341,108 research outputs found
Systems validation: application to statistical programs
BACKGROUND: In 2003, the United States Food and Drug Administration (FDA) released a guidance document on the scope of "Part 11" enforcement. In this guidance document, the FDA indicates an expectation of a risk-based approach to determining which systems should undergo validation. Since statistical programs manage and manipulate raw data, their implementation should be critically reviewed to determine whether or not they should undergo validation. However, the concepts of validation are not often discussed in biostatistics curriculum. DISCUSSION: This paper summarizes a "Plan, Do, Say" approach to validation that can be incorporated into statistical training so that biostatisticians can understand and implement validation principles in their research. SUMMARY: Validation is a process that requires dedicated attention. The process of validation can be easily understood in the context of the scientific method
‘Deliberate Preparation’ as an evidence-based focus for primary physical education
There is substantial scientific research suggesting the physical and psychological health benefits of a physically active lifestyle. Consequently, governments worldwide prioritize policies, finances, and resources in healthcare, education, and sports sectors to increase mass participation in physical activity. However, practices in physical activity promotion are often not underpinned by evidence-based standardization that is requisite in other domains of epidemiology. The aim of this article is to examine critically the available scientific research on promoting life-long physical activity participation and to propose an evidence-based model for implementation in school physical education. Reasons are discussed as to why programs that integrate physical, psychological, and behavioral skills have been long acknowledged in physical education and physical activity domains but remain lacking in empirical validation. Finally, future directions are suggested that are required to examine the application of this approach to practice in primary-level physical education
Molecular Dynamics Simulation of Macromolecules Using Graphics Processing Unit
Molecular dynamics (MD) simulation is a powerful computational tool to study
the behavior of macromolecular systems. But many simulations of this field are
limited in spatial or temporal scale by the available computational resource.
In recent years, graphics processing unit (GPU) provides unprecedented
computational power for scientific applications. Many MD algorithms suit with
the multithread nature of GPU. In this paper, MD algorithms for macromolecular
systems that run entirely on GPU are presented. Compared to the MD simulation
with free software GROMACS on a single CPU core, our codes achieve about 10
times speed-up on a single GPU. For validation, we have performed MD
simulations of polymer crystallization on GPU, and the results observed
perfectly agree with computations on CPU. Therefore, our single GPU codes have
already provided an inexpensive alternative for macromolecular simulations on
traditional CPU clusters and they can also be used as a basis to develop
parallel GPU programs to further speedup the computations.Comment: 21 pages, 16 figure
A review on the prevention of inflammatory periimplant diseases
Background: An impressive number of dental implants are inserted worldwide. Evolution in dental implants and simplification of surgical techniques allowed a significant increase in the number of dentists involved in implant surgery. Most of them are general dentists, are not always sufficiently formed and experienced, frequently use low-quality implants, do not adopt the proper patient selective criteria, do not adequately monitor and maintain the inserted implants, and do not report their own statistics to the dental community. Consequently, the incidence of inflammatory periimplant diseases (IPDs) has progressively increased to values significantly higher than those previously indicated by the scientific literature. Materials and Methods: Two main literature searches were undertaken in October 2018 in the PubMed Website database. Only articles written in English and published from 2008 onward were considered; 'Clinical Trial,' 'Meta analysis,' 'Observational study,' 'Review,' and 'Validation study' were selected as article type filters. The following keywords were used in the searches: 'Peri implantitis prevention' and 'Dental implant failure prevention.'Results: Preventive measures are analyzed according to the different factors that can favor the occurrence of an infection. The factors are divided into (i) implant dependent, (ii) patient dependent, and (iii) surgeon dependent. Conclusions: Scientific and clinical data confirm that when materials are selected with care, patients are carefully evaluated for factors of risk and attitude to adhere to the necessary maintenance program, and operative protocols and maintenance programs are respected dental implants can be attractive and effective tools for oral rehabilitation. Nevertheless, dentists and patients should have greater awareness that in many cases the decision to utilize dental implants cannot be taken lightly
CIAO: the CNR-IMAA advanced observatory for atmospheric research
