度为零,反应4h,产率最高为9.2g/g;催化剂量为100g,最佳匣钵高度是35cm;将间歇操作调整为半连续操作,生产周期将从24.0h降为8.5h

Direct conversion of methane to formaldehyde and CO on B2O3 catalysts

甲烷作为天然气的主要成分，是非常重要的碳基资源。不过，甲烷分子的化学惰性使得其转化通常需要在高温条件下进行，反应选择性难于控制。如何实现甲烷的高选择性定向转化一直是化学研究中的重要挑战，甚至被誉为化学领域的“圣杯”。化学化工学院王帅教授与华盛顿州立大学王勇教授合作在甲烷选择氧化反应非金属硼基催化剂的研究中取得重要进展，本研究中发现负载型氧化硼催化剂在甲烷直接氧化反应中表现出优异的抗深度氧化能力。本研究工作是在王帅教授和王勇教授的共同指导下完成。2015级博士生田金树（已毕业）、硕士生谈江乔（已毕业）以及醇醚酯清洁生产国家工程实验室张朝霞工程师为共同第一作者，林敬东副教授和万绍隆副教授等参与了部分研究和讨论。【Abstract】Direct oxidation of methane to value-added C1 chemicals (e.g. HCHO and CO) provides a promising way to utilize natural gas sources under relatively mild conditions. Such conversions remain, however, a key selectivity challenge, resulting from the facile formation of undesired fully-oxidized CO2. Here we show that B2O3-based catalysts are selective in the direct conversion of methane to HCHO and CO (~94% selectivity with a HCHO/CO ratio of ~1 at 6% conversion) and highly stable (over 100 hour time-on-stream operation) conducted in a fixed-bed reactor (550 °C, 100 kPa, space velocity 4650 mL gcat−1 h−1 ). Combined catalyst characterization, kinetic studies, and isotopic labeling experiments unveil that molecular O2 bonded to tri-coordinated BO3 centers on B2O3 surfaces acts as a judicious oxidant for methane activation with mitigated CO2 formation, even at high O2/CH4 ratios of the feed. These findings shed light on the great potential of designing innovative catalytic processes for the direct conversion of alkanes to fuels/chemicals.This work was supported by the National Natural Science Foundation of China (No. 21922201, 21872113, 91945301, 21673189, and 91545114) and the Fundamental Research Funds for the Central Universities (No. 20720190036 and 20720160032).研究工作得到了国家自然科学基金（21922201、21872113、91945301、21673189、91545114）和中央高校基本科研业务费专项资金（20720190036、20720160032）的资助与支持

CCCCC pentadentate chelates with planar Möbius aromaticity and unique properties

本课题充分发挥了厦门大学多学科协同研究优势，通讯作者为夏海平教授（合成、表征）、刘刚教授（生物医学应用）和吕鑫教授（理论计算）。合成实验和结构表征由朱从青（第一作者，目前在麻省理工学院、2005年诺贝尔化学奖得主Richard Schrock教授课题组从事博士后研究）完成；生物医学应用由杨彩霞（共同第一作者）、林凎、杨宇惠、王晓勇合作完成；理论计算由朱军、王永恒、朱从青完成。美国NIH的陈小元教授参与了生物医学应用的讨论。该研究工作得到国家自然科学基金委、科技部项目的支持。The coordinating atoms in polydentate chelates are primarily heteroatoms. We present the first examples of pentadentate chelates with all binding atoms of the chelating agent being carbon atoms, denoted as CCCCC chelates. Having up to five metal-carbon bonds in the equatorial plane has not been previously observed in transition metal chemistry. Density functional theory calculations showed that the planar metallacycle has extended Craig-Möbius aromaticity arising from 12-center–12-electron dπ-pπ π-conjugation. These planar chelates have broad absorption in the ultraviolet-visible–near-infrared region and, thus, notable photothermal performance upon irradiation by an 808-nm laser, indicating that these chelates have potential applications in photothermal therapy. The combination of facile synthesis, high stability, and broad absorption of these complexes could make the polydentate carbon chain a novel building block in coordination chemistry.the National Basic Research Program of China (nos. 2012CB821600 and 2014CB744503) , the National Science Foundation of China (nos. 21332002, 81422023, 51273165, 21490573, and 21573179)