Towards a virtual research environment for paediatric endocrinology across Europe

Paediatric endocrinology is a medical specialty dealing with variations of physical growth and sexual development in childhood. Genetic anomalies that can cause disorders of sexual development in children are rare. Given this, sharing and collaboration on the small number of cases that occur is needed by clinical experts in the field. The EU-funded EuroDSD project (www.eurodsd.eu) is one such collaboration involving clinical centres and clinical and genetic experts across Europe. Through the establishment of a virtual research environment (VRE) supporting sharing of data and a variety of clinical and bioinformatics analysis tools, EuroDSD aims to provide a research infrastructure for research into disorders of sex development. Security, ethics and information governance are at the heart of this infrastructure. This paper describes the infrastructure that is being built and the inherent challenges in security, availability and dependability that must be overcome for the enterprise to succeed

Integrating IVHM and Asset Design

Integrated Vehicle Health Management (IVHM) describes a set of capabilities that enable effective and efficient maintenance and operation of the target vehicle. It accounts for the collection of data, conducting analysis, and supporting the decision-making process for sustainment and operation. The design of IVHM systems endeavours to account for all causes of failure in a disciplined, systems engineering, manner. With industry striving to reduce through-life cost, IVHM is a powerful tool to give forewarning of impending failure and hence control over the outcome. Benefits have been realised from this approach across a number of different sectors but, hindering our ability to realise further benefit from this maturing technology, is the fact that IVHM is still treated as added on to the design of the asset, rather than being a sub-system in its own right, fully integrated with the asset design. The elevation and integration of IVHM in this way will enable architectures to be chosen that accommodate health ready sub-systems from the supply chain and design trade-offs to be made, to name but two major benefits. Barriers to IVHM being integrated with the asset design are examined in this paper. The paper presents progress in overcoming them, and suggests potential solutions for those that remain. It addresses the IVHM system design from a systems engineering perspective and the integration with the asset design will be described within an industrial design process

Integrating IVHM and asset design

Integrated Vehicle Health Management (IVHM) describes a set of capabilities that enable effective and efficient maintenance and operation of the target vehicle. It accounts for the collecting of data, conducting analysis, and supporting the decision-making process for sustainment and operation. The design of IVHM systems endeavours to account for all causes of failure in a disciplined, systems engineering, manner. With industry striving to reduce through-life cost, IVHM is a powerful tool to give forewarning of impending failure and hence control over the outcome. Benefits have been realised from this approach across a number of different sectors but, hindering our ability to realise further benefit from this maturing technology, is the fact that IVHM is still treated as added on to the design of the asset, rather than being a sub-system in its own right, fully integrated with the asset design. The elevation and integration of IVHM in this way will enable architectures to be chosen that accommodate health ready sub-systems from the supply chain and design trade-offs to be made, to name but two major benefits. Barriers to IVHM being integrated with the asset design are examined in this paper. The paper presents progress in overcoming them, and suggests potential solutions for those that remain. It addresses the IVHM system design from a systems engineering perspective and the integration with the asset design will be described within an industrial design process

A survey on software testability

Context: Software testability is the degree to which a software system or a unit under test supports its own testing. To predict and improve software testability, a large number of techniques and metrics have been proposed by both practitioners and researchers in the last several decades. Reviewing and getting an overview of the entire state-of-the-art and state-of-the-practice in this area is often challenging for a practitioner or a new researcher. Objective: Our objective is to summarize the body of knowledge in this area and to benefit the readers (both practitioners and researchers) in preparing, measuring and improving software testability. Method: To address the above need, the authors conducted a survey in the form of a systematic literature mapping (classification) to find out what we as a community know about this topic. After compiling an initial pool of 303 papers, and applying a set of inclusion/exclusion criteria, our final pool included 208 papers. Results: The area of software testability has been comprehensively studied by researchers and practitioners. Approaches for measurement of testability and improvement of testability are the most-frequently addressed in the papers. The two most often mentioned factors affecting testability are observability and controllability. Common ways to improve testability are testability transformation, improving observability, adding assertions, and improving controllability. Conclusion: This paper serves for both researchers and practitioners as an "index" to the vast body of knowledge in the area of testability. The results could help practitioners measure and improve software testability in their projects

Must Understanding Be Coherent?

Several authors suggest that understanding and epistemic coherence are tightly connected. Using an account of understanding that makes no appeal to coherence, I explain away the intuitions that motivate this position. I then show that the leading coherentist epistemologies only place plausible constraints on understanding insofar as they replicate my own account’s requirements. I conclude that understanding is only superficially coherent

Measuring and comparing the reliability of the structured walkthrough evaluation method with novices and experts

Effective evaluation of websites for accessibility remains problematic. Automated evaluation tools still require a significant manual element. There is also a significant expertise and evaluator effect. The Structured Walkthrough method is the translation of a manual, expert accessibility evaluation process adapted for use by novices. The method is embedded in the Accessibility Evaluation Assistant (AEA), a web accessibility knowledge management tool. Previous trials examined the pedagogical potential of the tool when incorporated into an undergraduate computing curriculum. The results of the evaluations carried out by novices yielded promising, consistent levels of validity and reliability. This paper presents the results of an empirical study that compares the reliability of accessibility evaluations produced by two groups (novices and experts). The main results of this study indicate that overall reliability of expert evaluations was 76% compared to 65% for evaluations produced by novices. The potential of the Structured Walkthrough method as a useful and viable tool for expert evaluators is also examined. Copyright 2014 ACM

What is a model, why people don't trust them, and why they should

It is easier to make one�s way in the world if one has some sort of expectation of the world�s future behaviour. Even when facing a very complex problem, we are rarely in a state of full ignorance: some expectations of system behaviour and the level of risk arising from uncertainty are usually available and it is on the basis of these expectations that most decisions are taken. Humans use models, which are mental or formal representations of reality, to generate these expectations, employing an ability that is shared more or less by all forms of life. Whether it is a tree responding to shortening day length by dropping its leaves and preparing its metabolism for the winter ahead or a naked Pleistocene ape storing food in advance of winter for the same reasons, both are using models. This view leads to two outcomes. The first is that predictions, seen as an expectation of ranges of future behaviours, are not just desirable, but necessary for decision-making. The often-asked question �do models provide reliable predictions?� then shifts to �given a certain problem, what type of models provide the most useful and reliable prediction?� The second outcome is that modelling is no longer a scientist�s activity but is instead a social process. Different types of models can be employed to ensure that all available information is included in model building and that model results are understood, trusted and acted upon