Emotional Experience, Paranoia, and Probabilistic Reasoning in Schizophrenia

Schizophrenia (SZ) is a chronic mental disorder characterized by longstanding and severe social functioning deficits. In trying to better understand psychosocial factors that perpetuate these functional deficits, this dissertation included three studies that examine cognitive and affective factors with the potential to improve functional outcomes in SZ: 1) emotional experience, 2) paranoia, and 3) reasoning. Study one examined negative/positive affect and social functioning with self-report measures among SZ, affective disorders, and the general population. Study 2 assessed paranoia and its relationship with the interpretation of the environment via affective sound localization in SZ. Study 3 compared probabilistic reasoning when estimating the likely source of threatening and non-threatening affective stimuli while also examining the relationship between probabilistic reasoning and delusional thinking in SZ. The findings of this dissertation suggest that for people with schizophrenia: 1) treatment of heightened negative affect and reduced positive affect may improve social functioning, 2) paranoia may aid localization of natural sounds that occur in the environment, and 3) promoting more conservative probabilistic reasoning may help to reduce delusional thinking.PHDPsychologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/146039/1/tylerg_1.pd

Contemp Clin Trials

ObjectiveOnline crowdsourcing refers to the process of obtaining needed services, ideas, or content by soliciting contributions from a large group of people over the Internet. We examined the potential for using online crowdsourcing methods for conducting behavioral health intervention research among people with serious mental illness (SMI).MethodsSystematic review of randomized trials using online crowdsourcing methods for recruitment, intervention delivery, and data collection in people with SMI, including schizophrenia spectrum disorders and mood disorders. Included studies were completed entirely over the Internet without any face-to-face contact between participants and researchers.Databases and sourcesMedline, Cochrane Library, Web of Science, CINAHL, Scopus, PsychINFO, Google Scholar, and reference lists of relevant articles.ResultsWe identified 7 randomized trials that enrolled N=1,214 participants (range: 39 to 419) with SMI. Participants were mostly female (72%) and had mood disorders (94%). Attrition ranged from 14% to 81%. Three studies had attrition rates below 25%. Most interventions were adapted from existing evidence-based programs, and consisted of self-directed education, psychoeducation, self-help, and illness self-management. Six studies collected self-reported mental health symptoms, quality of life, and illness severity. Three studies supported intervention effectiveness and two studies showed improvements in the intervention and comparison conditions over time. Peer support emerged as an important component of several interventions. Overall, studies were of medium to high methodological quality.ConclusionOnline crowdsourcing methods appear feasible for conducting intervention research in people with SMI. Future efforts are needed to improve retention rates, collect objective outcome measures, and reach a broader demographic.R01 MH104555/MH/NIMH NIH HHS/United StatesU48 DP005018/DP/NCCDPHP CDC HHS/United States2017-01-16T00:00:00Z26188164PMC471579

Medical Crowdsourcing: Harnessing the “Wisdom of the Crowd” to Solve Medical Mysteries

Medical crowdsourcing offers hope to patients who suffer from complex health conditions that are difficult to diagnose. Such crowdsourcing platforms empower patients to harness the “wisdom of the crowd” by providing access to a vast pool of diverse medical knowledge. Greater participation in crowdsourcing increases the likelihood of encountering a correct solution. However, more participation also leads to increased “noise,” which makes identifying the most likely solution from a broader pool of recommendations (i.e., diagnostic suggestions) difficult. The challenge for medical crowdsourcing platforms is to increase participation of both patients and solution providers, while simultaneously increasing the efficacy and accuracy of solutions. The primary objectives of this study are: (1) to investigate means to enhance the solution pool by increasing participation of solution providers referred to as “medical detectives” or “detectives,” and (2) to explore ways of selecting the most likely diagnosis from a set of alternative possibilities recommended by medical detectives. Our results suggest that our strategy of using multiple methods for evaluating recommendations by detectives leads to better predictions. Furthermore, cases with higher perceived quality and more negative emotional tones (e.g., sadness, fear, and anger) attract more detectives. Our findings have strong implications for research and practice

