19. ve 20. yüzyıllarda Osmanlı Devleti'nin ve Cumhuriyet'in ilk yıllarında Türkiye'nin kostüm tarihi : Osmanlı Devleti dağılma dönemi ve Cumhuriyet'in ilanının etkisiyle yaşanan sosyal ve siyasi değişimlerin kıyafete etkisi

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2012.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Nesrin Ersoy McMeekin.McMeekin, Nesrin Ersoy. HIST 200-10MCMEEKIN HIST 200-10/9 2011-1

Effects of tenoxicam in experimental corrosive esophagitis model

WOS: 000352501600009PubMed: 24602009Esophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Canakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use

Experimental and computational investigation of graphene/SAMs/n-Si Schottky diodes

We have investigated the effect of two different self-assembled monolayers (SAMs) on electrical characteristics of bilayer graphene (BLG)/n-Si Schottky diodes. Novel 4″bis(diphenylamino)-1, 1′:3″-terphenyl-5′ carboxylic acids (TPA) and 4,4-di-9H-carbazol-9-yl-1,1′:3′1′-terphenyl-5′ carboxylic acid (CAR) aromatic SAMs have been used to modify n-Si surfaces. Cyclic voltammetry (CV) and Kelvin probe force microscopy (KPFM) results have been evaluated to verify the modification of n-Si surface. The current–voltage (I–V) characteristics of bare and SAMs modified devices show rectification behaviour verifying a Schottky junction at the interface. The ideality factors (n) from ln(I)–V dependences were determined as 2.13, 1.96 and 2.07 for BLG/n-Si, BLG/TPA/n-Si and BLG/CAR/n-Si Schottky diodes, respectively. In addition, Schottky barrier height (SBH) and series resistance (R s ) of SAMs modified diodes were decreased compared to bare diode due to the formation of a compatible interface between graphene and Si as well as π–π interaction between aromatic SAMs and graphene. The CAR-based device exhibits better diode characteristic compared to the TPA-based device. Computational simulations show that the BLG/CAR system exhibits smaller energy-level-differences than the BLG/TPA, which supports the experimental findings of a lower Schottky barrier and series resistance in BLG/CAR diode.The Scientific and Technical Research Council of Turkey (112T946

Larinks kanserinde prognostik bir belirteç olarak C-reaktif protein albümin oranı

