Determination of benazepril HCl and hydrochlorothiazide in pharmaceutical preparations using UV-visible spectrophotometry and genetic multivariate calibration method

Simultaneous determination of binary mixtures of benazepril and hydrochlorothiazide in pharmaceutical tablets using UV-visible spectrophotometry, classical least squares (CLS) and three genetic algorithms (GA) based multivariate calibration methods was demonstrated. The three genetic multivariate calibration methods are Genetic Classical Least Squares (GCLS), Genetic Inverse Least Squares (GILS) and Genetic Regression (GR). The sample data set contains the UV- spectra of 28 synthetic mixtures of benazepril (12∼36 μg/mL) and hydrochlorothiazide (10∼22 μg/mL) and 16 tablets containing both compounds. The spectra cover the range from 210 to 360 nm in 0.1 mn intervals. Several calibration models were built with the four methods. The root mean square error of calibration (RMSEC) and validation (RMSEV) for the synthetic data were in the range of 0.19 and 0.34 μg/mL for all the genetic algorithm based methods. The root mean square error of Prediction (RMSEP) values for the tablets were in the range of 0.04∼0.20 mg/tablets. A comparison of genetic algorithm selected wavelengths for each component was also included

THE ROLE OF THE MUSIC IN COPING WITH TRAUMA EXPERIENCES

Trauma experiences, is a significant risk factor for mental health. Considering the prevalence of traumatic events, the effectiveness of the coping strategies used by individuals who have been exposed or witnessed these events is becoming more important. The purpose of this study is to examine the role of listening to music in coping with trauma. The research was tailored to the case study from qualitative research methods. The study group of the research consists of seven students having at least one traumatic experience and studying at a high school in the province of Rize. A semi-structured interview form consisting of 8 questions was used as the basic data collection tool in the study. The obtained data were analyzed by using qualitative data analysis techniques and content analysis technique. Analyzes made indicates that a large number of participants have tried to listen to music to cope with trauma experiences. In the process of coping with trauma, it has been determined that listening to music has neutral, positive and negative effects. It is considered that the results obtained will provide meaningful contributions to the preparation of intervention programs for individuals with traumatic experiences.  Article visualizations

Continuous wavelet transform methods for the simultaneous determinations and dissolution profiles of valsartan and hydrochlorothiazide in tablets

Continuous wavelet transform (CWT) was proposed for the simultaneous determination and dissolution profiles of valsartan (VAL) and hydrochlorothiazide (HCT) in tablets, without the use of a chemical separation procedure. The CWT approach was applied to the original UV spectra and their ratio spectra in the optimal wavelength ranges. After testing several wavelet families, Mexican hat function-CWT and Daubechies7-CWT (mexh-CWT and db7-CWT, respectively) were found to be suitable for the transformation of the original UV spectra. In the following procedure, mexh-CWT and Coiflets3-CWT (coif3-CWT) were found to be appropriate for the signal analysis of ratio spectra (RS) of VAL/HCT and HCT/VAL. Calibration graphs for VAL and HCT were obtained by measuring db7-CWT and mexh-CWT amplitudes in the transformation of the original absorption spectra and RS-coif-CWT and RS-mexh-CWT amplitudes in the transformation of the ratio spectra. The validity and applicability of the proposed CWT methods were evaluated through the analysis of an independent set of synthetic binary mixtures consisting of VAL and HCT. The proposed signal processing methods were then successfully applied to the simultaneous quantitative evaluation and simultaneous dissolution profiles of the related drugs in commercial tablets, with good agreement reported for the experimental results

Comparison of Satisfaction of Body Parts and the Success Levels of the Teams That Participated in Universities Handball 2nd League Competitions

