The marigold (Calendula officinalis L.) drug essential oil agents change under different fertilizatton settingi in small plot trial

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Expression of insulin and GLP-1 receptors in interneurons of the cerebral cortex

The action of insulin is not restricted to peripheral organs. Insulin receptors and signal transduction pathways described in the periphery are involved in a wide array of functions in the central nervous system. It is generally accepted that insulin produced by pancreatic beta cells in physiological conditions or applied intranasally with a therapeutic purpose for mild to moderate Alzheimer’s disease finds its way to neurons of the cerebral cortex. The timescale of external insulin transport to the vicinity of neurons is relatively slow, consistent with long-term homeostatic regulation of neural networks. Recent work has overwhelmingly shown that insulin is also synthesised locally in the cerebral cortex. Neuron-derived insulin is capable of rapid modulation of synaptic and microcircuit mechanisms and is suggested to regulate on-demand energy homeostasis of neural networks. Our results provide evidence for functional expression of GLP-1 receptors in neurons known to release insulin in the cerebral cortex. Hyperglycemia increases the expression of GLP-1 receptors in neurogliaform cells suggesting that endogenous incretins and therapeutic GLP-1 receptor agonists might have effects on these neurons similar to that of pancreatic beta cells. We suggest that novel therapeutic strategies might include modulation of neural insulin production in the brain by GLP-1 agonists for counteracting diabetes, obesity and neurodegenerative diseases. Recent experiments in which lost pancreatic beta cells were replaced by autologous transplants of insulin-producing neural progenitor cells signal the immense therapeutic potential of this approach for diabetes

The changes of the purple coneflower’s (Echinacea purpurea L.) herb and radix drug yield under different fertilization conditions

In this research, the purple coneflower’s (Echinacea purpurea L.) nutrient requirement was examined under different fertilization conditions in a small plot experiment. We measured the medicinal plant’s raw and dry herb and root drug mass and drying loss under different fertilization settings and meteorological factors. From the drug’s raw and dry mass perspective, based on the results, in our opinion, the control setting exceeded all nutrient settings’ results in 2016. In 2017 and 2018, the N75P100K150 nutrient setting has the biggest herb yield. As for the root yield, it was also the N75P100K150 setting which produced the biggest yield. The Pearson's correlation test was performed to investigate the connection between the quantity of the raw, the dried herbs, the different nutrient settings and meteorological factors

Dendrimer pszeudofázisok fizikai kémiai tanulmányozása: dendrimerek módosítása, oldategyensúlyainak, szerkezetének és dinamikájának vizsgálata = Physico-chemical study of dendrimer pseudo phases: functionalization, solution structure, dynamics and equilibria

Tanulmányoztuk a poli-amidoamin (PAMAM) dendrimerek oldatbeli tulajdonságait elsősorban NMR módszerekkel. Diffúzió vizsgálatokkal megállapítottuk, hogy az 5. generációsok merev gömb alakú kolloidként viselkednek vizes oldatban , valamint erősen hidratáltak. Megállapítottuk, hogy az ötödik generációs dendrimerekben mintegy 4000 vízmolekula van kötve. Bebizonyítottuk, hogy a végcsoportok belső donroatomokkal hidrogénhidakat képezhetnek. Az 5. generációs dendrimerek a foszfát és vanadát ionokat reverzíbilisen kötik, valószínüleg a tercier nitrogéneken keresztül. Ez az analitikai tulajdonságokat nem befolyásolják, de lényegesen hathat gyógyszerszállító kpességeire. Meghatároztuk, hogy egy 5. generációs denrimer mintegy 80 réziont köt meg, és a koordináció módja igen változatos. E makromolekulák igen jó modelljei a nanoméretű katalizátoroknak. | We have studied the structure and dynamics of poly(-amidoamine) dendrimers (PAMAM) in aqueous solutions in different NMR techniques. From diffusion studies we concluded that dendrimers of generation 5 behaved as hard sphere colloids. The macromolecules are strongly hydrated we have determined experimentally the hydration numbers as 4000 water molecules per a dendrimer molecule. We have proven the backfolding of the end-groups towards to inside functional groups. The dendrimers of generation 5 bind phoshphate and vanadate in equilibrium probably through tertiary nitrogen donor atoms. The coordination of phosphate does not disturb the analytical behaviors, but may strongly affect the capability of drug delivery. We determined that one PAMAM dendrimer of generation 5 binds 80 copper ions and showed that a wide variety of coordination modes occured. These macromlecules are goof models for nano catalysis

The marigold (Calendula officinalis L.) drug essential oil agents change under different fertilization settings in small plot trial

During our research we investigated the marigold's (Calendula officinalis L.) nutrient requirements with different fertilization setting in small-plot trial. We measured SPME (Solid phase microextraction) and GC-MS (gas chromatograph-mass spectrometer) we examined the effects of the different fertilization settings for the herb's main active ingredients of essential oil's percentage. Based on the results, it was concluded, the essential oil agents' percentage breakdowns significantly depending on the cropping technologies. Besides that it is possible, based on Pearson's correlation test the marigold essential oil agents relationship can also be a major factor

A növénytermesztési tér (talaj-növény) anyagforgalmának interaktív vizsgálata a minőségi búza előállítása céljából = Interactive study of material circulation in agronomy space (soil-plant) for the production of quality wheat