Long-term observations of aerosol and clouds are of crucial importance to understand the weather climate system. At the Istituto di Metodologie per l'Analisi Ambientale of the Italian National Research Council (CNR-IMAA) an advanced atmospheric observatory, named CIAO, is operative. CIAO (CNR-IMAA Atmospheric Observatory) main scientific objective is the long term measurement for the climatology of aerosol and cloud properties. Its equipment addresses the state-of-the-art for the ground-based remote sensing of aerosol, water vapour and clouds including active and passive sensors, like lidars, ceilometers, radiometers, and a radar. This paper describes the CIAO infrastructure, its scientific activities as well as the observation strategy. The observation strategy is mainly organized in order to provide quality assured measurements for satellite validation and model evaluation and to fully exploit the synergy and integration of the active and passive sensors for the improvement of atmospheric profiling. Data quality is ensured both by the application of protocols and dedicated quality assurance programs mainly related to the projects and networks in which the infrastructure is involved. The paper also introduces examples of observations performed at CIAO and of the synergies and integration algorithms (using Raman lidar and microwave profiler data) developed and implemented at the observatory for the optimization and improvement of water vapour profiling. CIAO database represents an optimal basis to study the synergy between different sensors and to investigate aerosol-clouds interactions, and can give a significant contribution to the validation programs of the incoming new generation satellite missions
Recommended from our members
Applying an abstract data structure description approach to parallelizing scientific pointer programs
Even though impressive progress has been made in the area of parallelizing scientific programs with arrays, the application of similar techniques to programs with pointer data structures has remained difficult. Unlike arrays which have a small number of well-defined properties that can be utilized by a parallelizing compiler, pointer data structures are used to implement a wide variety of structures that exhibit a much more diverse set of properties. The complexity and diversity of such properties means that, in general, scientific programs with pointer data structures cannot be effectively analyzed by an optimizing and parallelizing compiler.In order to provide a system in which the compiler can fully utilize the properties of different types of pointer data structures, we have developed a mechanism for the Abstract Description of Data Structures (ADDS). With our approach, the programmer can explicitly describe important properties such as dimensionality of the pointer data structure, independence of dimensions, and direction of traversal. These abstract descriptions of pointer data structures are then used by the compiler to guide analysis, optimization, and parallelization.In this paper we summarize the ADDS approach through the use of numerous examples of data structures used in scientific computations, we illustrate how such declarations are natural and non-tedious to specify, and we show how the ADDS declarations can be used to improve compile-time analysis. In order to demonstrate the viability of our approach, we show how such techniques can be used to parallelize an important class of scientific codes which naturally use recursive pointer data structures. In particular, we use our approach to develop the parallelization of an N-body simulation that is based on a relatively complicated pointer data structure, and we report the speedup results for a Sequent multiprocessor
The Nuclear Spectroscopic Telescope Array (NuSTAR)
The Nuclear Spectroscopic Telescope Array (NuSTAR) is a NASA Small Explorer
mission that will carry the first focusing hard X-ray (5 -- 80 keV) telescope
to orbit. NuSTAR will offer a factor 50 -- 100 sensitivity improvement compared
to previous collimated or coded mask imagers that have operated in this energy
band. In addition, NuSTAR provides sub-arcminute imaging with good spectral
resolution over a 12-arcminute field of view. After launch, NuSTAR will carry
out a two-year primary science mission that focuses on four key programs:
studying the evolution of massive black holes through surveys carried out in
fields with excellent multiwavelength coverage, understanding the population of
compact objects and the nature of the massive black hole in the center of the
Milky Way, constraining explosion dynamics and nucleosynthesis in supernovae,
and probing the nature of particle acceleration in relativistic jets in active
galactic nuclei. A number of additional observations will be included in the
primary mission, and a guest observer program will be proposed for an extended
mission to expand the range of scientific targets. The payload consists of two
co-aligned depth-graded multilayer coated grazing incidence optics focused onto
solid state CdZnTe pixel detectors. To be launched in early 2012 on a Pegasus
rocket into a low-inclination Earth orbit. Data will be publicly available at
GSFC's High Energy Astrophysics Science Archive Research Center (HEASARC)
following validation at the science operations center located at Caltech.Comment: 9 pages, 5 figures, to appear in Proceedings of the SPIE, Space
Telescopes and Instrumentation 2010: Ultraviolet to Gamma Ra
- …