Characterization of path loss and absorption for a wireless radio frequency link between an in-body endoscopy capsule and a receiver outside the body

Physical-layer characterization is important for design of in-to-out body communication for wireless body area networks (WBANs). This paper numerically investigates the path loss and absorption of an in-to-out body radio frequency (RF) wireless link between an endoscopy capsule and a receiver outside the body using a 3D electromagnetic solver. A spiral antenna in the endoscopy capsule is tuned to operate in the Medical Implant Communication Service (MICS) band at 402 MHz, accounting for the properties of the human body. The influence of misalignment, rotation of the capsule, and three different human models are investigated. Semi-empirical path loss models for various homogeneous tissues and 3D realistic human body models are provided for manufacturers to evaluate the performance of in-body to out-body WBAN systems. The specific absorption rate (SAR) in homogeneous and heterogeneous body models is characterized and compliance is investigated

Design and Implementation of a Hybrid Wireless Power and Communication System for Medical Implants

Data collection and analysis from multiple implant nodes in humans can provide targeted medicine and treatment strategies that can prevent many chronic diseases. This data can be collected for a long time and processed using artificial intelligence (AI) techniques in a medical network for early detection and prevention of diseases. Additionally, machine learning (ML) algorithms can be applied for the analysis of big data for health monitoring of the population. Wireless powering, sensing, and communication are essential parts of future wireless implants that aim to achieve the aforementioned goals. In this paper, we present the technical development of a wireless implant that is powered by radio frequency (RF) at 401 MHz, with the sensor data being communicated to an on-body reader. The implant communication is based on two simultaneous wireless links: RF backscatter for implant-to-on-body communication and a galvanic link for intra-body implant-to-implant connectivity. It is demonstrated that RF powering, using the proposed compact antennas, can provide an efficient and integrable system for powering up to an 8 cm depth inside body tissues. Furthermore, the same antennas are utilized for backscatter and galvanic communication

An Ultra-Wideband Conformal Meandered Loop Antenna for Wireless Capsule Endoscopy

This work presents an ultra-wideband conformal meandered loop antenna for wireless capsule endoscopy applications. The proposed antenna surrounds the outer wall of a capsule, so that the inner space can be used by a battery and other electrical and optical components. Fabricated on a flexible substrate, the antenna has a diameter of 10 mm and a height of 14 mm when wrapped around a cylindrical capsule. The antenna achieves an ultra-wide impedance bandwidth of 200 MHz–2.05 GHz (164% of the fractional bandwidth), which provides sufficient coverage for the medical implant communication service, MedRadio, and industrial-scientific-medical (ISM) bands. This antenna also ensures robustness to the detuning effect, which could be caused by the inner components of the capsule and the outer environment variations. The omnidirectional radiation pattern of the antenna is verified by simulations and measurements, and its maximum gain is −31.5 dBi. The fabricated antenna is successfully tested in an over-the-air wireless communication link, proving that the antenna can be instrumental in wireless capsule endoscopy applications

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

Video capsule endoscopy (VCE) is now a clinically accepted diagnostic modality in which miniaturized technology, an on-board power supply and wireless telemetry stand as technological foundations for other capsule endoscopy (CE) devices. However, VCE does not provide therapeutic functionality, and research towards therapeutic CE (TCE) has been limited. In this paper, a route towards viable TCE is proposed, based on multiple CE devices including important acoustic sensing and drug delivery components. In this approach, an initial multimodal diagnostic device with high-frequency quantitative microultrasound that complements video imaging allows surface and subsurface visualization and computer-assisted diagnosis. Using focused ultrasound (US) to mark sites of pathology with exogenous fluorescent agents permits follow-up with another device to provide therapy. This is based on an US-mediated targeted drug delivery system with fluorescence imaging guidance. An additional device may then be utilized for treatment verification and monitoring, exploiting the minimally invasive nature of CE. While such a theranostic patient pathway for gastrointestinal treatment is presently incomplete, the description in this paper of previous research and work under way to realize further components for the proposed pathway suggests it is feasible and provides a framework around which to structure further work

Ultra-wide-angle Wireless Endoscope with a Backend-camera-controller Architecture

This paper presents a wireless endoscope with an ultra-wide FOV (Field of View) of 130° and HD resolution (1280x720 pixels). The proposed endoscope consists of a camera head, cable, camera controller, and wireless handle. The lens module with a 150° degrees AOV (Angle of View) is achieved using the plastic injection-molding process to reduce manufacturing costs. A serial CMOS image sensor using the MIPI (Mobile Industry Processor Interface) CSI-2 (Camera Serial Interface-2) interface physically separates the camera processor from the camera head. The camera head and the cable have a compact structure due to the BCC (Backend-Camera-Controller) architecture. The size of the camera head and the camera controller is 8x8x26 mm and 7x55 mm, respectively. The wireless handle supports a UWB (Ultra-Wide-Band) or a Wi-Fi communication to transmit video data. The UWB link supports a maximum data transfer rate of ~37 Mbps to transmit video data with a resolution of 1280x720 pixels at a frame rate of 30 fps in the MJPEG (Motion JPEG) format. Although the Wi-Fi link provides a lower data transfer rate (~8 Mbps Max.), it has the advantage of flexible interoperability with various mobile devices. The latency of the UWB link is measured to be ~0.1 sec. The Wi-Fi link has a larger latency (~0.5 sec) due to its lower data transfer rate. The proposed endoscope demonstrates the feasibility of a high-performance yet low-cost wireless endoscope using the BCC architecture. To the best of the author’s knowledge, the proposed endoscope has the largest FOV among all presently existing wireless endoscopes.Ultra-wide-angle Wireless Endoscope with a Backend-camera-controller Architectur

의료용 인체 삽입물을 위한 무선 저전력 송수신기에 관한 연구

학위논문 (박사)-- 서울대학교 대학원 : 전기·컴퓨터공학부, 2016. 2. 남상욱.This thesis presents the wireless transceiver for medical implant application. The high propagation loss in human body which has high relative permittivity and conductive makes the implantable device be required for high sensitivity. Moreover, the device should have low power consumption to use for wireless implant medical application due to a restricted battery life. Also, this problem should be solved for on-body device considering integration with mobile device in the future. Simultaneously, the specific medical application such as epiretinal prosthesis, multi-channel electroencephalogram sensor demand high-data rate. Therefore, it is a main challenge that enhancing the devices power consumption and data-rate for implantable medical application. In order to enhance the performance of the device, several techniques are proposed in implantable human body transceivers. Firstly, the propagation loss in human-body is calculated for determine the frequency for medical implant application. The frequency bands allocated by FCC or MICS are too narrow and high lossy bands in human-body. For this reason, the optimum frequency for Implantable medical device is found by using Frisss formula and the link budget is calculated for capsule endoscopy system. The optimum frequency is verified through image recovery experiment in liquid human phantom and pig by using designed capsule endoscopy system. Secondly, the Super-Regenerative Receiver (SRR) with Digital Self-Quenching Loop (DSQL) is proposed for low power consumption. The proposed DSQL replaces the envelope detector used in a conventional SRR and minimizes power consumption by generating a self-quench signal digitally for a super-regenerative oscillator. The measurement results are given to show the performance of the proposed receiver. Thirdly, the RF Current Reused and Current Combining (CRCC) Power Amplifier (PA) is proposed for low power and high-speed transmitter. Normally, the PA having low output power has a feasibility issue that an optimum impedance of PA is too high to match with antenna impedance. For this reason, obtaining the maximum efficiency of PA is difficult for conventional structure. Moreover, conventional PAs output bandwidth is to be narrow due to high impedance transform ratio between PAs output and antennas input impedances. The CRCC structure solves this issue by decreasing the impedance transform ratio. The transmitter with CRCC PA is designed and verified through the measurement.Chapter 1. Introduction 1 1.1. WBAN (Wireless Body Area Network) 1 1.2. Challenges in Designing Transceiver for Medical Implant Application 7 Chapter 2. Propagation Loss in Human Body 10 2.1. Introduction 10 2.2. Far field approximation in human-body 13 2.3. Calculation of propagation loss in human-body 15 2.3.1. Frisss formula 15 2.3.2. Efficiency of transmitting antenna in human-body 17 2.4. Calculation of propagation loss in human-body and conclusion 19 Chapter 3. A Design of Transceiver for Capsule Endoscopy Application 21 3.1. Introduction 21 3.2. System Link Budget Calculation 24 3.3. Implementation 26 3.3.1. Transmitter with class B amplifier 26 3.3.2. Super-heterodyne receiver with AGC 28 3.3.3. Measurement results 30 3.4. Image recovery experiment 35 3.4.1. Integration of capsule endoscopy 35 3.4.2. Image recovery in the liquid human phantom 38 3.4.3. Image recovery in a pigs stomach and large intestine 40 3.5. Conclusion 41 Chapter 4. Super-Regenerative Receiver with Digitally Self-Quenching Loop 42 4.1. Introduction 42 4.1.1. Selection of receivers architecture for implantable medical device 44 4.1.2. Previous study of super-regenerative receiver 50 4.2. Main idea of proposed super-regenerative receiver 51 4.3. Description of proposed receiver 53 4.3.1. Digital self-quenching loop 55 4.3.2. Low noise amplifier and super-regenerative oscillator 57 4.3.3. Active RC filter for low power consumption 59 4.4. Experimental results 63 4.5. Summary and conclusion 69 Chapter 5. A Transmitter with Current-Reused and Current-Combining PA 71 5.1. Introduction 71 5.1.1. Previous study of OOK transmitter 72 5.2. Main idea of proposed transmitter 73 5.3. Description of proposed transmitter 79 5.3.1. Current-combining and current-reused PA 79 5.3.2. Ring oscillator with driving buffer 83 5.4. Experimental Results 85 5.5. Summary and conclusion 93 Chapter 6. Conclusion 95 Chapter 7. Appendix 97 7.1. Output spectrum of OOK signal 97 7.2. Theoretical BER of OOK comunication 99 Bibliography 101 초 록 109Docto