A tartamkísérleti eredményeink azt bizonyították, hogy a növénytermesztési tér (talaj-növény) anyagforgalma (tápanyag- és vízháztartása) jelentősen befolyásolta a földfeletti fitomassza tömeget, a LAI-t, ezeken keresztül pedig az őszi búza termésmennyiségét és minőségét. A nedves sikértartalmat és a valorigráfos értékszámot az évjárat, a fajta és a trágyázás jelentősen, a vetésváltás és növényvédelem mérsékelt mértékben befolyásolta. A búzafajták termésmennyiség szempontjából optimális műtrágya adagját (N60-90+PK) meghaladta a minőség szempontjából optimális műtrágya dózist (N120-150+PK). | The results of our long-term experiments proved, that the materials flows of crop husbandry site (soil-plant) deeply modified the surface dry matter production, the LAI, the yields and the baking quality parameters of winter wheat varieties. The wet gluten content and farinograph index were highly modified by cropyear, genotype and fertilization, and the effects of forecrops and crop protection technology on them were moderate. The optimum fertilizer doses for yields were moderated (N60-90+PK) comparing with the optimum doses for baking quality (N120-150+PK)

Over-representation of the G12S polymorphism of the SDHD gene in patients with MEN2A syndrome

OBJECTIVE: To evaluate whether germline variants of the succinate dehydrogenase genes might be phenotypic modifiers in patients with multiple endocrine neoplasia type 2. Mutations of genes encoding subunits of the succinate dehydrogenase are associated with hereditary paraganglioma/pheochromocytoma syndrome. Pheochromocytoma is one of the main manifestations of multiple endocrine neoplasia type 2 caused by germline mutation of the rearranged during transfection proto-oncogene. METHODS: Polymorphisms of the succinate dehydrogenase genes were analyzed in 77 rearranged during transfection mutation carriers, 47 patients with sporadic medullary thyroid cancer, 48 patients with sporadic Pheo, and 100 healthy individuals. Exons 10-16 of the rearranged during transfection proto-oncogene were analyzed by direct DNA sequencing, and all exons of the von Hippel-Lindau, succinate dehydrogenase B, and succinate dehydrogenase subunit D genes were tested by direct DNA sequencing and multiple ligation probe analysis. The G12S polymorphism of the succinate dehydrogenase subunit D gene was determined by restriction fragment length polymorphism. RESULTS: Of the 77 rearranged during transfection mutation carriers, 55 from 16 families had multiple endocrine neoplasia type 2A, three from three families had multiple endocrine neoplasia type 2B, and 19 from two families had familial medullary thyroid carcinoma. Eight of 55 (14.5%) patients with multiple endocrine neoplasia type 2A had this variant whereas it was absent in multiple endocrine neoplasia type 2B, familial medullary thyroid carcinoma, sporadic medullary thyroid carcinoma, and sporadic pheochromocytoma groups, and its prevalence in controls was 1% (p<0.002 multiple endocrine neoplasia type 2A versus controls). No associations between G12S and age of manifestation, incidence of pheochromocytoma or hyperparathyroidism, or level of serum calcitonin were observed. CONCLUSION: The high prevalence of the G12S variant in patients with multiple endocrine neoplasia type 2A raises questions about its role as a genetic modifier, but this proposal remains to be established

A növényi produkciót befolyásoló talajfizikai, vízgazdálkodási, tápanyaggazdálkodási tulajdonságok interaktív vizsgálata = Interactive examination of soil physical, water balance, nutrient management characteristics determining plant production

A kutatásba három növényfajt vontunk be a kutatási tervben foglaltaknak megfelelően, az őszi búzát, tritikálét, (C3-as) és a kukoricát (C4-es). Őszi búzából három fajtát, kukoricából szintén három, eltérő tenyészidejű hibridet, tritikáléból egy fajtát vizsgáltunk. A kutatási tervben meghatározott méréseket sikerült elvégeznünk, az adatok feldogozása megtörtént, az eddigi eredményeket részben publikáltuk is. Az őszi búza vizsgálatok azt mutatják, hogy szignifikáns különbségek vannak a fajták között minden mérési időpontban. Szoros korrelációt lehetett kimutatni a kalászoláskori fotoszintézis intenzitás és a termés között a vizsgált őszi búza fajták esetében. A kedvező vízellátottság következtében nem volt megfigyelhető a 2003-ban jellemző depresszió a nagyobb N dózisok miatt, a fotoszintézis intenzitása minden időpontban az N120P90K106 kezelésben volt a legmagasabb A kukoricában végzett mérések elemzése során megállapítható, hogy az első mérési időpontban volt a legmagasabb a nettó fotoszintézis intenzitása, a tenyészidő során fokozatosan csökkent mindegyik kukoricahibrid esetében. A különböző műtrágyázási szintek szignifikáns eltérést eredményeztek a fotoszintetikus aktivitásban. Az első méréskor a kontroll és a 60 kg N+PK adag között nem volt igazolható a különbség, a többi esetben 5 %-os szinten szignifikáns eltérés volt. A három mérési időpont átlagában a legmagasabb értéket a középső, 120 kg N+PK, műtrágyaadagnál mértük. | The aim of our work is to add some information about the yield forming procedure of winter wheat. Taking leaf gas exchange measurements not in a laboratory but in the field has great significance. We measured the net photosynthesis of three winter wheat, maize varieties and one triticale variety in a field trial on the nutrient supply. evaluating the survey data In winter wheat it is concluded that there were significant differences between net photosynthetic rate of varieties in all of years. However there were no significant deviations in all cases. We made the pair-wise comparison of the varieties in all the four measurements dates. In the case of some varieties, there were no statistical differences in the net photosynthesis rate. The results of the present study show close significant correlation between yield and net photosynthesis in heading growth stage. By the help of these connections we can get closer to understanding of the yield-forming processes of winter wheat In maize after data processing we found that there are significant differences on P=5% level in the net photosynthesis, the stomatal conductance and the transpiration results between the nutrient levels in all the season. The differences in the intercellular CO2 concentration are not significant in every case, but the data measured in the N0P0K0 blocks are significantly lower than those in the other levels. The varied nutrient supply caused differences in the net photosynthetic rate