MR Immunoimaging Using Antihuman Lung Cancer Monoclonal Antibodies Labelled Gadolinium

目的：探讨gd标记抗肺癌单抚对荷瘤裸鼠的定向增强效应。材料与方法：用dTPA环二酸研与抗肺癌单抗3d3和gd3--3+分别偶联，制备出gd-dTPA-Igg：建立6只荷瘤裸鼠模型；将gd-dTPA-Igg按2Mg单抗/只的剂量从尾静脉内注入；观察平扫及注药后6小时瘤体磁共振信号。结果：gd-dTPA-Igg能选择性增加瘤灶的信号强度。结论：磁共振免疫成像为肺癌定性提供一种潜在新的方法。Purpose: To explore the Possibilitv of specific contrast enhancemen1 in nude mice hosted lung cancer using Gd labelled monocloa1 antibodies against lung adenocarcinorna.Materials and Methods: Uslng cyclic anhydride DTPA as a bifunctional chelat1ng a- gent, Gd3+ was attached to a monoclnal antihody (3D3).6 nude mlce carrying the 1ung cancer were esta[)lished.Then, Gd - DTPA - IgG was intravenously injected at a dose of 2mg IgG/mouse.MR scans wcre performed before and 6 hours after administration of Gd - DTPA - IgG.ResultS: all tumor of nodules were specifically cnhancecl with Gd - DTPA - IgG.ConcIusion: MR immunoimaging is a promise method for detecting lung cancer

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies