“The Lolelaplap (Marshall Islands) in Us: Sailing West to East (Ralik→Ratak) to These Our Atolls (Aelon Kein Ad) Ad Jolet Jen Anij (Our Blessed Inheritance from God)”

This paper discusses the expansion of Oceania through a Marshallese indigenous lens as a focal point. It explains that decolonizing methodologies allows reclaiming of space for mental liberation and reassurement of constitutional rights. It highlights similar occurrences of decolonization practices meeting resistance in the 21st century all while strengthening the human right argument that no human deserves any less than their fellow human brothers and sisters. It argues that an indigenous imagery can only be viewed through an indigenous lens where the researches’ level of purity is retained and unfiltered. It nevertheless argues that Marshallese ethnolinguistics reveal the same cultural practices in America, Judeo-Christianity, and Oceania thus dictating the reality that “we are the same not withstanding one stays here and one there (Bedbedjin Bedbedjen, Bedbedjinma wot Kwe)”. It further explains the importance in these similarities and how Marshallese spirituality predates introduced American Judeo-Christianity despite the latter attempting to marginalize the former. It concludes by stating that Marshallese contributions on the global stage are rooted in that culture of love (IaKwe) which is echoed by the custom(s) revealing the significance of Marshallese validation academically, spiritually, economically, & socially to prevent institutionalized discrimination. This paper ends stating that the agency to know one’s self and how one should fit in the world, is a human right in itself and Marshallese are entitled to this sense of self worth through knowing thy self by thy self where real thinking takes place in one’s own mind as we all live our own lives

Review of therapeutic options and the management of patients with myelodysplastic syndromes

Myelodysplastic syndromes (MDS) are a poorly understood group of disorders caused by one or more genetic aberrations in the bone marrow-derived cell line responsible for hematopoiesis. Recent advances in genetic medicine have offered new insights into the epigenesis as well as the prognosis of MDS, but have not resulted in new or improved curative treatment options. Bone marrow transplantation, introduced before the advent of genetic medicine, is still the only potential cure. Advances in other medical and pharmaceutical areas have broadened the scope of supportive care and disease-modifying therapies, and treating physicians now have a broad range of disease management options depending on a patient's likely prognosis. There is now clear evidence that appropriate supportive care and therapeutic intervention can improve progression-free and overall survival of MDS patients

Is elevated level of soluble endothelial protein C receptor a new risk factor for retinal vein occlusion?

Backround: To evaluate the systemic and thrombophilic risk factors for retinal vein occlusion (RVO) and to determine whether the elevated level of soluble endothelial protein C receptor (sEPCR) is a risk factor for thrombosis

Is elevated level of soluble endothelial protein C receptor a new risk factor for retinal vein occlusion?

Backround: To evaluate the systemic and thrombophilic risk factors for retinal vein occlusion (RVO) and to determine whether the elevated level of soluble endothelial protein C receptor (sEPCR) is a risk factor for thrombosis

Behçet Hastalığında Hormon Düzeylerinin Değerlendirilmesi

Objectives: This study aims to evaluate the basal serum levels of the hypophysial, thyroidal, adrenal, and gonadal hormones and the disease activity in patients with Behcet's disease (BD). Patients and methods: Forty-three patients (22 males, 21 females; mean age 34 years; range 21 to 46 years) were divided into the following four groups according to the disease activity and presence of ocular involvement: Active BD (n=27), inactive BD (n=16), those with ocular involvement (n=14), and those without ocular involvement (n=29). A group of 40 (18 male, 22 female) healthy subjects matched according to age and gender were used as the negative control group. A positive control group (two males and 14 females) consisted of 16 patients with systemic lupus erythematosus. Triiodothyronin, thyroxin, the thyroid-stimulating hormone, the follicle-stimulating hormone, the luteinizing hormone, the growth hormone (GH), dihydroepiandrosterone sulphate (DHEAS), estradiol, testosterone, basal cortisol, prolactin (PRL), and the adrenocorticotropic hormone were evaluated in all subjects. Results: No clinically significant differences were found between the BD groups and negative control group in terms of the basal serum levels of the hypophysial, thyroidal, adrenal, and gonadal hormones. When the hormonal values were evaluated with regard to disease activity and ocular involvement, the BD patients with ocular involvement showed significantly higher PRL and GH values in both genders and significantly lower DHEAS levels in female patients. Conclusion: Despite being a vasculitis-related disease, we can conclude that BD has no major influence on the endocrine system. Also, further, large-scale studies are needed to evaluate the correlations between PRL, GH, and DHEAS values and ocular involvement.WoSScopu

The Impact Of Eltrombopag Administration On The Clinical Course Of Severe Refractory Fatal Acquired Aplastic Anemia

PubMe

Eculizumab Before and After Allogeneic Hematopoietic Stem Cell Transplantation in a Patient With Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the triad of intravascular hemolysis, venous thrombosis, and cytopenia. Treatment of PNH is generally supportive. Bone marrow transplantation is the only curative therapy for PNH, but is associated with significant morbidity and mortality. Herein, we present a patient with PNH that received eculizumab, a humanized monoclonal antibody that blocks activation of the terminal complement at C5, before and immediately following allogeneic peripheral stem cell transplantation. Prior to hematopoietic stem cell transplantation eculizumab treatment markedly reduced hemolysis and transfusion requirement; however, 1 d post transplantation a hemolytic episode occured, which was successfully stopped with eculizumab re-treatment. Afterwards the patient did not require additional transfusions. The results of this study indicate that early administration of eculizumab may be a safe and effective therapy for hemolytic episodes associated with allogeneic peripheral stem cell transplantation in patients with PNH. (Turk J Hematol 2011; 28:223-7)WoSScopu