Robust filtering for stochastic genetic regulatory networks with time-varying delay

This is the post print version of the article. The official published version can be obtained from the link - Copyright 2009 Elsevier LtdThis paper addresses the robust filtering problem for a class of linear genetic regulatory networks (GRNs) with stochastic disturbances, parameter uncertainties and time delays. The parameter uncertainties are assumed to reside in a polytopic region, the stochastic disturbance is state-dependent described by a scalar Brownian motion, and the time-varying delays enter into both the translation process and the feedback regulation process. We aim to estimate the true concentrations of mRNA and protein by designing a linear filter such that, for all admissible time delays, stochastic disturbances as well as polytopic uncertainties, the augmented state estimation dynamics is exponentially mean square stable with an expected decay rate. A delay-dependent linear matrix inequality (LMI) approach is first developed to derive sufficient conditions that guarantee the exponential stability of the augmented dynamics, and then the filter gains are parameterized in terms of the solution to a set of LMIs. Note that LMIs can be easily solved by using standard software packages. A simulation example is exploited in order to illustrate the effectiveness of the proposed design procedures.This work was supported in part by the Biotechnology and Biological Sciences Research Council (BBSRC) of the U.K. under Grants BB/C506264/1 and 100/EGM17735, an International Joint Project sponsored by the Royal Society of the U.K., the Research Grants Council of Hong Kong under Grant HKU 7031/06P, the National Natural Science Foundation of China under Grant 60804028, and the Alexander von Humboldt Foundation of Germany

Time-and event-driven communication process for networked control systems: A survey

Copyright © 2014 Lei Zou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.In recent years, theoretical and practical research topics on networked control systems (NCSs) have gained an increasing interest from many researchers in a variety of disciplines owing to the extensive applications of NCSs in practice. In particular, an urgent need has arisen to understand the effects of communication processes on system performances. Sampling and protocol are two fundamental aspects of a communication process which have attracted a great deal of research attention. Most research focus has been on the analysis and control of dynamical behaviors under certain sampling procedures and communication protocols. In this paper, we aim to survey some recent advances on the analysis and synthesis issues of NCSs with different sampling procedures (time-and event-driven sampling) and protocols (static and dynamic protocols). First, these sampling procedures and protocols are introduced in detail according to their engineering backgrounds as well as dynamic natures. Then, the developments of the stabilization, control, and filtering problems are systematically reviewed and discussed in great detail. Finally, we conclude the paper by outlining future research challenges for analysis and synthesis problems of NCSs with different communication processes.This work was supported in part by the National Natural Science Foundation of China under Grants 61329301, 61374127, and 61374010, the Royal Society of the UK, and the Alexander von Humboldt Foundation of Germany

Stability Analysis of Delayed Genetic Regulatory Networks via a Relaxed Double Integral Inequality

Time delay arising in a genetic regulatory network may cause the instability. This paper is concerned with the stability analysis of genetic regulatory networks with interval time-varying delays. Firstly, a relaxed double integral inequality, named as Wirtinger-type double integral inequality (WTDII), is established to estimate the double integral term appearing in the derivative of Lyapunov-Krasovskii functional with a triple integral term. And it is proved theoretically that the proposed WTDII is tighter than the widely used Jensen-based double inequality and the recently developed Wiringter-based double inequality. Then, by applying the WTDII to the stability analysis of a delayed genetic regulatory network, together with the usage of useful information of regulatory functions, several delay-range- and delay-rate-dependent (or delay-rate-independent) criteria are derived in terms of linear matrix inequalities. Finally, an example is carried out to verify the effectiveness of the proposed method and also to show the advantages of the established stability criteria through the comparison with some literature

Robust H∞ feedback control for uncertain stochastic delayed genetic regulatory networks with additive and multiplicative noise