Capsule endoscopy system with novel imaging algorithms

Wireless capsule endoscopy (WCE) is a state-of-the-art technology to receive images of human intestine for medical diagnostics. In WCE, the patient ingests a specially designed electronic capsule which has imaging and wireless transmission capabilities inside it. While the capsule travels through the gastrointestinal (GI) tract, it captures images and sends them wirelessly to an outside data logger unit. The data logger stores the image data and then they are transferred to a personal computer (PC) where the images are reconstructed and displayed for diagnosis. The key design challenge in WCE is to reduce the area and power consumption of the capsule while maintaining acceptable image reconstruction. In this research, the unique properties of WCE images are identified by analyzing hundreds of endoscopic images and video frames, and then these properties are used to develop novel and low complexity compression algorithms tailored for capsule endoscopy. The proposed image compressor consists of a new YEF color space converter, lossless prediction coder, customizable chrominance sub-sampler and an efficient Golomb-Rice encoder. The scheme has both lossy and lossless modes and is further customized to work with two lighting modes – conventional white light imaging (WLI) and emerging narrow band imaging (NBI). The average compression ratio achieved using the proposed lossy compression algorithm is 80.4% for WBI and 79.2% for NBI with high reconstruction quality index for both bands. Two surveys have been conducted which show that the reconstructed images have high acceptability among medical imaging doctors and gastroenterologists. The imaging algorithms have been realized in hardware description language (HDL) and their functionalities have been verified in field programmable gate array (FPGA) board. Later it was implemented in a 0.18 μm complementary metal oxide semiconductor (CMOS) technology and the chip was fabricated. Due to the low complexity of the core compressor, it consumes only 43 µW of power and 0.032 mm2 of area. The compressor is designed to work with commercial low-power image sensor that outputs image pixels in raster scan fashion, eliminating the need of significant input buffer memory. To demonstrate the advantage, a prototype of the complete WCE system including an FPGA based electronic capsule, a microcontroller based data logger unit and a Windows based image reconstruction software have been developed. The capsule contains the proposed low complexity image compressor and can generate both lossy and lossless compressed bit-stream. The capsule prototype also supports both white light imaging (WLI) and narrow band imaging (NBI) imaging modes and communicates with the data logger in full duplex fashion, which enables configuring the image size and imaging mode in real time during the examination. The developed data logger is portable and has a high data rate wireless connectivity including Bluetooth, graphical display for real time image viewing with state-of-the-art touch screen technology. The data are logged in micro SD cards and can be transferred to PC or Smartphone using card reader, USB interface, or Bluetooth wireless link. The workstation software can decompress and show the reconstructed images. The images can be navigated, marked, zoomed and can be played as video. Finally, ex-vivo testing of the WCE system has been done in pig's intestine to validate its performance

Conformal antenna-based wireless telemetry system for capsule endoscopy

Capsule endoscopy for imaging the gastrointestinal tract is an innovative tool for carrying out medical diagnosis and therapy. Additional modalities beyond optical imaging would enhance current capabilities at the expense of denser integration, due to the limited space available within the capsule. We therefore need new designs and technologies to increase the smartness of the capsules for a given volume. This thesis presents the design, manufacture and performance characterisation of a helical antenna placed conformally outside an endoscopic capsule, and the characterisation in-silico, in-vitro and in-vivo of the telemetry system in alive and euthanised pigs. This method does not use the internal volume of the capsule, but does use an extra coating to protect the antenna from the surrounding tissue and maintain biocompatibility for safe use inside the human body. The helical antenna, radiating at 433 MHz with a bandwidth of 20 MHz within a muscle-type tissue, presents a low gain and efficiency, which is typical for implantable and ingestible medical devices. Telemetry capsule prototypes were simulated, manufactured and assembled with the necessary internal electronics, including a commercially available transceiver unit. Thermistors were embedded into each capsule shell, to record any temperature increase in the tissue surrounding the antenna during the experiments. A temperature increase of less than 1°C was detected for the tissue surrounding the antenna. The process of coating the biocompatible insulation layer over the full length of the capsule is described in detail. Data transmission programmes were established to send programmed data packets to an external receiver. The prototypes radiated at different power levels ranging from -10 to 10 dBm, and all capsules demonstrated a satisfactory performance at a data rate of 16 kbps during phantom and in-vivo experiments. Data transmission was achieved with low bit-error rates below 10-5. A low signal strength of only -54 dBm still provided effective data transfer, irrespective of the orientation and location of the capsule, and this successfully demonstrated the feasibility of the system