Hypogammaglobulinemia Prevelance in Children with Atopic Dermatitis and the Relationship Between Immunoglobulin Levels and Eczema Severity

Aim:Atopic dermatitis (AD) is the most common chronic skin disease of childhood. Although eczema may be a prominent finding in some primary immune deficiencies, there are very few studies conducted on the frequency of hypogammaglobulinemia in patients with eczema. In our study, we aimed to determine the frequency of hypogammaglobulinemia in patients with AD and the relationship between immunoglobulin levels and eczema severity.Materials and Methods:Patients between the ages of 0-18 years, who were diagnosed with AD between January 2015 and August 2018 in the Department Pediatrics Division of Pediatric Allergy and Immunology, Trakya University Faculty of Medicine, were included in the study. Hypogammaglobulinemia was defined as being less than -2 standard deviation of immunoglobulin A, M and G from normal values for age.Results:The median age of 117 patients included in the study was 11 months [interquartile range (IQR): 6.7-33 months], the median age of eczema onset was 3.5 months (IQR: 2-6 months), the median SCORingAtopicDermatitis at presentation was 13.8 (IQR): 5-32]. Thirty-six (30.8%) patients had low levels in one of the immunoglobulin isotypes and decreased levels of immunoglobulin A (IgA), M and G were found in 21 (17.9%), 18 (15.5%) and 23 (19.7%) patients, respectively. While there was no difference between mild and moderate-severe eczema groups in terms of age at presentation, age of onset of eczema, family history of allergic diseases, smoking exposure, aeroallergen sensitivity, food allergy, the number of patients having hypogammaglobulinemia, and the levels of IgA, M and G, a male predominance and higher number of eosinophils were observed in the moderate-severe eczema group.Conclusion:It is concluded that the evaluation of immunoglobulin levels independent of the severity of eczema is important for the distinction of primary immunodeficiency and the follow-up of patients in terms of transient hypogammaglobulinemia of infancy in patients with AD

Residents and interns in the 3 university hospitals: their knowledge of and attitudes to drug allergy

Background: Previous studies revealed there are many gaps in the awareness and knowledge regarding the diagnosis and management of drug allergy (DA) among various health-care professionals. Objective: To assess the knowledge, attitudes, and practices towards DA among residents and interns of 3 university hospitals in the region of Trakya (Thrace), Turkey. Methods: A cross-sectional survey was conducted at university hospitals of 3 cities in the Trakya region: 1. Trakya University Medical Faculty, Edirne (n = 405), 2. Namik Kemal University Medical Faculty, Tekirdag (n = 114), and 3. Canakkale 18 Mart University Medical Faculty, Canakkale (n = 111). A Turkish questionnaire was developed based on previous published studies. Results: The majority of participants (67%) had not received education on DA as a separate subject during their medical education. Less than a third (28.3%) of all respondents were satisfied with their knowledge concerning patients with clinical signs of DA. Of the 6 knowledge questions on DA, the average score for the study was 3.51 out of 6 (58.5%). Residents had a higher knowledge score (3.93 +/- 1.1) compared with interns (3.05 +/- 1.2) (p < 0.001). The lowest percentage of correct answers were in response to questions on laboratory confirmation of drug-related anaphylaxis (14.5%) and the possibility of penicillin toleration in patients with a history of penicillin allergy (11.8%). The majority of participants (92%) believe that medical doctors should be educated in DA. There were no significant correlations between taking DA histories and the frequency during daily practice of encountering patients. Conclusion: Our study revealed that DA knowledge and attitudes are not at satisfactory level among respondents, and we concluded the importance and necessity of reinforcement of DA education in pre- and postgraduate education of medical doctors

Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Retrospective evaluation of patients who admitted to our department with drug reaction

