Inventario y aprecio de las antigüedades y piedras labradas de D. Francisco de Bruna y Ahumada

Letras varias del siglo 19. Los fol. 1 y 2 están escritos por Antonio Delgado, hijo de uno de los tasadores del Monetario, en Madrid a 28 de octubre de 1848. En ellos se dan las noticias que constan en los títulos y otras sobre el monetarioEncuadernación: Holandesa. Rotul.: Monetario de Bruna | Marcas procedencia: Biblioteca de la Universidad de Sevilla (sello moderno). Donacion Francisco Caballero Infante (en 1897)A 331/22

Robust control of an evaporator through algebraic Riccati equations and d-k iteration

Evaporation is a process that is widely used in the chemical industry and aims to concentrate a solution consisting of a non-volatile solute and a volatile solvent. In this paper the design of robust control systems for a simple effect evaporation system is presented. Two controllers were designed, the first was based on the Algebraic Riccati Equations (ARE) solutions technique and the second was derived from the D-K iteration method. To show the potentiality of the control system proposed, we present the results of some tests carried out in simulation

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.

Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and common variants on BP, we conducted genetic analyses in 26 Colombia and Costa Rica pedigrees ascertained for bipolar disorder 1 (BP1), the most severe and heritable form of BP. In these pedigrees, we performed microarray SNP genotyping of 838 individuals and high-coverage whole-genome sequencing of 449 individuals. We compared polygenic risk scores (PRS), estimated using the latest BP1 genome-wide association study (GWAS) summary statistics, between BP1 individuals and related controls. We also evaluated whether BP1 individuals had a higher burden of rare deleterious single-nucleotide variants (SNVs) and rare copy number variants (CNVs) in a set of genes related to BP1. We found that compared with unaffected relatives, BP1 individuals had higher PRS estimated from BP1 GWAS statistics (P = 0.001 ~ 0.007) and displayed modest increase in burdens of rare deleterious SNVs (P = 0.047) and rare CNVs (P = 0.002 ~ 0.033) in genes related to BP1. We did not observe rare variants segregating in the pedigrees. These results suggest that small-to-moderate effect rare and common variants are more likely to contribute to BP1 risk in these extended pedigrees than a few large-effect rare variants

Effectiveness of new tools to define an up-to-date patient safety risk map: A primary care study protocol

Background: Reducing incidents related to health care interventions to improve patient safety is a health policy priority. To strengthen a culture of safety, reporting incidents is essential. This study aims to define a patient safety risk map using the description and analysis of incidents within a primary care region with a prior patient safety improvement strategy organisationally developed and promoted. Methods: The study will be conducted in two phases: (1) a cross-sectional descriptive observational study to describe reported incidents; and (2) a quasi-experimental study to compare reported incidents. The study will take place in the Camp de Tarragona Primary Care Management (Catalan Institute of Health). In Phase 1, all reactive notifications collected within one year (2018) will be analysed; during Phase 2, all proactive notifications of the second and third weeks of June 2019 will be analysed. Adverse events will also be assessed. Phases 1 and 2 will use a digital platform and the proactive tool proSP to notify and analyse incidents related to patient safety. Expected Results: To obtain an up-to-date, primary care patient safety risk map to prioritise strategies that result in safer practices. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Elementos para un enfoque de la competitividad en el sector agropecuario

Colección Documentos. Serie Competitividad (IICA)no. 2.En la agricultura de América Latina nunca se planteó a fondo el problema de la competitividad sectorial o cuando ello se hizo, fue de manera distorsionada, condicionada como objetivo de largo plazo a incentivos de corto o mediano plazos que acabaron aplazando permanentemente decisiones que requerían de un largo período de maduración. El descuido frente a las necesidades estratégicas de la competitividad es explicable en parte por el exitoso aprovechamiento, en el pasado reciente, de algunos cambios tecnológicos, por la explotación igualmente exitosa de algunos auges del mercado o por procesos de inversión y apoyo públicos (irrigación, tecnología, insumos subsidiados), los que junto a aprovechamiento de las condicionales naturales, permitieron excepcionales aumentos de productividad. (MV

