Radiative Decay Width Measurements of Neutral Kaon Excitations Using the Primakoff Effect

We produce a sample consisting of 147 candidate events, with minimal backgrounds, of the mixed axial vector pair K1(1270)-K1(1400) by exciting Kl's in the Coulomb field of lead and report the first measurements of the radiative widths Gamma_r(K1(1400)) = 280.8+-23.2(stat)+-40.4(syst) keV and Gamma_r(K1(1270)) = 73.2+- 6.1(stat)+-28.3(syst) keV. We also place 90% CL upper limits Gamma_r(K*(1410)) < 52.9 keV for the vector state and Gamma_r(K2*(1430)) < 5.4 keV for the tensor state. These measurements allow for significant tests of quark-model predictions of radiative widths for the low-lying vector mesons.Comment: PRL-size article, 4 figure

Some Wolstenholme type congruences

In this paper we give an extension and another proof of the following Wolstenholme's type curious congruence established in 2008 by J. Zhao. Let s and l be two positive integers and let p be a prime such that p ls + 3. Then H(fsgl; p1) S(fsgl; p1) 8>>< >>: s(ls + 1)p2 2(ls + 2) Bpls2 (mod p3) if 2 - ls (1)l1 sp ls + 1 Bpls1 (mod p2) if 2 j ls: APs an application, for given prime p 5, we obtain explicit formulae for the sum 1 k1< <kl p1 1=(k1 kl) (mod p3) if k 2 f1; 3; : : : ; p 2g, and for the sum P 1 k1< <kl p1 1=(k1 kl) (mod p2) if k 2 f2; 4; : : : ; p 3

VLBI Imagings of Kilo-parsec Knot in 3C 380

We investigate observational properties of a kilo-parsec scale knot in radio-loud quasar 3C 380 by using two epoch archival data obtained by Very Long Baseline Interferometry (VLBI) at 5 GHz on 1998 July and 2001 April. We succeed in obtaining the highest spatial resolution image of the bright knot K1 located at 732 milliarcseconds, or more than 20 kpc de-projected, downstream from the nucleus three times better than previously obtained highest resolution image by Papageorgiou et al. (2006). Our images reveal, with new clarity, "inverted bow-shock" structure in K1 facing the nucleus and its morphology resembles a conical shock wave. By comparing the two epoch images directly, we explore the kinematics of K1 and obtain the upper limit of apparent velocity, 0.25 mas/yr or 9.8 c of K1 for the first time. The upper limit of apparent velocity is marginally smaller than superluminal motions seen in the core region. Further new epoch VLBI observations are necessary to measure the proper motion at K1.Comment: 15 pages, 4 figures, accepted for publication in PAS

Experimental Validation of the Predicted Binding Site of Escherichia coli K1 Outer Membrane Protein A to Human Brain Microvascular Endothelial Cells: Identification of Critical Mutations That Prevent E. coli Meningitis

Escherichia coli K1, the most common cause of meningitis in neonates, has been shown to interact with GlcNAc1–4GlcNAc epitopes of Ecgp96 on human brain microvascular endothelial cells (HBMECs) via OmpA (outer membrane protein A). However, the precise domains of extracellular loops of OmpA interacting with the chitobiose epitopes have not been elucidated. We report the loop-barrel model of these OmpA interactions with the carbohydrate moieties of Ecgp96 predicted from molecular modeling. To test this model experimentally, we generated E. coli K1 strains expressing OmpA with mutations of residues predicted to be critical for interaction with the HBMEC and tested E. coli invasion efficiency. For these same mutations, we predicted the interaction free energies (including explicit calculation of the entropy) from molecular dynamics (MD), finding excellent correlation (R^2 = 90%) with experimental invasion efficiency. Particularly important is that mutating specific residues in loops 1, 2, and 4 to alanines resulted in significant inhibition of E. coli K1 invasion in HBMECs, which is consistent with the complete lack of binding found in the MD simulations for these two cases. These studies suggest that inhibition of the interactions of these residues of Loop 1, 2, and 4 with Ecgp96 could provide a therapeutic strategy to prevent neonatal meningitis due to E. coli K1

Multiple human herpesvirus-8 infection

In Malawian patients with Kaposi sarcoma (KS) and their relatives, we investigated nucleotide-sequence variation in human herpesvirus-8 (HHV-8) subgenomic DNA, amplified from oral and blood samples by use of polymerase chain reaction. Twenty-four people had amplifiable HHV-8 DNA in >1 sample; 9 (38%) were seropositive for human immunodeficiency virus type 1, 21 (88%) were anti-HHV-8-seropositive, and 7 (29%) had KS. Sequence variation was sought in 3 loci of the HHV-8 genome: the internal repeat domain of open-reading frame (ORF) 73, the KS330 segment of ORF 26, and variable region 1 of ORF K1. Significant intraperson/intersample and intrasample sequence polymorphisms were observed in 14 people (60%). For 3 patients with KS, intraperson genotypic differences, arising from nucleotide sequence variations in ORFs 26 and K1, were found in blood and oral samples. For 2 other patients with KS and for 9 people without KS, intraperson genotypic and subgenotypic differences, originating predominantly from ORF K1, were found in oral samples; for the 2 patients with KS and for 4 individuals without KS, intrasample carriage of distinct ORF K1 sequences also were discernible. Our findings imply HHV-8 superinfection

Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity

Tetranectin is a plasminogen kringle 4 domain-binding protein present in plasma and various tissue locations. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis. A possible mechanism through which tetranectin could influence cancer progression is by altering activities of plasminogen or the plasminogen fragment, angiostatin. Tetranectin was found to bind to the kringle 1-4 form of angiostatin (AST(K1-4)). In addition, tetranectin inhibited binding of plasminogen or AST(K1-4) to extracellular matrix (ECM) deposited by endothelial cells. Finally, tetranectin partially counteracted the ability of AST(K1-4) to inhibit proliferation of endothelial cells. This latter effect of tetranectin was specific for AST(K1-4) since it did not counteract the antiproliferative activities of the kringle 1-3 form of angiostatin (AST(K1-3)) or endostatin. These findings suggest that tetranectin may modulate angiogenesis through interactions with AST

Entire choosability of near-outerplane graphs

It is proved that if G is a plane embedding of a K4-minor-free graph with maximum degree Δ, then G is entirely 7-choosable if Δ≤4 and G is entirely (Δ+ 2)-choosable if Δ≥ 5; that is, if every vertex, edge and face of G is given a list of max{7,Δ+2} colours, then every element can be given a colour from its list such that no two adjacent or incident elements are given the same colour. It is proved also that this result holds if G is a plane embedding of a K2,3-minor-free graph or a (K2 + (K1 U K2))-minor-free graph. As a special case this proves that the Entire Colouring Conjecture, that a plane graph is entirely (Δ + 4)-colourable, holds if G is a plane embedding of a K4-minor-free graph, a K2,3-minor-free graph or a (K2 + (K1 U K2))-minor-free graph