Cerebral activations related to ballistic, stepwise interrupted and gradually modulated movements in parkinson patients

Patients with Parkinson's disease (PD) experience impaired initiation and inhibition of movements such as difficulty to start/stop walking. At single-joint level this is accompanied by reduced inhibition of antagonist muscle activity. While normal basal ganglia (BG) contributions to motor control include selecting appropriate muscles by inhibiting others, it is unclear how PD-related changes in BG function cause impaired movement initiation and inhibition at single-joint level. To further elucidate these changes we studied 4 right-hand movement tasks with fMRI, by dissociating activations related to abrupt movement initiation, inhibition and gradual movement modulation. Initiation and inhibition were inferred from ballistic and stepwise interrupted movement, respectively, while smooth wrist circumduction enabled the assessment of gradually modulated movement. Task-related activations were compared between PD patients (N = 12) and healthy subjects (N = 18). In healthy subjects, movement initiation was characterized by antero-ventral striatum, substantia nigra (SN) and premotor activations while inhibition was dominated by subthalamic nucleus (STN) and pallidal activations, in line with the known role of these areas in simple movement. Gradual movement mainly involved antero-dorsal putamen and pallidum. Compared to healthy subjects, patients showed reduced striatal/SN and increased pallidal activation for initiation, whereas for inhibition STN activation was reduced and striatal-thalamo-cortical activation increased. For gradual movement patients showed reduced pallidal and increased thalamo-cortical activation. We conclude that PD-related changes during movement initiation fit the (rather static) model of alterations in direct and indirect BG pathways. Reduced STN activation and regional cortical increased activation in PD during inhibition and gradual movement modulation are better explained by a dynamic model that also takes into account enhanced responsiveness to external stimuli in this disease and the effects of hyper-fluctuating cortical inputs to the striatum and STN in particular

Accuracy, Stability, and Corrective Behavior in a Visuomotor Tracking Task: A Preliminary Study

Visuomotor tracking tasks have been used to elucidate the underlying mechanisms that allow for the coordination of a movement to an environmental event. The main purpose of the present study was to examine the relationship between accuracy and stability of tracking performance and the amount of corrective movements that emerge for various coordination patterns in a unimanual visuomotor tracking task. Participants (N = 6) produced rhythmic elbow flexion–extension motions and were required to track an external sinusoidal signal at five different relative phases, 0°, 45°, 90°, 135°, and 180°. Differential accuracy and stability were found among the five tracking patterns with the 0° relative phase pattern being the most accurate and stable pattern. Corrective movements were correlated with changes in accuracy only for the 0° relative phase pattern, with more corrections emerging for less accurate performance. The amount of corrective movements decreased as the stability of tracking performance increased for the 0°, 45°, and 135° patterns. For the 90° and 180° tracking patterns, the amount of corrective movements was not correlated with pattern accuracy or pattern stability. The results demonstrate that corrective behaviors are an important motor process in maintaining the stability of stable perception-action coordination patterns, while offering little benefit for unstable perception-action patterns

Effects of an active visuomotor steering task on covert attention

In complex dynamic tasks such as driving it is essential to be aware of potentially important targets in peripheral vision. While eye tracking methods in various driving tasks have provided much information about drivers’ gaze strategies, these methods only inform about overt attention and provide limited grounds to assess hypotheses concerning covert attention. We adapted the Posner cue paradigm to a dynamic steering task in a driving simulator. The participants were instructed to report the presence of peripheral targets while their gaze was fixed to the road. We aimed to see whether and how the active steering task and complex visual stimulus might affect directing covert attention to the visual periphery. In a control condition, the detection task was performed without a visual scene and active steering. Detection performance in bends was better in the control task compared to corresponding performance in the steering task, indicating that active steering and the complex visual scene affected the ability to distribute covert attention. Lower targets were discriminated slower than targets at the level of the fixation circle in both conditions. We did not observe higher discriminability for on-road targets. The results may be accounted for by either bottom-up optic flow biasing of attention, or top-down saccade planning.Peer reviewe