Una política comercial de transición

Serie Competitividad (IICA) no. 1.Este documento su propósito se reduce a establecer los elementos centrales de la discusión sobre las intervenciones gubernamentales en los precios internos o en los precios de fronteras, y a contribuir a las reflexiones en orden a sustituir los tradicionales esquemas de apoyo de precios por otros más compatibles con las nuevas realidades de la economía internacional: esto implica ampliar el margen de maniobra para diseñar instrumentos, precisar indicaciones sobre los arreglos institucionales necesarios para ello y alertar sobre aquellas limitaciones políticas, operacionales e institucionales que pudieran preverse para enfrentar la transición, y sobre las cuales debieran realizarse esfuerzos especiales, con el fin de asegurar una conducción exitosa de las políticas comerciales en el futuro. La primera sección describe la manera sumaria las nuevas circunstancias externas que delimitan las intervenciones de política comercial del país y en las cuales descansó. La segunda sección repasa las implicaciones de las reformas de política comercial tanto en el ámbito productivo como en el de las tensiones políticas que surgen de esas reformas más precisamente de la remoción de las intervenciones en precios examinados desde esa perspectiva los problemas de gradualidad y las condiciones políticas de supervivencia de las reformas. La tercera sección examina la experiencia internacional de reformas comerciales en las últimas décadas, con el propósito de relevar cómo surgen las presiones a la contrarreforma, qué papel tienen las condiciones económicas y política inmediatamente anteriores a la consolidación de los resultados de la reforma y los requisitos que deben satisfacerse para asegurar la viabilidad y la no reversibilidad de las políticas de apertura comercial. La cuarta sección aborda la discusión sobre costos y beneficios de las reformas en el corto y largo plazos, el papel de la inercia (generada por un largo período de protección), de la proclividad a la búsqueda de rentas, de la incertidumbre y del equilibrio político sobre la demanda de protección que normalmente se ampara en una falta de comprensión de las dificultades de corto plazo que resultad del desmonte de las intervenciones, finalmente se proponen algunas consideraciones sobre aquellas áreas de política que deben recibir la mayor atención para facilitar la transición. (MV

Polymorphisms in RYBP and AOAH Genes Are Associated with Chronic Rhinosinusitis in a Chinese Population: A Replication Study

BACKGROUND: The development of CRS is believed to be the result of combined interactions between the genetic background of the affected subject and environmental factors. OBJECTIVES: To replicate and extend our recent findings from genetic association studies in chronic rhinosinusitis (CRS) performed in a Canadian Caucasian population in a Chinese population. METHODS: In a case-control replication study, DNA samples were obtained from CRS with (n  = 306; CRSwNP) and without (n = 332; CRSsNP) nasal polyps, and controls (n = 315) in a Chinese population. A total of forty-nine single nucleotide polymorphisms (SNPs) selected from previous identified SNPs associated with CRS in Canadian population, and SNPs from the CHB HapMap dataset were individually genotyped. RESULTS: We identified two SNPs respectively in RYBP (rs4532099, p = 2.15E-06, OR = 2.59) and AOAH (rs4504543, p = 0.0001152, OR = 0.58) significantly associated with whole CRS cohort. Subgroup analysis for the presence of nasal polyps (CRSwNP and CRSsNP) displayed significant association in CRSwNP cohorts regarding to one SNP in RYBP (P = 3.24(E)-006, OR = 2.76). Evidence of association in the CRSsNP groups in terms of 2 SNPs (AOAH_rs4504543 and RYBP_rs4532099) was detected as well. Stratifying analysis by gender demonstrated that none of the selected SNPs were associated with CRSwNP as well as CRSsNP. Meanwhile 3 SNPs (IL1A_rs17561, P = 0.005778; IL1A_rs1800587, P = 0.009561; IRAK4_rs4251513, P = 0.03837) were associated with serum total IgE level. CONCLUSIONS: These genes are biologically plausible, with roles in regulation of transcription (RYBP) and inflammatory response (AOAH). The present data suggests the potential common genetic basis in the development of CRS in Chinese and Caucasian population