Renal Anomalies Associated with Ectopic Neurohypophysis

Objective: Although the etiology of ectopic neurohypophysis that leads to pituitary hormone deficiencies is not yet clearly understood, birth trauma or genetic factors have been considered responsible. Concurrent cranial and extracranial congenital anomalies have been reported in such cases. The aim of the present study was to investigate the frequency of renal anomalies in nonsyndromic cases with ectopic neurohypophysis

A Randomized Clinical Trial Comparing Breakfast and Bedtime Administration of Insulin Glargine in Children and Adolescents with Type 1 Diabetes

Background: Insulin glargine provides effective glycemic control when administered at bedtime in adults

Ghrelin Levels in Children with Constitutional Delay of Growth and Puberty

Objective: In this study, we aimed to show the role of ghrelin in growth delay in children with constitutional delay of growth and puberty (CDGP)

Clinical Course of Hashimoto's Thyroiditis and Effects of Levothyroxine Therapy on the Clinical Course of the Disease in Children and Adolescents

Objective: The aim of this study was to evaluate the clinical course of Hashimoto’s thyroiditis (HT) in children and adolescents and the effects of levothyroxine therapy on the clinical course and laboratory findings

Evaluation of Permanent Growth Hormone Deficiency (GHD) in Young Adults with Childhood Onset GHD: A multicenter study

Background: Reconfirming the diagnosis of childhood onset growth hormone deficiency (GHD) in young adults is necessary to demonstrate the need for continuation of GH therapy

Bannayan-Riley-Ruvalcaba Syndrome in a Case Evaluated Due to Multinodular Goiter

Bannayan-Rıley-Ruvalcaba syndrome (BRRS) is characterized by macrocephaly, pigmented macules on the glans penis and benign mesodermal hamartomas. 9.6-year-old boy was referred to the pediatric surgeon following an observation of a subcutaneous lipomatous lesion and numerous nodules in the thyroid gland via ultrasonography performed due to swelling in the neck first noticed approximately 3 months previously. Thyroid ultrasonography revealed numerous nodules with distinct margins in both lobes of the thyroid gland, some exhibiting calcification and others hypoechoic areas, and a total thyroidectomy was performed due to a suspicion of malignity. After surgery, the patient was referred to the Pediatric Endocrinology Department. On physical examination, his weight was 30 kg [standard deviation score (SDS): -0.38], height 140 cm (SDS: 0.71) and head circumference 59.5 cm (SDS: +3.21). Pubic hair was Tanner stage 2, bilateral testes 3+3 mL palpable. There was multiple hyperpigmented lesions on the penile skin. His past medical history revealed that pubic hair development was reported at the age of 8 years. Laboratory examinations revealed a 17-OH progesterone level of 4.8 ng/mL, bone age compatible with 8 years. P. V281L heterozygous mutation was determined via CYP21A2 mutation screening performed for non-classic congenital adrenal hyperplasia. BRRS was primarily suspected in this case of macrocephaly, lipomatous lesions and pigmented macular lesions on the penis. Heterozygous p.C136R mutation was determined via PTEN mutation scanning

Pediatric Bilateral Pheochromocytoma and Experience of Laparoscopic Cortical Sparing Adrenalectomy

Pheochromocytomas are neuroendocrine tumors. In this report, we present a 15-year-old girl who had cerebral palsy and pheochromocytoma. She also had a diagnosis of hyperinsulinemic hypoglycemia in her history. She underwent bilateral laparoscopic cortical sparing adrenalectomy. We report the experience of laparoscopic bilateral cortical sparing adrenalectomy of a pediatric pheochromocytoma

Serum IGF-1 and IGFBP-3 Levels in Healthy Children Between 0 and 6 Years of Age

Objective: Along with growth hormone (GH) levels, measurements of serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) are used in the diagnosis of GH deficiency and in monitoring the efficacy and safety of long-term GH treatment. The purpose of the present study was to establish reference values for serum IGF-1 and IGFBP-3 in healthy Turkish children less than 6 years of age

Çocukluk ve ergenlik döneminde büyüme hormonu eksikliği tanı ve tedavisi uzlaşı raporu (Bölüm 2) büyüme hormonu eksikliği tedavisi

Growth hormone (GH) treatment results in normalization of final height in growth hormone deficiency of childhood. There are various aspects of growth hormone treatment that have to be taken into consideration in order to optimize final height of the children with growth hormone deficiency on GH treatment. This summary statement from the National Pediatric Endocrinology Association aims to provide guidelines for the use of GH in childhood and adolescence based on the evidence from the literature and experience of the treating physicians in Turkey.Büyüme hormonu eksikliğinde büyüme hormonu (BH) tedavisi ile nihai boyun normal sınırlar içine geldiği çeşitli çalışmalarda gösterilmiştir. Ancak, büyüme hormonu tedavisinin etkin olabilmesi için çeşitli faktörlerin (BH dozu, başlama yaşı, verilme sıklığı gibi) göz önüne alınması ve değerlendirilmesi gerekmektedir. Bu yazıda çocukluk ve adolesan döneminde büyüme hormonu eksikliğinin tedavisi ile ilgili olarak kanıtlara ve uzmanların görüşlerine dayanarak Türkiye’deki Ulusal Pediyatrik Endokrinoloji Derneği’nin önerileri sunulmuştur