666 research outputs found

    Preliminary findings on the correlation of saliva pH, buffering capacity, flow rate and consistency in relation to waterpipe tobacco smoking

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    The aim of the present comparative study was to compare some salivary characteristics between exclusive waterpipe smokers (EWPS) and non-smokers. 72 males (36 EWPS) were recruited. The volume of stimulated saliva was determined and divided by the duration of saliva collection. The pH was measured directly using a pH meter. The buffering capacity was determined using a quantitative method which involved the addition of 10 ÎŒl HCl. Up to a total of 160 ÎŒL was titrated up to obtain a pH titration curve. At 50 ÎŒL of titrated HCl, buffering capacity was ranked into three categories: high, medium and low. EWPS and nonsmoker groups had similar flow rates (1.81 ± 0.79 and 1.78 ± 1.14 mL min-1) and similar baseline pH (6.60 ± 0.37 and 6.76 ± 0.39). Statistically significant differences in the two groups’ pH were observed from 30 to 160 ÎŒL of titrated up HCl. At 50 ÎŒL of titrated up HCl, the EWPS group compared to the non-smoker group had a significantly higher pH (4.79 ± 0.72 vs. 5.32 ± 0.79). To conclude, waterpipe tobacco smoking alters the buffering capacity but does not alter either salivary flow rates or the baseline pH and consistency

    Orchestration of a large infrastructure of Remote Desktop Windows Servers

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    The CERN Windows Terminal Service infrastructure is an aggregation of multiple virtual servers running Remote Desktop Services, accessed by hundreds of users every day; it has two purposes: provide external access to the CERN network, and exercise access control to certain parts of the accelerator complex. Currently, the deployment and configuration of these servers and services requires some interaction by system administrators, although scripts and tools developed at CERN do contribute to alleviate the problem. Scaling up and down the infrastructure (i.e., adding or removing servers) is also an issue, since it’s done manually. However, recent changes in the infrastructure and the adoption of new software tools that automate software deployment and configuration open new possibilities to improve and orchestrate the current service. Automation and Orchestration will not only reduce the time and effort necessary to deploy new instances, but also simplify operations like patching, analysis and rebuilding of compromised nodes and will provide better performance in response to load increase. The goal of this CERN project, we’re now a part of, is to automate provisioning (and decommissioning) and scaling (up and down) of the infrastructure. Given the scope and magnitude of problems that must be solved, no single solution is capable of addressing all; therefore, multiple technologies are required. For deployment and configuration of Windows Server systems we resort to Puppet, while for orchestration tasks, Microsoft Service Management Automation will be used

    TLS Newsletter Volume 9, Edition 1 September, 2014.

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    Inside the Newsletter: TLS Fall Kick-off Meeting. TLS President\u27s Corner. Upcoming Events. Get to Know Fallon McDonald, TLS Newsletter Editor. T & L Fall Career Day 2014. Jump-start your career--How to Graduate with a Degree and a Job. UNF T & L Students Travel to National Conferences. Life After Graduation with Veer Patel

    A smartphone-based health care chatbot to promote self-management of chronic pain (SELMA) : pilot randomized controlled trial