The study was conducted to determine and compare the satisfaction levels of the students participating in the Universities 2nd Handball League competitions on body parts and body features and the success of their teams. The study group consisted of n=213 (111 female, 102 male) students between 18-24 years of age who participated in 2016-2017 Universities 2nd Handball League competitions (8 Female Teams, 8 Male Teams). The “Body Parts and Body Features Satisfaction Scale” was used as the measurement tool. There are 26 items for women and 27 items for men in this scale. The One-Way Variance Analysis and Tukey Test were used in the comparison of the satisfaction scores of the male handball players from their body parts with the success levels in competitions, and the Kruskal Wallis Test and Mann Whitney U-Test were used in female participants.According to the satisfaction from body parts and features average scores, the differences between the male and female teams were found to be statistically significant (p<0,05). These differences were detected in İbrahim Çeçen, Erzincan and Doğu Akdeniz University teams in men; and in Atatürk, Sütçü İmam and Erciyes University teams in women.As a result, although there was a statistically significant difference between the average satisfaction scores of the teams, which were the 1st and the last in the tournament, in terms of body parts and features, it was also determined that this situation was not influential on the success rating of the teams

Okul yöneticilerinin eğitimde dönüştürücü liderlik özellikleri

Bu çalışmada lider ve yöneticilik ile ilgili olarak okul yöneticilerinin yönetim anlayışları, yönetim şekillerine bağlı gelişen olası sonuçlar ve dönüştürücü liderlik ele alınmaktadır. Günümüzde örgütlerin içinde bulunduğu hızlı dönüşüm ve teknolojik gelişmeler liderin örgüt başarısını önemli ölçüde etkileyen bir unsur olmasını sağlamıştır. Dolayısıyla modern liderlik anlayışları da liderin işbirlikçi, örgüt başarısını ve ortak hedefleri önceleyen bir anlayışı gerektirmektedir. Modern liderlik anlayışlarından dönüştürücü liderlik örgüte ilişkin görev ve hedef belirleme, personellerin bireysel çıkarlarından ziyade ortak faydalar sağlama gibi örgüt başarısını artırıcı etkiler doğurmaktadır. Bu çerçevede okul örgütünün liderleri olarak okul yöneticileri de personelin katılımcı, ortak hedeflere yönelmiş ve okul başarısını artırmayı hedefleyen, çalışma motivasyonuyla donatılmış kişiler olmasında katkı sağlamaktadır. Bu çalışmada liderlik ve özellikle dönüştürücü liderlik ile ilgili kaynak taraması yapılmış ve bu amaçla literatürde yer alan kaynaklardan faydalanılmıştır. Yapılan araştırma, öğretim liderliğinin önemini, öğretim liderliği ile öğrenci başarısı arasındaki temel ilişkiyi ve başarılı bir okul yönetiminin işbirlikçi uygulamalar üzerindeki gücünü vurgulamaktadır

Effect of Continuous Positive Airway Pressure on Overactive Bladder Symptoms in Patients with Obstructive Sleep Apnea Syndrome

Objective:To evaluate overactive bladder (OAB) in male and female patients with moderate or severe obstructive sleep apnea syndrome (OSAS) and to investigate the impact of three months of continuous positive airwMethods:Twenty-eight female and 45 male patients with moderate and severe OSAS whose obstructive sleep apnea (OSA) severity was evaluated according to the apnea–hypopnea index were included in the study. Patients’ voiding symptoms were evaluated using the validated Turkish translations of overactive bladder symptom scores (OAB-V8) and the International Consultation on Incontinence Questionnaire Short-Form (ICIQ-SF) at OSAS diagnosis and at 3-months after the CPAP therapy.Results:Patients with moderate and severe OSAS were more likely to have OAB than the average population, and CPAP therapy improved the symptoms of OAB in both male and female patients. In addition, a positive association was observed between OSA severity and OAB-V8 and ICIQ-SF in female patients and between OSA severity and OAB-V8 in male patients.Conclusion:Our findings suggest that CPAP therapy improves the clinical symptoms of OAB. Thus, unnecessary medical or interventional treatment of OAB can be avoided in such patients

Continuous wavelet transform methods for the simultaneous determinations and dissolution profiles of valsartan and hydrochlorothiazide in tablets

