Morus alba’ nın meyve ve yaprak ekstrelerinin antioksidan kapasitelerinin belirlenmesi

Bu çalışmada Elazığ’dan toplanan Morus alba’ nın antioksidan ve antiradikal kapasitesi incelendi. Bitkinin yaprakları ve meyveleri gölgede kurutularak ayrı ayrı su ve etanol ekstreleri hazırlandı. Ekstreler soksilet cihazı ile yapıldı. Bu ekstrelerin antioksidan ve antiradikal testleri, toplam antioksidan kapasite, indirgeme gücü kapasitesi, metal şelatlama aktivitesi, DPPH• serbest radikali giderme aktivitesi, ABTS•+ radikali giderme aktivitesi, süperoksit anyon radikalleri giderme aktivitesi, H2O2 giderme aktivitesi ve FRAP testi gibi farklı antioksidan metotlar ve ek olarak toplam fenolik bileşik miktarı tayini kullanılarak farklı konsantrasyonlarda ayrı ayrı belirlendi. Elde edilen sonuçlara bakıldığında dutun yapraklarının ve meyvelerinin iyi bir serbest radikal gidericisi olduğu ve doğal bir antioksidan olarak kullanılabileceği bulundu.In this study Morus alba investigated the antioxidant and antiradical capacity that it was collected from Elazıg. Leaves and fruits of plants dried in shade, water and ethanol extracts were prepared separately . The extracts were made with Soxhlet apparatus. These extracts, antioxidant and antiradical tests, different antioxidant methods such as total antioxidant capacity, reducing power capacity, metal chelating activity, DPPH• free radical scavenging activity, ABTS•+ radical scavenging activity, superoxide anion radicals scavenging activity, H2O2scavenging activity and FRAP test and in addition to by using the amount of the total phenolic compounds determined separately at different concentrations. Looking at the results obtained, leaves and the fruits of mulberry found as a good free radical scavenging and was used as a natural antioxidant

Effects of Rubus discolor flower extract on the fatty acid composition in hydrogen peroxide administered Wistar rats

The aim of this research is to examine possible protective effects of Rubus discolor (RD) flower extracts on the fatty acid contents of some tissues, which hydrogen peroxide (HP) administered Wistar rats. In present study, Wistar rats were randomly divided into four groups: 1. Control (C), 2. Hydrogen Peroxide (HP), 3. Rubus discolor (RD), 4. Rubus discolor + Hydrogen Peroxide (RD+HP). In tissues, fatty acid content analyses were performed by gas chromatography. According to our results, while fatty acid levels were barely affected in the heart, muscle, brain and spleen tissues of HP group, but these levels were affected in the serum, liver, kidney and lung tissues of the same group when compared to the control group. The fatty acid contents were changed in all tissues of RD and RD+HP groups when compared to control group. Our results confirm that RD and HP treatment have affected the amount of important fatty acids, which substrates in fatty acids metabolism of Wistar rats. In also, this study is first report about the effects of R. discolor flower extract on the fatty acid composition.Bu çalışmanın amacı hidrojen peroksit (HP) uygulanmış Wistar sıçanların bazı dokularının yağ asidi içeriği üzerinde Rubus discolor (RD) çiçek ekstresinin olası koruyucu etkilerini incelemektir. Sunulan çalışmada, Wistar sıçanlar rastgele 4 ayrı gruba ayrıldı: 1. Kontrol (C), 2. Hidrojen Peroksit (HP), 3. Rubus discolor (RD), 4. Rubus discolor + Hidrojen Peroksit (RD+HP). Dokulardaki yağ asidi içeriği gaz kromatografisi cihazıyla analiz edildi. Sonuçlarımıza göre, kontrol grubuyla karşılaştırıldığı zaman, HP grubunun kalp, kas, beyin ve dalak dokusunda yağ asidi seviyeleri hemen hemen hiç etkilenmezken, aynı grubun serum, karaciğer, böbrek ve akciğer dokularında yağ asitleri seviyeleri etkilenmiştir. RD ve RD+HP gruplarının bütün dokularında yağ asidi içeriği kontrol grubuna göre değişmiştir. Sonuçlarımız göstermiştir ki RD ve HP uygulaması, Wistar sıçanların yağ asidi metabolizmasında substrat olan bazı önemli yağ asitlerinin miktarını etkilemiştir. Ayrıca bu çalışma R. discolor çiçek ekstresinin yağ asidi içeriği üzerindeki etkileri hakkında ilk rapordur

Military jet pilots have higher p-wave dispersions compared to the transport aircraft aircrew

Objectives: For the purpose of flight safety military aircrew must be healthy. P-wave dispersion (PWD) is the p-wave length difference in an electrocardiographic (ECG) examination and represents the risk of developing atrial fibrillation. In the study we aimed at investigating PWD in healthy military aircrew who reported for periodical examinations. Material and Methods: Seventy-five asymptomatic military aircrew were enrolled in the study. All the subjects underwent physical, radiologic and biochemical examinations, and a 12-lead electrocardiography. P-wave dispersions were calculated. Results: The mean age of the study participants was 36.15±8.97 years and the mean p-wave duration was 100.8±12 ms in the whole group. Forty-seven subjects were non-pilot aircrew, and 28 were pilots. Thirteen study subjects were serving in jets, 49 in helicopters, and 13 were transport aircraft pilots. Thirty-six of the helicopter and 11 of the transport aircraft aircrew were non-pilot aircrew. P-wave dispersion was the lowest in the transport aircraft aircrew, and the highest in jet pilots. P-wave dispersions were similar in the pilots and non-pilot aircrew. Twenty-three study subjects were overweight, 19 had thyroiditis, 26 had hepatosteatosis, 4 had hyperbilirubinemia, 2 had hypertension, and 5 had hyperlipidemia. The PWD was significantly associated with thyroid-stimulating hormone (TSH) levels. Serum uric acid levels were associated with p-wave durations. Serum TSH levels were the most important predictor of PWD. Conclusions: When TSH levels were associated with PWD, uric acid levels were associated with p-wave duration in the military aircrew. The jet pilots had higher PWDs. These findings reveal that military jet pilots may have a higher risk of developing atrial fibrillation, and PWD should be recorded during periodical examinations

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Download citation Share Download full-text PDF The impact of perceived organizational support on work–family conflict: Does role overload have a mediating role?

The present cross-sectional study aims to investigate (1) the direct effects of perceived organizational support and role overload on work–family conflict and (2) the mediating role of role overload in the relationship between perceived organizational support and work–family conflict using a Turkish sample. The hypotheses were tested with a sample of 344 employees from small and medium-sized enterprises in Turkey. The results demonstrated that perceived organizational support was negatively related to both family to work conflict and work to family conflict of the employees. Role overload was also positively related to both family to work conflict and work to family conflict. In addition, the results indicated that role overload did not have a mediating role between perceived organizational support and work–family conflict