Visual control of flight speed in Drosophila melanogaster

Flight control in insects depends on self-induced image motion (optic flow), which the visual system must process to generate appropriate corrective steering maneuvers. Classic experiments in tethered insects applied rigorous system identification techniques for the analysis of turning reactions in the presence of rotating pattern stimuli delivered in open-loop. However, the functional relevance of these measurements for visual free-flight control remains equivocal due to the largely unknown effects of the highly constrained experimental conditions. To perform a systems analysis of the visual flight speed response under free-flight conditions, we implemented a `one-parameter open-loop' paradigm using `TrackFly' in a wind tunnel equipped with real-time tracking and virtual reality display technology. Upwind flying flies were stimulated with sine gratings of varying temporal and spatial frequencies, and the resulting speed responses were measured from the resulting flight speed reactions. To control flight speed, the visual system of the fruit fly extracts linear pattern velocity robustly over a broad range of spatio–temporal frequencies. The speed signal is used for a proportional control of flight speed within locomotor limits. The extraction of pattern velocity over a broad spatio–temporal frequency range may require more sophisticated motion processing mechanisms than those identified in flies so far. In Drosophila, the neuromotor pathways underlying flight speed control may be suitably explored by applying advanced genetic techniques, for which our data can serve as a baseline. Finally, the high-level control principles identified in the fly can be meaningfully transferred into a robotic context, such as for the robust and efficient control of autonomous flying micro air vehicles

No consistent effect of cerebellar transcranial direct current stimulation (tDCS) on visuomotor adaptation

Cerebellar transcranial direct current stimulation (ctDCS) is known to enhance motor adaptation and thus holds promise as a therapeutic intervention. However, understanding the reliability of ctDCS across varying task parameters is crucial. To examine this, we investigated whether ctDCS enhanced visuomotor adaptation across a range of varying task parameters. We found ctDCS to have no consistent effect on visuomotor adaptation, questioning the validity of using ctDCS within a clinical context. </jats:p

Dynamics of eye-hand coordination are flexibly preserved in eye-cursor coordination during an online, digital, object interaction task

Do patterns of eye-hand coordination observed during real-world object interactions apply to digital, screen-based object interactions? We adapted a real-world object interaction task (physically transferring cups in sequence about a tabletop) into a two-dimensional screen-based task (dragging-and-dropping circles in sequence with a cursor). We collected gaze (with webcam eye-tracking) and cursor position data from 51 fully-remote, crowd-sourced participants who performed the task on their own computer. We applied real-world time-series data segmentation strategies to resolve the self-paced movement sequence into phases of object interaction and rigorously cleaned the webcam eye-tracking data. In this preliminary investigation, we found that: 1) real-world eye-hand coordination patterns persist and adapt in this digital context, and 2) remote, online, cursor-tracking and webcam eye-tracking are useful tools for capturing visuomotor behaviours during this ecologically-valid human-computer interaction task. We discuss how these findings might inform design principles and further investigations into natural behaviours that persist in digital environments

Behavioral, computational, and neuroimaging studies of acquired apraxia of speech

A critical examination of speech motor control depends on an in-depth understanding of network connectivity associated with Brodmann areas 44 and 45 and surrounding cortices. Damage to these areas has been associated with two conditions-the speech motor programming disorder apraxia of speech (AOS) and the linguistic/grammatical disorder of Broca's aphasia. Here we focus on AOS, which is most commonly associated with damage to posterior Broca's area (BA) and adjacent cortex. We provide an overview of our own studies into the nature of AOS, including behavioral and neuroimaging methods, to explore components of the speech motor network that are associated with normal and disordered speech motor programming in AOS. Behavioral, neuroimaging, and computational modeling studies are indicating that AOS is associated with impairment in learning feedforward models and/or implementing feedback mechanisms and with the functional contribution of BA6. While functional connectivity methods are not yet routinely applied to the study of AOS, we highlight the need for focusing on the functional impact of localized lesions throughout the speech network, as well as larger scale comparative studies to distinguish the unique behavioral and neurological signature of AOS. By coupling these methods with neural network models, we have a powerful set of tools to improve our understanding of the neural mechanisms that underlie AOS, and speech production generally

