High-Throughput Classification of Radiographs Using Deep Convolutional Neural Networks.

The study aimed to determine if computer vision techniques rooted in deep learning can use a small set of radiographs to perform clinically relevant image classification with high fidelity. One thousand eight hundred eighty-five chest radiographs on 909 patients obtained between January 2013 and July 2015 at our institution were retrieved and anonymized. The source images were manually annotated as frontal or lateral and randomly divided into training, validation, and test sets. Training and validation sets were augmented to over 150,000 images using standard image manipulations. We then pre-trained a series of deep convolutional networks based on the open-source GoogLeNet with various transformations of the open-source ImageNet (non-radiology) images. These trained networks were then fine-tuned using the original and augmented radiology images. The model with highest validation accuracy was applied to our institutional test set and a publicly available set. Accuracy was assessed by using the Youden Index to set a binary cutoff for frontal or lateral classification. This retrospective study was IRB approved prior to initiation. A network pre-trained on 1.2 million greyscale ImageNet images and fine-tuned on augmented radiographs was chosen. The binary classification method correctly classified 100 % (95 % CI 99.73-100 %) of both our test set and the publicly available images. Classification was rapid, at 38 images per second. A deep convolutional neural network created using non-radiological images, and an augmented set of radiographs is effective in highly accurate classification of chest radiograph view type and is a feasible, rapid method for high-throughput annotation

How good is good enough? Strategies for dealing with unreliable segmentation annotations of medical data

Medical image segmentation is an essential topic in computer vision and medical image analysis, because it enables the precise and accurate segmentation of organs and lesions for healthcare applications. Deep learning has dominated in medical image segmentation due to increasingly powerful computational resources, successful neural network architecture engineering, and access to large amounts of medical imaging data with high-quality annotations. However, annotating medical imaging data is time-consuming and expensive, and sometimes the annotations are unreliable. This DPhil thesis presents a comprehensive study that explores deep learning techniques in medical image segmentation under various challenging situations of unreliable medical imaging data. These situations include: (1) conventional supervised learning to tackle comprehensive data annotation with full dense masks, (2) semi-supervised learning to tackle partial data annotation with full dense masks, (3) noise-robust learning to tackle comprehensive data annotation with noisy dense masks, and (4) weakly-supervised learning to tackle comprehensive data annotation with sketchy contours for network training. The proposed medical image segmentation strategies improve deep learning techniques to effectively address a series of challenges in medical image analysis, including limited annotated data, noisy annotations, and sparse annotations. These advancements aim to bring deep learning techniques of medical image analysis into practical clinical scenarios. By overcoming these challenges, the strategies establish a more robust and reliable application of deep learning methods which is valuable for improving diagnostic precision and patient care outcomes in real-world clinical environments

Deep learning from crowds

Over the last few years, deep learning has revolutionized the field of machine learning by dramatically improving the state-of-the-art in various domains. However, as the size of supervised artificial neural networks grows, typically so does the need for larger labeled datasets. Recently, crowdsourcing has established itself as an efficient and cost-effective solution for labeling large sets of data in a scalable manner, but it often requires aggregating labels from multiple noisy contributors with different levels of expertise. In this paper, we address the problem of learning deep neural networks from crowds. We begin by describing an EM algorithm for jointly learning the parameters of the network and the reliabilities of the annotators. Then, a novel general-purpose crowd layer is proposed, which allows us to train deep neural networks end-to-end, directly from the noisy labels of multiple annotators, using only backpropagation. We empirically show that the proposed approach is able to internally capture the reliability and biases of different annotators and achieve new state-of-the-art results for various crowdsourced datasets across different settings, namely classification, regression and sequence labeling.Comment: 10 pages, The Thirty-Second AAAI Conference on Artificial Intelligence (AAAI), 201

Prospects for Theranostics in Neurosurgical Imaging: Empowering Confocal Laser Endomicroscopy Diagnostics via Deep Learning

Confocal laser endomicroscopy (CLE) is an advanced optical fluorescence imaging technology that has the potential to increase intraoperative precision, extend resection, and tailor surgery for malignant invasive brain tumors because of its subcellular dimension resolution. Despite its promising diagnostic potential, interpreting the gray tone fluorescence images can be difficult for untrained users. In this review, we provide a detailed description of bioinformatical analysis methodology of CLE images that begins to assist the neurosurgeon and pathologist to rapidly connect on-the-fly intraoperative imaging, pathology, and surgical observation into a conclusionary system within the concept of theranostics. We present an overview and discuss deep learning models for automatic detection of the diagnostic CLE images and discuss various training regimes and ensemble modeling effect on the power of deep learning predictive models. Two major approaches reviewed in this paper include the models that can automatically classify CLE images into diagnostic/nondiagnostic, glioma/nonglioma, tumor/injury/normal categories and models that can localize histological features on the CLE images using weakly supervised methods. We also briefly review advances in the deep learning approaches used for CLE image analysis in other organs. Significant advances in speed and precision of automated diagnostic frame selection would augment the diagnostic potential of CLE, improve operative workflow and integration into brain tumor surgery. Such technology and bioinformatics analytics lend themselves to improved precision, personalization, and theranostics in brain tumor treatment.Comment: See the final version published in Frontiers in Oncology here: https://www.frontiersin.org/articles/10.3389/fonc.2018.00240/ful

Who Said What: Modeling Individual Labelers Improves Classification

Data are often labeled by many different experts with each expert only labeling a small fraction of the data and each data point being labeled by several experts. This reduces the workload on individual experts and also gives a better estimate of the unobserved ground truth. When experts disagree, the standard approaches are to treat the majority opinion as the correct label or to model the correct label as a distribution. These approaches, however, do not make any use of potentially valuable information about which expert produced which label. To make use of this extra information, we propose modeling the experts individually and then learning averaging weights for combining them, possibly in sample-specific ways. This allows us to give more weight to more reliable experts and take advantage of the unique strengths of individual experts at classifying certain types of data. Here we show that our approach leads to improvements in computer-aided diagnosis of diabetic retinopathy. We also show that our method performs better than competing algorithms by Welinder and Perona (2010), and by Mnih and Hinton (2012). Our work offers an innovative approach for dealing with the myriad real-world settings that use expert opinions to define labels for training.Comment: AAAI 201