During the past decade, several inflammation-based prognostic systems have been reported in the field of clinical oncology. Recently, C-reactive protein and albumin ratio (CAR) have showed their impact on a large variety of tumor types. The aim of this study is to evaluate the impact CAR on prognosis and 5-year survival (5yS) in patients operated for larynx cancer. Method: One hundred eighteen patients operated in our center between 2010 and 2015 were eligible for retrospective analysis. We evaluated the impact of the CAR and neutrophil to lymphocyte ratio (NLR) on the 5yS. Univariate and multivariate Cox regression analyses were performed to determine the associations of CAR. Results: The optimal cut-off level of CAR was at 0.993. A low and high CAR was assigned to 40.7% and 59.3% of patients, respectively. The 5yS rates of patients with a high CAR were worse than those in the low group (79.2% vs 73.2% p<0.05). Disease stage (p<0.001) and high level of NLR were also significant predictors of 5yS. CAR at diagnosis was associated with an unfavorable progress. Patients with stage III-IV disease had a significantly higher pretreatment CAR than patients with stage I-II disease [respectively 1.83±0.52 standard deviation (SD) and 0.58±0.38 (SD), p<0.01]. ROC analysis of overall survival of larynx squamous cell carcinoma revealed that CAR had a greater area under curve value (0.786) compared to NLR (0.695) (p<0.01). Conclusion: CAR is an independent prognostic marker in larynx cancer after being adjusted by other accompanying factors and the CAR could be a readily available biomarker in clinical setting.Geçtiğimiz on yıl boyunca, klinik onkoloji alanında enflamasyon temelli birkaç prognostik sistem bildirilmiştir. Son zamanlarda, C-reaktif protein ve albümin oranı (CAO), çok çeşitli tümör tipleri üzerinde prognostik belirteç olarak kendini göstermiştir. Bu çalışmanın amacı, larinks kanseri nedeniyle opere edilen hastalarda CAO’nun prognoz ve 5 yıllık sağkalım üzerine etkisini değerlendirmektir. Yöntem: 2010-2015 yılları arasında merkezimizde ameliyat edilen 118 hasta retrospektif analiz için uygun bulunmuştur. CAO ve nötrofil lenfosit oranın (NLO) 5 yıllık sağkalım üzerindeki etkisi değerlendirildi. CAO ile sağkalım ve prognoz arasındaki ilişkileri belirlemek için tek değişkenli ve çok değişkenli Cox regresyon analizi yapıldı. Bulgular: CAO’nun optimal cut-off seviyesi 0,993 olarak hesaplandı. Hastaların sırasıyla %40,7 ve %59,3’ünde düşük ve yüksek CAO saptandı. Yüksek CAO’lu hastaların 5 yıllık sağkalım oranları düşük gruptakilere göre daha kötü idi (%79,2’ye karşı %73,2, p<0,05). Hastalık evresi (p<0,001) ve yüksek NLO değeri de 5 yıllık sağkalım için anlamlı faktörler olarak izlendi. Tanıda CAO kötü prognoz ile ilişkili idi. Evre III-IV hastalığı olan hastalar, evre I-II hastalığı olanlara göre anlamlı olarak daha yüksek bir ameliyat öncesi CAO’ya [sırasıyla 1,83±0,52 standart sapma (SS) ve 0,58±0,38 (SS), p<0,01] sahipti. Gırtlak skuamöz hücreli karsinomun genel sağkalımının ROC analizi, CAO’nun NLO’ya (0,695) kıyasla daha yüksek (eğri altındaki alan) eğri altındaki alan değerine (0,786) sahip olduğunu ortaya koydu (p<0,01). Sonuç: CAO, eşlik eden diğer faktörlerden bağımsız olarak, larinks kanserinde bir prognostik faktördür ve CAO klinik ortamda kullanıma hazır bir biyobelirteç olabilir

Existence of SARS-CoV-2 RNA on ambient particulate matter samples: A nationwide study in Turkey

Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus and has been affecting the world since the end of 2019. The disease led to significant mortality and morbidity in Turkey, since the first case was reported on March 11th, 2020. Studies suggest a positive association between air pollution and SARS-CoV-2 infection. The aim of the present study was to investigate the role of ambient particulate matters (PM), as potential carriers for SARS-CoV-2. Ambient PM samples in various size ranges were collected from 13 sites including urban and urban-background locations and hospital gardens in 10 cities across Turkey between 13th of May and 14th of June 2020 to investigate the possible presence of SARS-CoV-2 RNA on ambient PM. A total of 203 daily samples (TSP, n = 80; PM2.5, n = 33; PM2.5-10, n = 23: PM10 mu m, n = 19; and 6 size segregated PM, n = 48) were collected using various samplers. The N1 gene and RdRP gene expressions were analyzed for the presence of SARS-CoV-2, as suggested by the Centers for Disease Control and Prevention (CDC). According to real time (RT)-PCR and three-dimensional (3D) digital (d) PCR analysis, dual RdRP and NI gene positivity were detected in 20 (9.8%) samples. Ambient PM-bound SARS-CoV-2 was analyzed quantitatively and the air concentrations of the virus ranged from 0.1 copies/m(3) to 23 copies/m(3). The highest percentages of virus detection on PM samples were from hospital gardens in Tekirdag, Zonguldak, and Istanbul, especially in PM2.5 mode. Findings of this study have suggested that SARS-CoV-2 may be transported by ambient partides, especially at sites close to the infection hot-spots. However. whether this has an impact on the spread of the virus infection remains to be determined. (C) 2021 Elsevier B.V. All rights reserved