Therapeutic potential of allicin-rich garlic preparations : emphasis on clinical evidence toward upcoming drugs formulation

Garlic has been used for a long time in human history. Allicin, the main active compound present in freshly injured garlic, is enzymatically formed from alliin. Allicin has shown doubtless beneficial effects and even be conceived as medicine. The present review highlights allicin-associated studies. Indeed, clinical studies on healthy subjects have evidenced that standardized garlic treatment (900 mg/day) significantly reduces total cholesterol (TC) and low-density lipoprotein cholesterol (c-LDL). Besides, allicin also led to a marked improvement in mouth opening, burning sensation, and oral health-related quality of life on stage II oral submucous fibrosis patients. Interestingly, in children, allicin also has been proposed for thrush prevention and as an alternative antibiotic therapy. Nonetheless, there is particular attention to allicin bioavailability, given its high instability. Although clinical evidence has promoted allicin release from garlic powder tablets under simulated gastrointestinal conditions, garlic tablets are those that have provided less alliinase protection due to its fast disintegration, releasing low allicin amounts9245555Natália Martins would like to thank the Portuguese Foundation for Science and Technology (FCT–Portugal) for the Strategic project ref. UID/BIM/04293/2013 and “NORTE2020—Programa Operacional Regional do Norte” (NORTE-01-0145-FEDER-000012

Therapeutic potential of allicin-rich garlic preparations: Emphasis on clinical evidence toward upcoming drugs formulation

Garlic has been used for a long time in human history. Allicin, the main active compound present in freshly injured garlic, is enzymatically formed from alliin. Allicin has shown doubtless beneficial effects and even be conceived as medicine. The present review highlights allicin-associated studies. Indeed, clinical studies on healthy subjects have evidenced that standardized garlic treatment (900 mg/day) significantly reduces total cholesterol (TC) and low-density lipoprotein cholesterol (c-LDL). Besides, allicin also led to a marked improvement in mouth opening, burning sensation, and oral health-related quality of life on stage II oral submucous fibrosis patients. Interestingly, in children, allicin also has been proposed for thrush prevention and as an alternative antibiotic therapy. Nonetheless, there is particular attention to allicin bioavailability, given its high instability. Although clinical evidence has promoted allicin release from garlic powder tablets under simulated gastrointestinal conditions, garlic tablets are those that have provided less alliinase protection due to its fast disintegration, releasing low allicin amounts.Natália Martins would like to thank the Portuguese Foundation for Science and Technology (FCT-Portugal) for the Strategic project ref. UID/BIM/04293/2013 and "NORTE2020-Programa Operacional Regional do Norte" (NORTE-01-0145-FEDER-000012)

Preventive effects of garlic and lemon extract combined with aerobic exercise on blood metabolic parameters and liver enzymes

Purpose: The aim of this study was to evaluate the effects of aerobic exercise in combination with garlic and lemon on the lipid profile, metabolic parameters, and liver enzymes of obese male rats. Design: Sixty-four male Wistar rats were divided into eight equal groups consisting of 1) control following no treatment (n = 8); 2) hypercaloric fatty-food-based diet (n = 8); 3) aerobic exercise (AE, n = 8); 4) garlic intake (G, n = 8); 5) aerobic exercise with garlic intake (AEG, n = 8); 6) lemon intake (L, n = 8); 7) garlic and lemon (GL, n = 8); 8) garlic, lemon and aerobic exercise (GLAE, n = 8). After six weeks of intervention, blood samples were taken to obtain cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and glucose. C-reactive protein (CRP), alanine aminotransferase (GPT), aspartate aminotransferase (GOT), alkaline phosphatase (ALP), creatinine (Cr), urea and uric acid (UA) were also measured. A one-way ANOVA or the Kruskal Wallis tests for the non-normally distributed variables, with post-hoc pairwise comparisons were conducted to assess differences between groups. Results: All the intervention groups obtained significantly better values compared to the hypercaloric group, although being also fed with a hypercaloric diet. In certain parameters, the intervention groups obtained equal or even better results than the control healthy group. The combination of aerobic exercise with the intake of garlic and lemon showed slightly non-significant better results. Conclusion: Aerobic exercise combined with the intake of garlic and lemon juice may influence the lipid profile, liver enzymes, and other blood parameters associated with cardiovascular disease.The authors gratefully acknowledge the cooperation of the Shahrekord Medicinal Plants Research Center, which supported and funded this project

Does the taste matter? Taste and medicinal perceptions associated with five selected herbal drugs among three ethnic groups in West Yorkshire, Northern England

In recent years, diverse scholars have addressed the issue of the chemosensory perceptions associated with traditional medicines, nevertheless there is still a distinct lack of studies grounded in the social sciences and conducted from a cross-cultural, comparative perspective. In this urban ethnobotanical field study, 254 informants belonging to the Gujarati, Kashmiri and English ethnic groups and living in Western Yorkshire in Northern England were interviewed about the relationship between taste and medicinal perceptions of five herbal drugs, which were selected during a preliminary study. The herbal drugs included cinnamon (the dried bark of Cinnamomum verum, Lauraceae), mint (the leaves of Mentha spp., Lamiaceae), garlic (the bulbs of Allium sativum, Alliaceae), ginger (the rhizome of Zingiber officinale, Zingiberaceae), and cloves (the dried flower buds of Syzygium aromaticum, Myrtaceae). The main cross-cultural differences in taste perceptions regarded the perception the perception of the spicy taste of ginger, garlic, and cinnamon, of the bitter taste of ginger, the sweet taste of mint, and of the sour taste of garlic. The part of the study of how the five selected herbal drugs are perceived medicinally showed that TK (Traditional Knowledge) is widespread among Kashmiris, but not so prevalent among the Gujarati and especially the English samples. Among Kashmiris, ginger was frequently considered to be helpful for healing infections and muscular-skeletal and digestive disorders, mint was chosen for healing digestive and respiratory troubles, garlic for blood system disorders, and cinnamon was perceived to be efficacious for infectious diseases. Among the Gujarati and Kashmiri groups there was evidence of a strong link between the bitter and spicy tastes of ginger, garlic, cloves, and cinnamon and their perceived medicinal properties, whereas there was a far less obvious link between the sweet taste of mint and cinnamon and their perceived medicinal properties, although the link did exist among some members of the Gujarati group. Data presented in this study show how that links between taste perceptions and medicinal uses of herbal drugs may be understood as bio-cultural phenomena rooted in human physiology, but also constructed through individual experiences and culture, and that these links can therefore be quite different across diverse cultures

RECIPE SUGGESTION TOOL

ABSTRACTThere is currently a great need for a tool to search cooking recipes based on ingredients. Current search engines do not provide this feature. Most of the recipe search results in current websites are not efficiently clustered based on relevance or categories resulting in a user getting lost in the huge search results presented.Clustering in information retrieval is used for higher efficiency and better presentation of information to the user. Clustering puts similar documents in the same cluster. If a document is relevant to a query, then the documents in the same cluster are also relevant.The goal of this project is to implement clustering on recipes. The user can search for recipes based on ingredient

Natural poultry health

guide to keeping your flock healthy with herbs and other natural product

Developing a participatory approach to seed production and varietal selection (OF0330)

