The protective effect of letrozole in a rat ovarian ischemia-reperfusion injury model

INTRODUCTION: Torsion of the ovary is a surgical emergency. Future fertility is an important question for choosing the most appropriate treatment strategy as radical or conservative. Conservative treatment includes detorsion of the twisted ovary and after detorsion, the ischemic injury in ovary increases with reperfusion. During the detorsion process, abundant amounts of reactive oxygen species (ROS) are produced. ROS causes cellular injury by attacking cellular membranes through the peroxidation of polyunsaturated fatty acids and causing cellular death. Letrozole is a nonsteroid aromatase inhibitor that blocks estrogen production in all tissues, increases gonadotropin secretion and induces follicular development. METHODS: In this study, rats are divided into 5 groups including 8 rats in each group; control group, ischemia group, ischemia and letrozole group, ischemia-reperfusion group, ischemia-reperfusion and letrozole group. For each group Malondialdehyde (MDA) levels were measured, degree of ischemia and number of follicles were recorded by histopathological examination. Endometrial thicknesses were also measured. RESULTS: In the ischemia and ischemia-reperfusion groups, MDA levels and grade of ischemia were significantly decreased with letrozole. Ovarian follicle numbers were higher and endometrial thickness was lower in the letrozole used groups. DISCUSSION AND CONCLUSION: Letrozole can be protective on ovarian ischemia-reperfusion injury and this effect will be related to hypoestrogenic environment by inhibition of aromatase activity, antiinflammatory effects and increased blood flow to the ovary by letrozole

Bir Türk alt popülasyonunda kalıcı üst azı dişlerinin kök kanal konfigürasyonunun değerlendirilmesi: Konik ışınlı bilgisayarlı tomografi çalışması

Objective: Maxillary molars may be challenging for root canal treatment due to their complex canal anatomy and additional root canals, especially in the mesiobuccal root. The current study aimed to investigate the prevalence of root and root canal numbers of maxillary molar in a selected Turkish population. Materials and Methods: A total of 905 first and second maxillary molars were evaluated using cone-beam computed tomography (CBCT) images. The number of roots and canals was recorded and the mesiobuccal canal was further evaluated with the Vertucci classification. Results: A total of 394 teeth had a second mesiobuccal (MB2) canal (43.5%). While 90.4% of all maxillary molars had three roots, 44% had four root canals. The most common root canal anatomy of mesiobuccal root canals was Type II (42.6%) followed by Type IV (31.5%) and Type III (22.1%). Conclusions: It is clear that the second mesial root canal in permanent maxillary molars should be carefully searched for the long-term success of root canal treatments. It is seen that CBCT sections will be beneficial in diagnosis and treatment in better understanding the anatomical structure of the teeth and determining possible anatomical deviations.Amaç: Üst çene azı dişleri, karmaşık kök kanal anatomisi ve özellikle mezial kökteki ek kök kanal sayıları nedeniyle endodontik tedaviyi zorlaştırabilir. Bu nedenle başarılı bir kanal tedavisi için üst çene azı dişlerinin anatomik özelliklerinin analiz edilmesi gerekmektedir. Bu çalışmanın amacı, seçilmiş bir Türk nüfusunda üst çene azı dişlerinin kök ve kök kanal sayılarının prevalansını araştırmaktır. Materyal ve Metot: Konik ışınlı bilgisayarlı tomografi (KIBT) kullanılarak toplam 905 birinci ve ikinci kalıcı üst azı dişi değerlendirildi. Kök ve kök kanal sayıları kaydedilerek mezyobukkal meziobukkal kök kanalı Vertucci sınıflamasına göre değerlendirildi. Bulgular: Toplam 394 üst azıda ikinci bir mezial (MB2) kök kanalı (% 43,5) vardı. Tüm üst büyük azı dişlerinin %90,4' ünde üç adet kök varken, %44'ünde ise 4 kök kanalı vardı. Mezial kök kanallarının en yaygın kök kanal anatomisi Tip II (% 42,6) iken, bunu Tip IV (% 31,5) ve Tip III (% 22,1) takip etti. Sonuç: Üst daimi azı dişlerindeki ikinci mezial kök kanalının, kanal tedavilerinin uzun dönem başarısı için dikkatlice aranmasında büyük fayda olduğu açıktır. Dişlerinin anatomik yapısının daha iyi anlaşılmasında ve olası anatomik sapmaların belirlenmesinde KIBT kesitlerinin teşhis ve tedaviye oldukça yardımcı olacağı görülmektedir