Eye-Hand Coordination during Dynamic Visuomotor Rotations

Background for many technology-driven visuomotor tasks such as tele-surgery, human operators face situations in which the frames of reference for vision and action are misaligned and need to be compensated in order to perform the tasks with the necessary precision. The cognitive mechanisms for the selection of appropriate frames of reference are still not fully understood. This study investigated the effect of changing visual and kinesthetic frames of reference during wrist pointing, simulating activities typical for tele-operations. Methods using a robotic manipulandum, subjects had to perform center-out pointing movements to visual targets presented on a computer screen, by coordinating wrist flexion/extension with abduction/adduction. We compared movements in which the frames of reference were aligned (unperturbed condition) with movements performed under different combinations of visual/kinesthetic dynamic perturbations. The visual frame of reference was centered to the computer screen, while the kinesthetic frame was centered around the wrist joint. Both frames changed their orientation dynamically (angular velocity\u200a=\u200a36\ub0/s) with respect to the head-centered frame of reference (the eyes). Perturbations were either unimodal (visual or kinesthetic), or bimodal (visual+kinesthetic). As expected, pointing performance was best in the unperturbed condition. The spatial pointing error dramatically worsened during both unimodal and most bimodal conditions. However, in the bimodal condition, in which both disturbances were in phase, adaptation was very fast and kinematic performance indicators approached the values of the unperturbed condition. Conclusions this result suggests that subjects learned to exploit an \u201caffordance\u201d made available by the invariant phase relation between the visual and kinesthetic frames. It seems that after detecting such invariance, subjects used the kinesthetic input as an informative signal rather than a disturbance, in order to compensate the visual rotation without going through the lengthy process of building an internal adaptation model. Practical implications are discussed as regards the design of advanced, high-performance man-machine interfaces

EEG Source Localization of Visual and Proprioceptive Error Processing During Visually-Guided Target Tracking with the Wrist

Sensorimotor error feedback plays an integral role in movement; it adapts the sensorimotor control system to rapid changes in environmental loads and allows smooth limb coordination. Studies have shown the cerebellum, parietal, and premotor cortices to be involved in error processing, but the specific neural function of those areas remain relatively unknown. The objective of this study was to characterize the neural sources that underlie the computation of visual and proprioceptive error during goal-directed movement. We tested the hypothesis that the cortical networks meditating the two sensory error systems are distinct. Subjects (n=7) used a cursor to track a moving target presented on a computer display. Cursor position on the screen was yoked to a 1-D wrist manipulandum that recorded wrist position, velocity, and torque and applied controlled torques to the wrist. External displacement errors were applied as either force perturbations to the wrist (Proprioceptive condition) or visual displacements to cursor position (Visual condition). Five levels of displacement were applied to identify neural responses that co-varied with the magnitude of displacement. EEG was collected from 64 electrodes. Distributed cortical source modeling (Brainstorm v.3) identified cortical sources that contributed to the averaged EEG activity across error levels. In force perturbation trials, current source density across subjects showed early somatosensory, premotor, motor, and frontal activity ranging from 43±5 ms to 48±6 ms, followed by parietal activity at 70±8 ms. In visual perturbation trials, parietal activation at 113±8 ms was followed by sensory, motor, and premotor activation (123±42 ms to 131±22 ms). Spatial analyses suggest error representations for proprioception and vision may be computed in spatially distinct areas of frontal and parietal cortices. The temporal sequence of error-related activity suggests that sensorimotor error may not initially be computed in parietal regions before being processed in motor areas. The early premotor/motor activation in the Proprioceptive condition suggests that a course estimate of error is first computed in those areas before a more accurate representation of error is generated in the parietal regions. This may occur to initiate a course correction faster in the direction of the error while gathering more information about the error