永久起搏器患者中QRS宽度与心房颤动的关系

【目的】探讨永久性起搏器患者的起搏QRS 波宽度（QRSd）与术后心房颤动（AF）发生的关系。 【方法】我们回顾收集了180例因完全性/进展性房室传导阻滞而行永久性起搏器植入术的患者。所有的患者都 是右室间隔部起搏。心电图在术前和术后都有记录。QRSd在部分胸前导联（V1，V4和V6）、I导联和AVF导联 都有测量，QRS波差值由术后起搏QRSd减去术前QRSd获得。【结果】AF发生在64（35.56%）例患者中。AF发生 组和没有AF 发生组间，术前的QRSd 相比没有统计学差异，但QRSd 差值在V4 导联（P=0.022）和V6 导联 （P=0.001）有统计学差异。COX比例风险模型提示V6导联的QRSd差值（P=0.005，HR 1.822，95%CI 1.174-2.718， QRSd的间隔区值定为40 ms）和左心房直径（P=0.045，HR 1.042，95%CI 1.001-1.086）是预测AF发生的独立危 险因素。ROC曲线提示V6导联的QRSd差值可以预测AF的发生，尤其是术前QRSd较长的患者（≥120 ms，曲线 下面积为0.826，95%CI 0.685-0.967）。【结论】V6导联的QRSd差值与术后AF的发生可能存在正相关关系

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies