Data-based mechanistic modelling, forecasting, and control.

This article briefly reviews the main aspects of the generic data based mechanistic (DBM) approach to modeling stochastic dynamic systems and shown how it is being applied to the analysis, forecasting, and control of environmental and agricultural systems. The advantages of this inductive approach to modeling lie in its wide range of applicability. It can be used to model linear, nonstationary, and nonlinear stochastic systems, and its exploitation of recursive estimation means that the modeling results are useful for both online and offline applications. To demonstrate the practical utility of the various methodological tools that underpin the DBM approach, the article also outlines several typical, practical examples in the area of environmental and agricultural systems analysis, where DBM models have formed the basis for simulation model reduction, control system design, and forecastin

Nonparametric nonlinear model predictive control

Model Predictive Control (MPC) has recently found wide acceptance in industrial applications, but its potential has been much impeded by linear models due to the lack of a similarly accepted nonlinear modeling or databased technique. Aimed at solving this problem, the paper addresses three issues: (i) extending second-order Volterra nonlinear MPC (NMPC) to higher-order for improved prediction and control; (ii) formulating NMPC directly with plant data without needing for parametric modeling, which has hindered the progress of NMPC; and (iii) incorporating an error estimator directly in the formulation and hence eliminating the need for a nonlinear state observer. Following analysis of NMPC objectives and existing solutions, nonparametric NMPC is derived in discrete-time using multidimensional convolution between plant data and Volterra kernel measurements. This approach is validated against the benchmark van de Vusse nonlinear process control problem and is applied to an industrial polymerization process by using Volterra kernels of up to the third order. Results show that the nonparametric approach is very efficient and effective and considerably outperforms existing methods, while retaining the original data-based spirit and characteristics of linear MPC

Diagnostic and prognostic prediction models in ventilator-associated pneumonia: Systematic review and meta-analysis of prediction modelling studies

Machine learning; Mechanical ventilation; Prognostic modelAprenentatge automàtic; Ventilació mecànica; Model pronòsticAprendizaje automático; Ventilacion mecanica; Modelo pronósticoPurpose Existing expert systems have not improved the diagnostic accuracy of ventilator-associated pneumonia (VAP). The aim of this systematic literature review was to review and summarize state-of-the-art prediction models detecting or predicting VAP from exhaled breath, patient reports and demographic and clinical characteristics. Methods Both diagnostic and prognostic prediction models were searched from a representative list of multidisciplinary databases. An extensive list of validated search terms was added to the search to cover papers failing to mention predictive research in their title or abstract. Two authors independently selected studies, while three authors extracted data using predefined criteria and data extraction forms. The Prediction Model Risk of Bias Assessment Tool was used to assess both the risk of bias and the applicability of the prediction modelling studies. Technology readiness was also assessed. Results Out of 2052 identified studies, 20 were included. Fourteen (70%) studies reported the predictive performance of diagnostic models to detect VAP from exhaled human breath with a high degree of sensitivity and a moderate specificity. In addition, the majority of them were validated on a realistic dataset. The rest of the studies reported the predictive performance of diagnostic and prognostic prediction models to detect VAP from unstructured narratives [2 (10%)] as well as baseline demographics and clinical characteristics [4 (20%)]. All studies, however, had either a high or unclear risk of bias without significant improvements in applicability. Conclusions The development and deployment of prediction modelling studies are limited in VAP and related outcomes. More computational, translational, and clinical research is needed to bring these tools from the bench to the bedside.The project is supported by the Academy of Finland (project number 326291) and the University of Oulu

Optimal greenhouse cultivation control: survey and perspectives

Abstract: A survey is presented of the literature on greenhouse climate control, positioning the various solutions and paradigms in the framework of optimal control. A separation of timescales allows the separation of the economic optimal control problem of greenhouse cultivation into an off-line problem at the tactical level, and an on-line problem at the operational level. This paradigm is used to classify the literature into three categories: focus on operational control, focus on the tactical level, and truly integrated control. Integrated optimal control warrants the best economical result, and provides a systematic way to design control systems for the innovative greenhouses of the future. Research issues and perspectives are listed as well

Advanced and Innovative Optimization Techniques in Controllers: A Comprehensive Review

New commercial power electronic controllers come to the market almost every day to help improve electronic circuit and system performance and efficiency. In DC–DC switching-mode converters, a simple and elegant hysteretic controller is used to regulate the basic buck, boost and buck–boost converters under slightly different configurations. In AC–DC converters, the input current shaping for power factor correction posts a constraint. But, several brilliant commercial controllers are demonstrated for boost and fly back converters to achieve almost perfect power factor correction. In this paper a comprehensive review of the various advanced optimization techniques used in power electronic controllers is presented

Psychiatric characterization of children with genetic causes of hyperandrogenism

Objective: Very little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric morbidity in this group. Design/methods: Children (8-18 years) with the diagnosis of classic congenital adrenal hyperplasia (CAH) or familial male precocious puberty (FMPP) underwent a semi-structured psychiatric interview, the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. According to sex and the literature, incidence of identified psychopathology was compared between the two endocrinological groups. We evaluated 72 patients: 54 CAH (21 females) and 18 FMPP. Results: Twenty-four (44.4%) CAH patients and 10 (55.6%) FMPP patients met the criteria for at least one lifetime psychiatric diagnosis. Attention-deficit hyperactivity disorder (ADHD) was present in 18.2% of CAH males, 44.4% of FMPP males, and one case (4.8%) in CAH females. A high rate of anxiety disorders was also found in all the three groups (17-21%). Relative to females with CAH, the FMPP patients exhibited higher rates of ADHD. Age at diagnosis and the treatment modalities were not associated with psychopathology. Rates of psychiatric disorder, specifically ADHD and anxiety disorders, were higher than in the general population. Conclusion: Although anxiety disorders may occur at an increased rate in children with chronic illness, androgens may contribute to higher risk for psychopathology in pediatric patients with genetic cause of excess androgen. Early diagnosis and treatment of childhood hyperandrogenism is essential for optimal development. The results suggest that assessment for psychiatric disorders should be part of the routine evaluation of these patients

Forecasting VARMA processes using VAR models and subspace-based state space models

VAR modelling is a frequent technique in econometrics for linear processes. VAR modelling offers some desirable features such as relatively simple procedures for model specification (order selection) and the possibility of obtaining quick non-iterative maximum likelihood estimates of the system parameters. However, if the process under study follows a finite-order VARMA structure, it cannot be equivalently represented by any finite-order VAR model. On the other hand, a finite-order state space model can represent a finite-order VARMA process exactly, and, for state-space modelling, subspace algorithms allow for quick and non-iterative estimates of the system parameters, as well as for simple specification procedures. Given the previous facts, we check in this paper whether subspace-based state space models provide better forecasts than VAR models when working with VARMA data generating processes. In a simulation study we generate samples from different VARMA data generating processes, obtain VAR-based and state-space-based models for each generating process and compare the predictive power of the obtained models. Different specification and estimation algorithms are considered; in particular, within the subspace family, the CCA (Canonical Correlation Analysis) algorithm is the selected option to obtain state-space models. Our results indicate that when the MA parameter of an ARMA process is close to 1, the CCA state space models are likely to provide better forecasts than the AR models. We also conduct a practical comparison (for two cointegrated economic time series) of the predictive power of Johansen restricted-VAR (VEC) models with the predictive power of state space models obtained by the CCA subspace algorithm, including a density forecasting analysis.subspace algorithms; VAR; forecasting; cointegration; Johansen; CCA