Emerging technologies to measure neighborhood conditions in public health: Implications for interventions and next steps

Adverse neighborhood conditions play an important role beyond individual characteristics. There is increasing interest in identifying specific characteristics of the social and built environments adversely affecting health outcomes. Most research has assessed aspects of such exposures via self-reported instruments or census data. Potential threats in the local environment may be subject to short-term changes that can only be measured with more nimble technology. The advent of new technologies may offer new opportunities to obtain geospatial data about neighborhoods that may circumvent the limitations of traditional data sources. This overview describes the utility, validity and reliability of selected emerging technologies to measure neighborhood conditions for public health applications. It also describes next steps for future research and opportunities for interventions. The paper presents an overview of the literature on measurement of the built and social environment in public health (Google Street View, webcams, crowdsourcing, remote sensing, social media, unmanned aerial vehicles, and lifespace) and location-based interventions. Emerging technologies such as Google Street View, social media, drones, webcams, and crowdsourcing may serve as effective and inexpensive tools to measure the ever-changing environment. Georeferenced social media responses may help identify where to target intervention activities, but also to passively evaluate their effectiveness. Future studies should measure exposure across key time points during the life-course as part of the exposome paradigm and integrate various types of data sources to measure environmental contexts. By harnessing these technologies, public health research can not only monitor populations and the environment, but intervene using novel strategies to improve the public health

What Symptoms and How Long? An Interpretable AI Approach for Depression Detection in Social Media

Depression is the most prevalent and serious mental illness, which induces grave financial and societal ramifications. Depression detection is key for early intervention to mitigate those consequences. Such a high-stake decision inherently necessitates interpretability. Although a few depression detection studies attempt to explain the decision, these explanations misalign with the clinical depression diagnosis criterion that is based on depressive symptoms. To fill this gap, we develop a novel Multi-Scale Temporal Prototype Network (MSTPNet). MSTPNet innovatively detects and interprets depressive symptoms as well as how long they last. Extensive empirical analyses show that MSTPNet outperforms state-of-the-art depression detection methods. This result also reveals new symptoms that are unnoted in the survey approach. We further conduct a user study to demonstrate its superiority over the benchmarks in interpretability. This study contributes to IS literature with a novel interpretable deep learning model for depression detection in social media

Emotions in context: examining pervasive affective sensing systems, applications, and analyses

Pervasive sensing has opened up new opportunities for measuring our feelings and understanding our behavior by monitoring our affective states while mobile. This review paper surveys pervasive affect sensing by examining and considering three major elements of affective pervasive systems, namely; “sensing”, “analysis”, and “application”. Sensing investigates the different sensing modalities that are used in existing real-time affective applications, Analysis explores different approaches to emotion recognition and visualization based on different types of collected data, and Application investigates different leading areas of affective applications. For each of the three aspects, the paper includes an extensive survey of the literature and finally outlines some of challenges and future research opportunities of affective sensing in the context of pervasive computing

Social media mental health analysis framework through applied computational approaches

Studies have shown that mental illness burdens not only public health and productivity but also established market economies throughout the world. However, mental disorders are difficult to diagnose and monitor through traditional methods, which heavily rely on interviews, questionnaires and surveys, resulting in high under-diagnosis and under-treatment rates. The increasing use of online social media, such as Facebook and Twitter, is now a common part of people’s everyday life. The continuous and real-time user-generated content often reflects feelings, opinions, social status and behaviours of individuals, creating an unprecedented wealth of person-specific information. With advances in data science, social media has already been increasingly employed in population health monitoring and more recently mental health applications to understand mental disorders as well as to develop online screening and intervention tools. However, existing research efforts are still in their infancy, primarily aimed at highlighting the potential of employing social media in mental health research. The majority of work is developed on ad hoc datasets and lacks a systematic research pipeline. [Continues.]</div