Ağır petrol-linyit / bitümlü şist karışımlarının yanma etkilerinin belirlenmesi ve alternatif enerji kaynağı olarak kullanabilirliğinin araştırılması

TÜBİTAK TBAG Proje01.05.201

Working Across Time Zones in Cross-Cultural Student Teams

The ability to collaborate with fellow workers from different cultures on international projects is a key asset in today's job market. International projects add new dimensions to student teamwork. These types of projects give students the opportunity to participate in collaboration that is remote, cross-cultural, and linguistically challenging. This proposal examines an international term project completed by the computing students of Rose-Hulman Institute of Technology and Bilkent University

Use of Intuitive Tools to Enhance Student Learning and User Experience

Most user interfaces today present system functions by use of verbal or iconic symbols on static 2D menu pages organized in a hierarchical system. This is unnatural to all human beings and must be learned, thus being a barrier between the full use and understanding of computer systems. With this problem in mind we set out to build a website and collaborative application for International Children's Center (ICC) which could be used not only across languages but across ages as well. This effort was tested on a daily basis by a multinational team consisting of students from the United States and Turkey as well as children from the respective countries. This attention to usability will not only lead to an intuitive tool for the client but also teach the students in the course how to build intuitive user interfaces

The Investigation of Antidiabetic Effects of Leontice leontopetalum Extract on Human Pancreatic β Cell Lines (1.1B4) Treated with Streptozotocin

One of the alternative therapeutic methods is herbal medicine. Leontice leontopetalum belongs to Berberidaceae family. The aim of study was investigated the extract of LL on human pancreatic beta cell-treated with STZ. Materials and methods: The human pancreatic beta cell (1.1B4) line was used the current study. LL’s extracts (1, 10, 100, and 1000 ug/ml) were supplemented in media for twenty-four hours and/or after STZ treatment (10 and 20 mM). Cells survivals (MTT), cells proliferation were shown by using xCelligence. Insulin content and releasing were measured at 1.1, 8.4 and 16.7 mM glucose concentrations. Results: The result of MTT was shown that cell survival was decreased, based on dose-dependent. When looked at xCelligence results, cell proliferation in STZ groups and the lowest and highest concentrations of LL were attenuated in a dose-dependent manner. Also, cotreatments of LL and STZ were decreased as well. The result of insulin-releasing on glucose induction was shown that STZ concentration gave rise to reduce insulin content at low and high glucose levels. Also, co-treatment of LL and STZ attenuated insulin content based on dose. Conclusion: It was considered that LL treatment led to increased insulin realizing, resulting from decreasing insulin content in diabetic beta cells, but decrease cell survival

In a real-life setting, direct-acting antivirals to people who inject drugs with chronic hepatitis c in Turkey

Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization’s objective of eliminating viral hepatitis