Tıpta Uzmanlık Teziİlaç reaksiyonları önemli morbidite ve mortalite sebepleri arasındadır. Çocuk yaş grubunda hastanede yatanlar içinde ilaç reaksiyonlarının insidansını araştıran çalışmalarda bu oran %0.6 ile %42 arasında değişmektedir. Ayaktan bakılan hastalarda ise insidans %1 ile %14 arasında değişmektedir. Bu çalışmada Aralık 2009-Ağustos 2011 tarihleri arasında Trakya Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk İmmünolojisi ve Allerji Hastalıkları Bilim Dalı'na ilaç reaksiyonu nedeniyle başvuran veya ilaç reaksiyonu nedeniyle Çocuk Sağlığı ve Hastalıkları Anabilim Dalı'na ait diğer birimlerden konsülte edilen olgulara ait verilerin retrospektif olarak değerlendirilmesi yapılmış olup yatan hastalardaki ilaç reaksiyonu insidansı %0.38 (18/4725); olarak saptanmıştır. Ayaktan bakılan hastalarda ilaç reaksiyonu insidansı %0.49 (78/15640); hastaneye yatış gerektiren reaksiyonların insidansı %0.1 (17/15640); toplam insidans %0.47 (96/20365) olarak belirlenmiştir. İlaç reaksiyonları içerisinde hastaneye yatış gerektiren 17 (%14.5) reaksiyon gözlenmiştir. Reaksiyonlar ciddiyet açısından değerlendirildiğinde 12 reaksiyon (%10.26) hafif, 96 reaksiyon (%82.05) orta, ve 9 reaksiyon (%7.69) ağır olarak değerlendirildi. Ağır reaksiyon gözlenen olgularımızın %44.4'ünde öyküde allerjik hastalık saptanmış olup, bunların %75'inin astım olduğu belirlendi. Reaksiyonlara neden olan ilaç etken meddelerini araştırdığımızda 117 reaksiyonda (%100) etken madde belirlendi. Reaksiyonlara en sık neden olan ilaç grubu 94 reaksiyonda (%80.34) etken olarak belirlenen beta laktam antibiyotikler idi. Beta laktam antibiyotikler içinde amoksisilin klavulonat en sık sorumlu etken olarak saptandı. İlaç reaksiyonları'nın çocuklarda neden olduğu morbidite, mortalite ve yarttığı ekonomik kayıplara ilişkin veriler arttıkça konu ile ilgili çalışmaların gerekliliği daha iyi anlaşılmaktadır. Çocuklarda ilaç reaksiyonlarına ilişkin epidemiyolojik ve demografik özelliklerin belirlenmesi reaksiyonlarda izlenecek yaklaşımın yanısıra; önlenebilirliği açısından da yararlı bilgiler sağlayabilir.AbstractDrug reactions are important causes of mortality and morbidity. The percentage in studies investigating incidence of drug reactions in hospitalized children changes between 0.6% and 42% . The incidence in outpatients is between 1% and 14%. In this study, data of children who admitted, referred or consulted to our pediatric allergy ımmunology department due to drug reactions were evaluated retrospectively. The incidence of drug reaction in hospitalized patients is 0.38% (18/4725). The incidence of drug reaction in outpatients is 0.49% (78/15640), the incidence of drug reaction causing hospital admission is 0.1% (17/15640) and total incidence was 0.47% (96/20365). Seventeen drug reactions (14.5%) requiring hospitalization were observed. 12 reactions were evaluated mild, 96 reactions moderate and 9 reactions severe according to seriousness. 44.4 % of our patients who had severe reaction, had a history of allergic disease in their past. 75 % of them were reported as asthma. In 117 (100%) of drug reactions culprit drug were identified. The most common drug causing to reactions was beta-lactams that were identified in 94 (80.34%) reactions. Amoxicillin-clavulanic acid is the most common responsible agent in beta lactam antibiotics. As the datas related to the mortality, morbidity and economic burden of drug reactions in children increases, the need for studies on this subject is better understood. Identification of drug reactions epidemiological and demographic characteristics can be helpful in determining the approach and preventability of drug reactions

Knowledge and attitudes regarding drug allergy among residents and interns in Tracia region of Turkey; a multicenter study

Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- JUN 01-05, 2019 -- Lisbon, PORTUGAL[No Abstract Available]European Acad Allergy & Clin Immuno