Overall Aim To develop a robust system for identifying, testing, multiplying and marketing cereal varieties, lines, mixtures and populations best suited to organic production in different parts of the country. Objectives 1. Develop a participatory research and development methodology for UK organic farmers using variety trialling and the management of seed-borne disease as examples. 2. Collect information on the range of cereal varieties currently grown by organic farmers to help identify the major priorities and constraints among the varieties available. 3. Establish a pilot programme of cereal variety trials with organic farmers on organic farms using the methodology developed by Objective 1. 4. To obtain information on which seed-borne diseases, including ergot, may cause problems in the organic seed production chain of wheat, barley, oats and triticale, and to examine any relationship between organic husbandry conditions (seed rate, sowing date, rotation etc.) and incidence/severity of disease. 5. Determine whether cultivars with good potential for organic production are resistant to one or more of the seed-borne disease problems. 6. Working with farmers (Objective 1), review and identify a range of organically acceptable seed treatments and processes, considering both chemical and physical methods, and test these under organic conditions to determine efficacy. 7. Formulate a code of best practice for the production of certified organic seed, and for the processing of seed on organic farms. 8. To evaluate the participatory research and development approach throughout the entire research process and produce guidelines and materials for best practice. Data will be collected throughout the duration of the project. Objective 1. A literature review was undertaken and an agenda for future research set out. Questions to be addressed included: Have we identified the research that farmers and other stakeholders want? What roles do farmers and other stakeholders play? How do we carry out the testing, adaptation and development of options? How can the effective forms of participatory research (if there are any) be ‘mainstreamed’ into other agricultural research? Existing systems of farmer involvement in research were also examined through interviews with farmers, agri-businesses and scientists. It was found that almost all farmers were carrying out some kind of research on their farm. This may be using scientific methods or using a more holistic approach with multiple criteria. Farmers may set hypotheses explicitly before starting the experiment or they may use gut feelings and be experimenting without acknowledging it. They also often changed treatments during the experiment. It was concluded that the best results are more likely to come when topics are addressed by combining farmers’ own research with research on farms controlled and managed by scientists. From discussions with various farmer groups and the previous experience of Elm Farm Organic Research Centre researchers, it was decided that: the project should focus on winter wheat; and the basic experimental protocol must be simple, be able to be undertaken by the farmer with their own machinery and within the farmers’ time constraints. A protocol was established and reviewed each year at annual post harvest review meetings. Objective 2. Planting data was collected from the members of the Organic Arable Marketing Group in the first year of the project. Hereward and Claire were the most popular winter wheat varieties grown, and this was confirmed by a survey of the farmers involved in this project. A major concern of farmers was achieving milling quality specifications (especially protein concentration). Objective 3. Plots of three bread making winter wheat varieties (Hereward, Solstice and Xi19) and a mixture (1:1:1) of the varieties were grown at up to 19 UK farms in two seasons (2003/04 and 2004/05). Measurements were taken of growth habit, yield and grain quality. Grain yields in both seasons showed significant site by variety interactions, although the variation among sites was greater than among varieties in both instances. Wheat grown at Western sites was significantly shorter and higher-yielding than that grown at Eastern sites in 2003/04 but significantly taller in 2004/05. As with grain yield, greater variation among sites than varieties was found in the Hagberg Falling Number and protein concentration results in both seasons. The results from the two years of trials illustrate the variability of organic systems and the difficulty in selecting a single wheat variety suitable for organic farms. Garlic oil was used as a seed treatment for Hereward on two of the sites in the second year of trials. However, the treatment had no effect on establishment of the variety, and yields were variable. Benchmarking data was collected from 24 farms. Exsept appeared to be the highest yielding variety and yields varied with soil type (silts>clays>sands). More data would be needed to give an accurate picture of organic yields across the country. Objective 4. A total of 676 samples were tested between 2002 and 2005. Treatment thresholds for wheat seed have recently been extensively investigated and revised, producing a safe level below which untreated seed could be sown. Results showed that most samples had higher health status than the conventional treatment thresholds. However, there were occasional problems, most notably in the case of bunt on wheat, where very high levels of infection were seen, and the seed would have been unsuitable for further multiplication as seed, or for ware production. It was not possible to relate these occurrences consistently with any particular farm practice, with the possible exception of one site where minimum tillage was used, and the crop was always a second wheat. Ergot (Claviceps purpurea) was present at high levels (e.g. over 50 pieces per kg of seed) in several samples, but ergot infestation has also been increasing in frequency and severity in conventional production recently. Microdochium nivale sometimes reached high levels on wheat seed in seasons favourable to the disease, but similar levels were also seen in conventional samples received for testing at NIAB. Objective 5. Tests on appropriate varieties were carried out in 2 years. Of the wheat varieties: Hereward and Solstice appeared to show ‘resistance’ to bunt although the nature of the resistance is not known; Exsept, was consistently more resistant to Microdochium in the ear than other varieties; and Claire, Deben and Nijinsky appeared to be more resistant to loose smut than other varieties. There has been little effort to breed for seed borne disease resistance but these results indicate that it should be possible to introduce resistance, especially for diseases like loose smut. Objective 6. Seed treatment trials were carried out in 2004 and 2005 and comprised examples of biological, micronutrient and physical treatments. None of the treatments used in 2004 significantly improved establishment when wheat seed had a high level (30%) of Microdochium nivale seedling blight, and none significantly increased final yield. In 2005, one of the biological treatments tested (from Crompton Ltd) did significantly improve plant establishment, though effects on yield were non-significant. Both biological products (Cerall and the Crompton product) suppressed bunt in 2005, as did Radiate (ammonium and zinc ammonium complex), though the latter had no significant effect in 2004. The hot air treatment also reduced bunt in 2005, though the effect was less marked in 2004. Seed cleaning was also investigated as a means of improving establishment in Microdochium infected wheat. Though establishment counts and early spring counts were improved slightly in the cleaned seed compared to uncleaned, effects were not significant, and final yields were not improved. Incidence of disease in the cleaned versus uncleaned seed (% infection on agar plates) was similar, indicating that the process, although removing light and shrivelled seed, did not selectively remove infected seed. Objective 7. The code of best practice for seed production concentrated on bunt since this was the most prevalent problem found in this project. Guidelines included: always test untreated ‘mother’ seed; seed destined for further multiplication should have as close to 0 bunt spores/seed as possible; seed for crop production should have no more than 1 bunt spore/seed; grow farm-saved seed as first wheat; and sow wheat early to minimize any chances of infection. Objective 8. The participatory process was assessed three times using interviews with farmers and researchers involved in the project. It was evident that farmer participatory research was more complicated, time-consuming and expensive than expected. Key issues identified included: • Acknowledging and addressing the training needs of farmers and researchers at the outset of a project • Building a team of people (farmers and researchers) who understand each others’ background, and are able to work together towards an agreed set of goals. • Appreciating the commitment farmers must make on top of their existing workloads to engage in this sort of activity, and doing what is possible to facilitate this. • Identifying appropriate people to act as boundary spanners and draw all stakeholders together in dialogue. • Within this framework, identifying research goals that can be realistically met by all concerned. • A short leaflet and a longer document were produced for farmers/researchers setting out what’s involved in participatory research and the pros and cons of participating. Conclusions. The experimental aspect of this project has highlighted the large variation among organic systems and the problems in recommending a single variety to organic farmers. However, the work has shown that there are few problems in the health of the seed used in organic systems. This is particularly important since none of the potential organic seed treatments tested had a positive effect on yield. The main aspect of this work has been a learning experience in aspects of farmer participatory research in a UK context. Differing views have meant that natural and social scientists have written different parts of the discussion. Researchers have experienced difficulties in engaging farmers and managing their expectations, the challenges of working in multidisciplinary teams spread over different institutions and the extra time needed to build and maintain relationships. Farmer participatory research does have an important role to play in producing both relevant and rigorous results for farmers and funders. It has to be managed appropriately, and has to be recognised that processes are very different to a typical research project