Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD

Background/aim: To investigate total oxidant and antioxidant status, maximal aerobic capacity, daily physical activity, pulmonary functions, and body composition changes, as well as the associations among these parameters, in patients with mild to moderate chronic obstructive pulmonary disease (COPD) versus healthy controls. Materials and methods: The study included 30 male patients newly diagnosed with COPD and 30 body mass index-matched, nonsmoker male controls. Maximal aerobic capacity, daily physical activity, total oxidant and antioxidant status, pulmonary function tests, body composition, and anthropometric parameters were measured. Results: Maximal aerobic capacity and total antioxidant values were lower in patients with COPD compared to the controls. The total oxidant value, body fat percentage, and waist/hip ratio were higher in patients with COPD than in the healthy controls. There was a moderately negative correlation between the total oxidant value and the maximal aerobic capacity, while there was a moderately positive correlation between the total antioxidant values and maximal aerobic capacity in patients with COPD. Conclusion: Low aerobic capacity, increased oxidative stress, and adiposity are related to impaired pulmonary functions in patients with mild to moderate COPD and might have a role in the pathogenesis of COPD.Afyon Kocatepe University Scientific Research Projects CommitteeAfyon Kocatepe University [09.TIP.06]This study was supported by the Afyon Kocatepe University Scientific Research Projects Committee (Project No.: 09.TIP.06)

Gastrointestinal sistem endoskopilerinde ve perkutan karaciğer iğne biyopsilerinde bakteriemi nisbeti

TEZ13Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 1976.Kaynakça (s. 43-45) var.45 s. : res. ; 30 cm.

Osteoporoz ve Osteopenili Olgularda Pulmoner Fonksiyonlar ve Yaflam Kalitesi

Amaç:&nbsp;Osteoporoza ba¤l› vertebral k›r›klar ve kifoz aç›s›nda art›fla ba¤l› solunum fonksiyonlar›nda bozulmalar olabilir. Amac›m›z osteoporozu olan hastalar›n solunum fonksiyonlar›n› ve yaflam kalitelerini de¤erlendirmektir.Gereç ve Yöntem:&nbsp;Çal›flmam›za poliklini¤imizde takip edilen 51 osteoporoz (49 kad›n, 2 erkek) ve 19 osteopenik kifli (18 kad›n, 1 er- kek) al›nd›. Kat›l›mc›lar›n demografik özellikleri kaydedildi, solunum fonksiyon testi (SFT) yap›ld› ve dorsal lateral grafileri çekilerek Cobb aç›s› ölçüldü. Genel vücut a¤r›s› Vizüel Analog Skala (VAS) ile, yaflam kalitesi Short Form-36 (SF-36) anketi ile de¤erlendirildi.&nbsp;Bulgular:&nbsp;Yafl ortalamas› osteoporoz grubunda 63,3±8,7, osteopeni grubunda 55,3±7,3 y›l idi (p=0,001). Osteoporoz grubunun vü- cut kitle indeksi, osteopeni grubuna göre anlaml› olarak daha düflüktü (s›ras›yla 28,8±5,7, 32,2±5,5, p=0,029). Osteoporoz grubun- da osteopeni grubuna göre ölçülen birinci saniyedeki zorlu ekspirasyon volümü (FEV1) (s›ras›yla 1,8±0,4, 2,1±0,5, p=0,018) ve ölçü- len zorlu vital kapasite (FVC) (s›ras›yla 2,2±0,5, 2,6±0,6, p=0,005) de¤erleri anlaml› olarak daha düflük bulundu. ‹ki grup aras›nda di- ¤er SFT parametreleri aç›s›ndan anlaml› farkl›l›k saptanmad›. Ortalama Cobb aç›s› osteoporoz grubunda osteopeni grubuna göre daha yüksekti, ancak aralar›ndaki farkl›l›k istatistiksel anlaml› bulunmad› (s›ras›yla 32,7±12,4, 28,5±9,5, p=0,194). Tüm hastalar de- ¤erlendirildi¤inde Cobb aç›s› ile SFT parametreleri aras›nda anlaml› korelasyon saptanmad› (p&gt;0,05). Her iki grubun VAS ve SF-36 anketi skorlar› aras›nda anlaml› farkl›l›k saptanmad› (p&gt;0,05).Sonuç:&nbsp;Osteoporoz grubunda osteopeni grubuna göre solunum fonksiyonlar›ndan ölçülen FEV1&nbsp;ve ölçülen FVC de¤erlerini anlam- l› olarak daha düflük bulduk. Ancak %FEV1&nbsp;ve %FVC de¤erleri aras›nda anlaml› farkl›l›k saptamad›k. Osteopeni grubunun daha genç ve daha kilolu olmas›ndan dolay› ölçülen de¤erlerdeki farkl›l›klar›n olufltu¤unu düflündük. Kifoz aç›s› ortalamas› çal›flmam›z- daki kadar olan osteoporoz hastalar›n›n solunum fonksiyonlar› ve yaflam kaliteleri osteopenik kiflilerden daha kötü de¤ildir.&nbsp;(Osteoporoz Dünyas›ndan 2009;15:11-5)Anahtar kelimeler:&nbsp;Osteoporoz, kifoz, pulmoner fonksiyon, yaflam kalitesiAim:&nbsp;Osteoporotic vertebral fractures and increased kyphotic angle may cause disturbances in pulmonary functions. Our aim was to evaluate pulmonary function and quality of life in osteoporotic patients.Material and Methods:&nbsp;Fifty-one patients with osteoporosis and 19 osteopenic subject, followed in our outpatient clinic, we- re included. Their demographics were recorded. All the subjects were submitted to pulmonary function test (PFT) and dorsal lateral radiography was obtained to measure Cobb angle. Global body pain was assessed using Visual Analogue Scale (VAS) and quality of life was assessed using Short Form-36 (SF-36) questionnaire.Results:&nbsp;The mean ages were 63.3±8.7 in osteoporosis and 55.3±7.3 in osteopenia groups (p=0.001). Body mass index of the osteoporosis group was significantly lower than osteopenia group (28.8±5.7 and 32.2±5.5, respectively, p=0.029). In osteopo- rosis group compared to osteopenia group, the absolute forced expiratory volume in 1 second (FEV1) (1.8±0.4 and 2.1±0.5, respectively, p=0.018) and absolute forced vital capacity (FVC) (2.2±0.5 and 2.6±0.6, respectively, p=0.005) were significantly lower. No differences were found between two groups concerning other PFT parameters. The mean Cobb angle was higher in osteoporosis group than osteopenia group, but the difference was not significant (32.7±12.4 and 28.5±9.5, respectively,&nbsp;p=0.194). When all the subjects were considered, no correlation was found between Cobb angle and PFT parameters (p&gt;0.05). No significant difference was found between two groups in respect to VAS and SF-36 scores (p&gt;0.05).&nbsp;Conclusion:&nbsp;We found absolute FEV1&nbsp;and absolute FVC significantly lower in osteoporosis group compared to osteopenia group. But we observed no differences in % predicted FEV1&nbsp;and % predicted FVC. We supposed that the differences we- re because the subjects in osteopenia group were younger and fatter. The pulmonary functions and quality of life of the osteoporotic patients with a kyphotic angle up to studied are not worse than the osteopenic people.&nbsp;(From the World of Osteoporosis 2009;15:11-5)Key words:&nbsp;Osteoporosis, kyphosis, pulmonary function, quality of life</div