ABSTRACT Continuous wavelet transform (CWT) was proposed for the simultaneous determination and dissolution profiles of valsartan (VAL) and hydrochlorothiazide (HCT) in tablets, without the use of a chemical separation procedure. The CWT approach was applied to the original UV spectra and their ratio spectra in the optimal wavelength ranges. After testing several wavelet families, Mexican hat function-CWT and Daubechies7-CWT (mexh-CWT and db7-CWT, respectively) were found to be suitable for the transformation of the original UV spectra. In the following procedure, mexh-CWT and Coiflets3-CWT (coif3-CWT) were found to be appropriate for the signal analysis of ratio spectra (RS) of VAL/HCT and HCT/VAL. Calibration graphs for VAL and HCT were obtained by measuring db7-CWT and mexh-CWT amplitudes in the transformation of the original absorption spectra and RS-coif-CWT and RS-mexh-CWT amplitudes in the transformation of the ratio spectra. The validity and applicability of the proposed CWT methods were evaluated through the analysis of an independent set of synthetic binary mixtures consisting of VAL and HCT. The proposed signal processing methods were then successfully applied to the simultaneous quantitative evaluation and simultaneous dissolution profiles of the related drugs in commercial tablets, with good agreement reported for the experimental results

Outcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study

PURPOSEThe clinical management of high-risk lesions using image-guided biopsy is challenging. This study aimed to evaluate the rates at which such lesions were upgraded to malignancy and identify possible predictive factors for upgrading high-risk lesions.METHODSThis retrospective multicenter analysis included 1.343 patients diagnosed with high-risk lesions using an image-guided core needle or vacuum-assisted biopsy (VAB). Only patients managed using an excisional biopsy or with at least one year of documented radiological follow-up were included. For each, the Breast Imaging Reporting and Data System (BI-RADS) category, number of samples, needle thickness, and lesion size were correlated with malignancy upgrade rates in different histologic subtypes. Pearson’s chi-squared test, the Fisher–Freeman–Halton test, and Fisher’s exact test were used for the statistical analyses.RESULTSThe overall upgrade rate was 20.6%, with the highest rates in the subtypes of intraductal papilloma (IP) with atypia (44.7%; 55/123), followed by atypical ductal hyperplasia (ADH) (38.4%; 144/375), lobular neoplasia (LN) (12.7%; 7/55), papilloma without atypia (9.4%; 58/611), flat epithelial atypia (FEA) (8.7%; 10/114), and radial scars (RSs) (4.6%; 3/65). There was a significant relationship between the upgrade rate and BI-RADS category, number of samples, and lesion size Lesion size was the most predictive factor for an upgrade in all subtypes.CONCLUSIONADH and atypical IP showed considerable upgrade rates to malignancy, requiring surgical excision. The LN, IP without atypia, pure FEA, and RS subtypes showed lower malignancy rates when the BI-RADS category was lower and in smaller lesions that had been adequately sampled using VAB. After being discussed in a multidisciplinary meeting, these cases could be managed with follow-up instead of excision

Determination of thiamine HCl and pyridoxine HCl in pharmaceutical preparations using UV-Visible spectrophotometry and genetic algorithm based multivariate calibration methods

Simultaneous determination of binary mixtures pyridoxine hydrochloride and thiamine hydrochloride in a vitamin combination using UV-visible spectrophotometry and classical least squares (CLS) and three newly developed genetic algorithm (GA) based multivariate calibration methods was demonstrated. The three genetic multivariate calibration methods are Genetic Classical Least Squares (GCLS), Genetic Inverse Least Squares (GILS) and Genetic Regression (GR). The sample data set contains the UV-visible spectra of 30 synthetic mixtures (8 to 40 μg/ml) of these vitamins and 10 tablets containing 250 mg from each vitamin. The spectra cover the range from 200 to 330 nm in 0.1 nm intervals. Several calibration models were built with the four methods for the two components. Overall, the standard error of calibration (SEC) and the standard error of prediction (SEP) for the synthetic data were in the range of <0.01 and 0.43 μg/ml for all the four methods. The SEP values for the tablets were in the range of 2.91 and 11.51 mg/tablets. A comparison of genetic algorithm selected wavelengths for each component using GR method was also include