Dünyada Göçmenlerin Eğitim Alanındaki Sorununa İlişkin Yasal Düzenlemeler

Göç, gelişmiş toplumlara olumlu veya olumsuz etkileri olabilen nüfusların yer değiştirme hareketi olarak tanımlanabilir. Bu nüfus hareketliliğinin çeşitleri ve etkileri değişiklik göstermektedir. Bu değişiklikler ülkelere göre de çeşitlilik gösterebilmektedir. Bu değişiklikler, beraberindeki sorunların çözümlerini ve göçün topluma olan etkilerini ortaya çıkarması açısından önemlidir. Göç alan ülkelerin genel durumlarına bakıldığı zaman ülkelerin kendilerine ait bir göçmen politikası uygulaması, göçmenleri eğitme politikası ve kendi hukuk düzenlerinde düzenlemeler yapılması zorunluluk olarak karşımıza çıkmaktadır. Göçmenlerin sorun olmaktan çıkarılıp onların topluma uyumunun sağlanması, göçmen eğitimindeki temel yolların başında gelmektedir. Eğitim alan insanların, toplumsal kurallara uymaları ve sosyolojik olarak topluma kendilerini adapte etmeleri daha kolaylaşır. Göç insanların ister kendi ülkeleri içerisinde isterse dış ülkelere yapılsın amaç kendi yaşadıkları bölgenin kötü koşullarından kurtularak daha iyi koşullar elde etmek içindir. Göçmenler çoğu zaman karma sebeplerle göç etmiş, insanların yer değiştirmelerine sebep olan durumlar, yaşanılan yer ve zamana göre değişiklik göstermiştir. Ekonomik rahatlık arayışı, çatışma ya da şiddetten uzaklaşma, politik düzensizlikler, siyasi sığınma isteği, mevcut durumlarına göre şartları daha uygun eğitim imkânları gibi çok farklı etkenden sebebiyle kişisel veya toplu göç hareketleri oluşmuştur ve oluşacaktır. Günümüzde ırkçılık kurumsal alanlarda gözle görülmez ancak derinden hissedilir olduğu bir zamana ırkçılığın artık abartılı ve saldırgan bir şekilde kendini gösterdiği zamandan doğru değişmiştir. Oluşabilecek tepkilerden çekinilmesi sebebiyle kurumsal birçok alanda ırkçılığın devam etmesinin önüne geçilmesiyle birlikte hala bu tutumun zihinlerde yer ettiği görülmektedir. Bundan dolayı hem bireysel hem de toplumsal anlamda sivil toplum örgütlerinin rolü bu alanda daha çok hissedilmektedir Dünyadaki göçmen sorununu çözmek için ülkeler, eğitim alanına ait kendi kanunlarında yeni yasal değişiklikler ve düzenlemeler yapmaktadır. Bu yasal düzenlemeler ülke içerisinde dahi değişiklikler göstermektedir. Günümüz dünyasında göç sorununa yönelik “çok kültürlülük anlayışı“ doğrultusunda uygulamalar yapılmaktadır. Çok kültürlülük çalışmaları toplumsal algının değişmesini ve kültürel çeşitliliği sağlamaktadır. Bunun için yapılan eğitim faaliyetleri, ülkelerin ve toplumların da eğitimiyle mümkün olmaktadır. Göçmen sorunlarının çözümüne yönelik daha gelenekçi anlayışlarda ise eğitimi “asimilasyon yoluyla“ yapılan politikalar çözüm yolu gibi görünse de eğitimin hedeflenen olumlu sonuçlarından ziyade olumsuz sonuçlara yol açtığı görülmektedir

First-line treatment of patients with HER2-positive metastatic gastric and gastroesophageal junction cancer

Fluoropyrimidine+cisplatin/oxaliplatin+trastuzumab therapy is recommended for the first-line treatment of HER2-positive metastatic gastric adenocarcinoma. However, there is no comprehensive study on which platinum-based treatment should be preferred. This study aimed to compare the treatment response and survival characteristics of patients with HER2-positive metastatic gastric or gastroesophageal junction (GEJ) cancer who received fluorouracil, oxaliplatin, and leucovorin (mFOLFOX)+trastuzumab or cisplatin and fluorouracil (CF)+trastuzumab as first-line therapy. It was a multicenter, retrospective study of the Turkish Oncology Group, which included 243 patients from 21 oncology centers. There were 113 patients in the mFOLFOX+trastuzumab arm and 130 patients in the CF+trastuzumab arm. The median age was 62 years in the mFOLFOX+trastuzumab arm and 61 years in the CF+trastuzumab arm (P = 0.495). 81.4% of patients in the mFOLFOX+trastuzumab arm and 83.1% in the CF+trastuzumab arm had gastric tumor localization (P = 0.735). The median progression-free survival (PFS) was significantly higher in the mFOLFOX+trastuzumab arm (9.4 months vs. 7.3 months, P = 0.024). The median overall survival (OS) was similar in both groups (18.4 months vs. 15.1 months, P = 0.640). Maintenance trastuzumab was continued after chemotherapy in 101 patients. In this subgroup, the median OS was 23.3 months and the median PFS was 13.3 months. In conclusion, mFOLFOX+trastuzumab is similar to CF+trastuzumab in terms of the median OS, but it is more effective in terms of the median PFS in the first-line treatment of HER2-positive metastatic gastric and GEJ cancer. The choice of treatment should be made by considering the prominent toxicity findings of the chemotherapy regimens