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    Background: Ongoing pain is one of the most common diseases and has major physical, psychological, social, and economic impacts. A mobile health intervention utilizing a fully automated text-based health care chatbot (TBHC) may offer an innovative way not only to deliver coping strategies and psychoeducation for pain management but also to build a working alliance between a participant and the TBHC. Objective: The objectives of this study are twofold: (1) to describe the design and implementation to promote the chatbot painSELfMAnagement (SELMA), a 2-month smartphone-based cognitive behavior therapy (CBT) TBHC intervention for pain self-management in patients with ongoing or cyclic pain, and (2) to present findings from a pilot randomized controlled trial, in which effectiveness, influence of intention to change behavior, pain duration, working alliance, acceptance, and adherence were evaluated. Methods: Participants were recruited online and in collaboration with pain experts, and were randomized to interact with SELMA for 8 weeks either every day or every other day concerning CBT-based pain management (n=59), or weekly concerning content not related to pain management (n=43). Pain-related impairment (primary outcome), general well-being, pain intensity, and the bond scale of working alliance were measured at baseline and postintervention. Intention to change behavior and pain duration were measured at baseline only, and acceptance postintervention was assessed via self-reporting instruments. Adherence was assessed via usage data. Results: From May 2018 to August 2018, 311 adults downloaded the SELMA app, 102 of whom consented to participate and met the inclusion criteria. The average age of the women (88/102, 86.4%) and men (14/102, 13.6%) participating was 43.7 (SD 12.7) years. Baseline group comparison did not differ with respect to any demographic or clinical variable. The intervention group reported no significant change in pain-related impairment (P=.68) compared to the control group postintervention. The intention to change behavior was positively related to pain-related impairment (P=.01) and pain intensity (P=.01). Working alliance with the TBHC SELMA was comparable to that obtained in guided internet therapies with human coaches. Participants enjoyed using the app, perceiving it as useful and easy to use. Participants of the intervention group replied with an average answer ratio of 0.71 (SD 0.20) to 200 (SD 58.45) conversations initiated by SELMA. Participants’ comments revealed an appreciation of the empathic and responsible interaction with the TBHC SELMA. A main criticism was that there was no option to enter free text for the patients’ own comments. Conclusions: SELMA is feasible, as revealed mainly by positive feedback and valuable suggestions for future revisions. For example, the participants’ intention to change behavior or a more homogenous sample (eg, with a specific type of chronic pain) should be considered in further tailoring of SELMA

    Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

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    Abstract The scaffold protein DLGAP1 is localized at the post-synaptic density (PSD) of glutamatergic neurons and is a component of supramolecular protein complexes organized by PSD95. Gain-of-function variants of DLGAP1 have been associated with obsessive-compulsive disorder (OCD), while haploinsufficient variants have been linked to autism spectrum disorder (ASD) and schizophrenia in human genetic studies. We tested male and female Dlgap1 wild type (WT), heterozygous (HT), and knockout (KO) mice in a battery of behavioral tests: open field, dig, splash, prepulse inhibition, forced swim, nest building, social approach, and sucrose preference. We also used biochemical approaches to examine the role of DLGAP1 in the organization of PSD protein complexes. Dlgap1 KO mice were most notable for disruption of protein interactions in the PSD, and deficits in sociability. Other behavioral measures were largely unaffected. Our data suggest that Dlgap1 knockout leads to PSD disruption and reduced sociability, consistent with reports of DLGAP1 haploinsufficient variants in schizophrenia and ASD

    Can Gender Pronouns in Interview Questions Work as Nudges?

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    Organizations that are historically male-dominated have struggled to attract and retain an equitable representation of women (Debs et al., 2021; Germain et al., 2012; Hall et al., 2018) Using the two systems processing model from Cognitive Psychology, this study assessed whether gender pronouns can function as environmental cues (“nudges”) to disrupt the patterns of mental models on biases and stereotypes. It was proposed that participants can be “nudged” to decrease the impact of gender stereotype biases in the interview process in male-dominated professions (e.g., Information Technology) such that pronouns used in the interview questions will interact with the interviewee’s gender. Results from 1056 participants (Male = 498, Female = 558) revealed that proposed interaction was not supported, indicating that female pronouns did not improve female participants’ selection performance, interviewee engagement and other outcomes, but main effects by gender and by pronoun condition were found to be significant. Across conditions, women scored higher on Situational Judgment Test, used more words in Situational Interviews, while men took a longer time to respond, reported a higher sense of belonging, a higher intent to pursue employment and higher perceived organizational support. Across genders, the “you” condition had a higher score on word count (WTS = 12.57, p \u3c .05) and intent to pursue employment (WTS = 7.1, p \u3c .05). This is indicative that using second person “you” in scenarios may help participants assume the perspective of the agent, thus transcending the problems that may come with third-person pronouns

    Managing Competing Concerns in Digital Innovation:Examining Welfare Technology in Denmark

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    TLS Newsletter Volume 7, Edition 5. February, 2013

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    Inside the Newsletter: TLS Presdient\u27s Corner Brandon Little. TLS Meeting--Harness the power of a professional network, Wednesday, February 20th. Upcoming Events. Launching a Successful Career in Logistics--The Journey Starts at UNF. Get to Know Mark Smill. TLS On Tour--Vistakon Henry Schein Distribution Center. Life after graduation with Paula Nelson
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