The official published version can found at the link below.Noises are ubiquitous in genetic regulatory networks (GRNs). Gene regulation is inherently a stochastic process because of intrinsic and extrinsic noises that cause kinetic parameter variations and basal rate disturbance. Time delays are usually inevitable due to different biochemical reactions in such GRNs. In this paper, a delayed stochastic model with additive and multiplicative noises is utilized to describe stochastic GRNs. A feedback gene controller design scheme is proposed to guarantee that the GRN is mean-square asymptotically stable with noise attenuation, where the structure of the controllers can be specified according to engineering requirements. By applying control theory and mathematical tools, the analytical solution to the control design problem is given, which helps to provide some insight into synthetic biology and systems biology. The control scheme is employed in a three-gene network to illustrate the applicability and usefulness of the design.This work was funded by Royal Society of the U.K.; Foundation for the Author of National Excellent Doctoral Dissertation of China. Grant Number: 2007E4; Heilongjiang Outstanding Youth Science Fund of China. Grant Number: JC200809; Fok Ying Tung Education Foundation. Grant Number: 111064; International Science and Technology Cooperation Project of China. Grant Number: 2009DFA32050; University of Science and Technology of China Graduate Innovative Foundation

Finite-Time Stability Analysis of Switched Genetic Regulatory Networks

This paper investigates the finite-time stability problem of switching genetic regulatory networks (GRNs) with interval time-varying delays and unbounded continuous distributed delays. Based on the piecewise Lyapunov-Krasovskii functional and the average dwell time method, some new finite-time stability criteria are obtained in the form of linear matrix inequalities (LMIs), which are easy to be confirmed by the Matlab toolbox. The finite-time stability is taken into account in switching genetic regulatory networks for the first time and the average dwell time of the switching signal is obtained. Two numerical examples are presented to illustrate the effectiveness of our results

New Stability Criterion for Discrete-Time Genetic Regulatory Networks with Time-Varying Delays and Stochastic Disturbances

We propose an improved stability condition for a class of discrete-time genetic regulatory networks (GRNs) with interval time-varying delays and stochastic disturbances. By choosing an augmented novel Lyapunov-Krasovskii functional which contains some triple summation terms, a less conservative sufficient condition is obtained in terms of linear matrix inequalities (LMIs) by using the combination of the lower bound lemma, the discrete-time Jensen inequality, and the free-weighting matrix method. It is shown that the proposed results can be readily solved by using the Matlab software. Finally, two numerical examples are provided to illustrate the effectiveness and advantages of the theoretical results

An advanced delay-dependent approach of impulsive genetic regulatory networks besides the distributed delays, parameter uncertainties and time-varying delays

In this typescript, we concerned the problem of delay-dependent approach of impulsive genetic regulatory networks besides the distributed delays, parameter uncertainties and time-varying delays. An advanced Lyapunov–Krasovskii functional are defined, which is in triple integral form. Combining the Lyapunov–Krasovskii functional with convex combination method and free-weighting matrix approach the stability conditions are derived with the help of linear matrix inequalities (LMIs). Some available software collections are used to solve the conditions. Lastly, two numerical examples and their simulations are conferred to indicate the feasibility of the theoretical concepts

Stability and dissipativity analysis of static neural networks with time delay

This paper is concerned with the problems of stability and dissipativity analysis for static neural networks (NNs) with time delay. Some improved delay-dependent stability criteria are established for static NNs with time-varying or time-invariant delay using the delay partitioning technique. Based on these criteria, several delay-dependent sufficient conditions are given to guarantee the dissipativity of static NNs with time delay. All the given results in this paper are not only dependent upon the time delay but also upon the number of delay partitions. Some examples are given to illustrate the effectiveness and reduced conservatism of the proposed results.published_or_final_versio

A Less Conservative Stability Criterion for Delayed Stochastic Genetic Regulatory Networks

This paper concerns the problem of stability analysis for delayed stochastic genetic regulatory networks. By introducing an appropriate Lyapunov-Krasovskii functional and employing delay-range partition approach, a new stability criterion is given to ensure the mean square stability of genetic regulatory networks with time-varying delays and stochastic disturbances. The stability criterion is given in the form of linear matrix inequalities, which can be easily tested by the LMI Toolbox of MATLAB. Moreover, it is theoretically shown that the obtained stability criterion is less conservative than the one in W. Zhang et al., 2012. Finally, a numerical example is presented to illustrate our theory