Displacement Mapping with Virtual Textures

Tato práce se zabýva technikou přidávání nerovností povrchu modelů nazvanou displacement mapping s využitím virtuálních textur. Displacement mapping bude výkonnostně i vizuálně porovnán s normal mappingem. Práce dále obsahuje stručný přehled některých světelných modelů a předcházejících metod pro simulování nerovností povrchů.This thesis describes technique for adding roughness to surface of models called displacement mapping with virtual textures. Efficiency and visual quality of displacement mapping will be compared to normal mapping. Thesis also briefly describes some of lightning models and former techniques for adding details to smooth surface.

Displacement Mapping with Virtual Textures

This thesis describes technique for adding roughness to surface of models called displacement mapping with virtual textures. Efficiency and visual quality of displacement mapping will be compared to normal mapping. Thesis also briefly describes some of lightning models and former techniques for adding details to smooth surface

Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis

Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization of dissolution compartments/vessels for an updated version of the biorelevant dissolution apparatus—Golem v2. We designed eight compartments of uniform size but different inner geometry. The dissolution performance of the compartments was tested using immediate release caffeine tablets and evaluated by standard statistical methods and principal component analysis. Based on two phases of dissolution testing (using 250 and 100 mL of dissolution medium), we selected two compartment types yielding the highest measurement reproducibility. We also confirmed a statistically ssignificant effect of agitation rate and dissolution volume on the extent of drug dissolved and measurement reproducibility

Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study

Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in various pharmaceutical fields of interest. We aimed to explore its application in hypromellose matrix systems (HPMC content 10–30%) compared to the traditionally used microcrystalline cellulose (MCC) PH 102. The properties of powder mixtures and directly compressed tablets containing individual fillers NEU or MCC, or their blend with ratios of 1.5:1, 1:1, and 0.5:1 were investigated. Besides the routine pharmaceutical testing, we have enriched the matrices’ evaluation with a biorelevant dynamic dissolution study and advanced statistical analysis. Under the USP apparatus 2 dissolution test, NEU, individually, did not provide advantages compared to MCC. The primary limitations were the burst effect increase followed by faster drug release at the 10–20% HPMC concentrations. However, the biorelevant dynamic dissolution study did not confirm these findings and showed similarities in dissolution profiles. It indicates the limitations of pharmacopoeial methods in matrix tablet development. Surprisingly, the NEU/MCC blend matrices at the same HPMC concentration showed technologically advantageous properties. Besides improved flowability, tablet hardness, and a positive impact on the in vitro drug dissolution profile toward zero-order kinetics, the USP 2 dissolution data of the samples N75M50 and N50M50 showed a similarity to those obtained from the dynamic biorelevant apparatus with multi-compartment structure. This finding demonstrates the more predictable in vivo behaviour of the developed matrix systems in human organisms

Synthesis of polymer particles by emulsifier-free emulsion polymerization and rheological behavior of model filled polymers. - Page 238

In this work we compare the pulse-shape discrimination (PSD) properties of EJ-299-33A, BC-501A, stilbene, p-terphenyl and Hidex Aqualight in neutron field generated by the LVR-15 reactor with silicon filter utilization. Pulses from the scintillators are processed by Neutron-Gamma spectrometer. This spectrometric system with fast digitizer card contains two analog-digital (A/D) converters with a resolution of 12 bits and sampling frequency 500 MHz. For photomultiplier (PMT) linearity improvement active divider has been used. Measured data from scintillators have been processed using the integration method and compared. Results are presented

Andre Hall and Watson Hall

This image was done for the centenary of the College.https://research.avondale.edu.au/main_image_gallery/1004/thumbnail.jp