Pulmonary Functions and Quality of Life in Osteoporotic and Osteopenic Subjects - Original Investigation

Aim: Osteoporotic vertebral fractures and increased kyphotic angle may cause disturbances in pulmonary functions. Our aim was to evaluate pulmonary function and quality of life in osteoporotic patients. Material and Methods: Fifty-one patients with osteoporosis and 19 osteopenic subject, followed in our outpatient clinic, were included. Their demographics were recorded. All the subjects were submitted to pulmonary function test (PFT) and dorsal lateral radiography was obtained to measure Cobb angle. Global body pain was assessed using Visual Analogue Scale (VAS) and quality of life was assessed using Short Form-36 (SF-36) questionnaire. Results: The mean ages were 63.3±8.7 in osteoporosis and 55.3±7.3 in osteopenia groups (p=0.001). Body mass index of the osteoporosis group was significantly lower than osteopenia group (28.8±5.7 and 32.2±5.5, respectively, p=0.029). In osteoporosis group compared to osteopenia group, the absolute forced expiratory volume in 1 second (FEV1) (1.8±0.4 and 2.1±0.5, respectively, p=0.018) and absolute forced vital capacity (FVC) (2.2±0.5 and 2.6±0.6, respectively, p=0.005) were significantly lower. No differences were found between two groups concerning other PFT parameters. The mean Cobb angle was higher in osteoporosis group than osteopenia group, but the difference was not significant (32.7±12.4 and 28.5±9.5, respectively, p=0.194). When all the subjects were considered, no correlation was found between Cobb angle and PFT parameters (p>0.05). No significant difference was found between two groups in respect to VAS and SF-36 scores (p>0.05). Conclusion: We found absolute FEV1 and absolute FVC significantly lower in osteoporosis group compared to osteopenia group. But we observed no differences in % predicted FEV1 and % predicted FVC. We supposed that the differences were because the subjects in osteopenia group were younger and fatter. The pulmonary functions and quality of life of the osteoporotic patients with a kyphotic angle up to studied are not worse than the osteopenic people. (From the World of Osteoporosis 2009;15:11-5