Spartan Daily, May 17, 2004

Volume 122, Issue 69https://scholarworks.sjsu.edu/spartandaily/10003/thumbnail.jp

Spartan Daily, November 23, 2004

Volume 123, Issue 60https://scholarworks.sjsu.edu/spartandaily/10064/thumbnail.jp

Spartan Daily, May 16, 2005

Volume 124, Issue 70https://scholarworks.sjsu.edu/spartandaily/10142/thumbnail.jp

Spartan Daily, November 8, 2004

Volume 123, Issue 49https://scholarworks.sjsu.edu/spartandaily/10053/thumbnail.jp

Spartan Daily, October 4, 2004

Volume 123, Issue 25https://scholarworks.sjsu.edu/spartandaily/10029/thumbnail.jp

Combined therapies of antithrombotics and antioxidants delay in silico brain tumor progression

Glioblastoma multiforme, the most frequent type of primary brain tumor, is a rapidly evolving and spatially heterogeneous high-grade astrocytoma that presents areas of necrosis, hypercellularity and microvascular hyperplasia. The aberrant vasculature leads to hypoxic areas and results in an increase of the oxidative stress selecting for more invasive tumor cell phenotypes. In our study we assay in silico different therapeutic approaches which combine antithrombotics, antioxidants and standard radiotherapy. To do so, we have developed a biocomputational model of glioblastoma multiforme that incorporates the spatio-temporal interplay among two glioma cell phenotypes corresponding to oxygenated and hypoxic cells, a necrotic core and the local vasculature whose response evolves with tumor progression. Our numerical simulations predict that suitable combinations of antithrombotics and antioxidants may diminish, in a synergetic way, oxidative stress and the subsequent hypoxic response. This novel therapeutical strategy, with potentially low or no toxicity, might reduce tumor invasion and further sensitize glioblastoma multiforme to conventional radiotherapy or other cytotoxic agents, hopefully increasing median patient overall survival time.Comment: 8 figure

Spartan Daily, October 14, 2002

Volume 119, Issue 32https://scholarworks.sjsu.edu/spartandaily/10676/thumbnail.jp

Spartan Daily, December 8, 2004

Volume 123, Issue 67https://scholarworks.sjsu.edu/spartandaily/10071/thumbnail.jp

Spartan Daily, February 7, 2003

Volume 120, Issue 11https://scholarworks.sjsu.edu/spartandaily/9807/thumbnail.jp