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The Properties of Outer Retinal Band Three Investigated With Adaptive-Optics Optical Coherence Tomography.
PurposeOptical coherence tomography's (OCT) third outer retinal band has been attributed to the zone of interdigitation between RPE cells and cone outer segments. The purpose of this paper is to investigate the structure of this band with adaptive optics (AO)-OCT.MethodsUsing AO-OCT, images were obtained from two subjects. Axial structure was characterized by measuring band 3 thickness and separation between bands 2 and 3 in segmented cones. Lateral structure was characterized by correlation of band 3 with band 2 and comparison of their power spectra. Band thickness and separation were also measured in a clinical OCT image of one subject.ResultsBand 3 thickness ranged from 4.3 to 6.4 μm. Band 2 correlations ranged between 0.35 and 0.41 and power spectra of both bands confirmed peak frequencies that agree with histologic density measurements. In clinical images, band 3 thickness was between 14 and 19 μm. Measurements of AO-OCT of interband distance were lower than our corresponding clinical OCT measurements.ConclusionsBand 3 originates from a structure with axial extent similar to a single surface. Correlation with band 2 suggests an origin within the cone photoreceptor. These two observations indicate that band 3 corresponds predominantly to cone outer segment tips (COST). Conventional OCT may overestimate both the thickness of band 3 and outer segment length
Thermophysical Phenomena in Metal Additive Manufacturing by Selective Laser Melting: Fundamentals, Modeling, Simulation and Experimentation
Among the many additive manufacturing (AM) processes for metallic materials,
selective laser melting (SLM) is arguably the most versatile in terms of its
potential to realize complex geometries along with tailored microstructure.
However, the complexity of the SLM process, and the need for predictive
relation of powder and process parameters to the part properties, demands
further development of computational and experimental methods. This review
addresses the fundamental physical phenomena of SLM, with a special emphasis on
the associated thermal behavior. Simulation and experimental methods are
discussed according to three primary categories. First, macroscopic approaches
aim to answer questions at the component level and consider for example the
determination of residual stresses or dimensional distortion effects prevalent
in SLM. Second, mesoscopic approaches focus on the detection of defects such as
excessive surface roughness, residual porosity or inclusions that occur at the
mesoscopic length scale of individual powder particles. Third, microscopic
approaches investigate the metallurgical microstructure evolution resulting
from the high temperature gradients and extreme heating and cooling rates
induced by the SLM process. Consideration of physical phenomena on all of these
three length scales is mandatory to establish the understanding needed to
realize high part quality in many applications, and to fully exploit the
potential of SLM and related metal AM processes
Predictability: a way to characterize Complexity
Different aspects of the predictability problem in dynamical systems are
reviewed. The deep relation among Lyapunov exponents, Kolmogorov-Sinai entropy,
Shannon entropy and algorithmic complexity is discussed. In particular, we
emphasize how a characterization of the unpredictability of a system gives a
measure of its complexity. Adopting this point of view, we review some
developments in the characterization of the predictability of systems showing
different kind of complexity: from low-dimensional systems to high-dimensional
ones with spatio-temporal chaos and to fully developed turbulence. A special
attention is devoted to finite-time and finite-resolution effects on
predictability, which can be accounted with suitable generalization of the
standard indicators. The problems involved in systems with intrinsic randomness
is discussed, with emphasis on the important problems of distinguishing chaos
from noise and of modeling the system. The characterization of irregular
behavior in systems with discrete phase space is also considered.Comment: 142 Latex pgs. 41 included eps figures, submitted to Physics Reports.
Related information at this http://axtnt2.phys.uniroma1.i
Three-dimensional distribution of primary melt inclusions in garnets by X-ray microtomography
open6X-ray computed microtomography (X-mu CT) is applied here to investigate in a non-invasive way the three-dimensional (3D) spatial distribution of primary melt and fluid inclusions in gamets from the metapeitic enclaves of El Hoyazo and from the migmatitcs of Sierra Alpujata, Spain. Attention is focused on a particular case of inhomogeneous distribution of inclusions, characterized by inclusion-rich cores and almost inclusion-free rims (i.e., zonal arrangement), that has been previously investigated in detail only by means of 2D conventional methods. Different experimental X-mu CT configurations, both synchrotron radiation- and X-ray tube-based, are employed to explore the limits of the technique. The internal features of the samples are successfully imaged, with spatial resolution down to a few micrometers.
By means of dedicated image processing protocols, the lighter melt and fluid inclusions can be separated from the heavier host garnet and from other non-relevant features (e.g., other mineral phases or large voids). This allows evaluating the volumetric density of inclusions within spherical shells as a function of the radial distance from the center of the host garnets. The 3D spatial distribution of heavy mineral inclusions is investigated as well and compared with that of melt inclusions.
Data analysis reveals the occurrence of a clear peak of melt and fluid inclusions density, ranging approximately from 1/3 to 1/2 of the radial distance from the center of the distribution and a gradual decrease from the peak outward. heavy mineral inclusions appear to be almost absent in the central portion of the garnets and more randomly arranged, showing no correlation with the distribution of melt and fluid inclusions. To reduce the effect of geometric artifacts arising from the non-spherical shape of the distribution, the inclusion density was calculated also along narrow prisms with different orientations, obtaining plots of pseudo-linear distributions. The results show that the core-rim transition is characterized by a rapid (but not step-like) decrease in inclusion density, occurring in a continuous mode. X-ray tomographic data, combined with electron microprobe chemical profiles of selected elements, suggest that despite the inhomogeneous distribution of inclusions, the investigated garnets have grown in one single progressive episode in the presence of anatectic melt. The continuous drop of inclusion density suggests a similar decline in (radial) garnet growth, which is a natural consequence in the case of a constant reaction rate.
Our results confirm the advantages of high-resolution X-mu CT compared to conventional destructive 2D observations for the analysis of the spatial distribution of micrometer-scale inclusions in minerals, owing to its non-invasive 3D capabilities. The same approach can be extended to the study of different microstructural features in samples from a wide variety of geological settings.openParisatto, Matteo; Turina, Alice; Cruciani, Giuseppe; Mancini, Lucia; Peruzzo, Luca; Cesare, BernardoParisatto, Matteo; Turina, Alice; Cruciani, Giuseppe; Mancini, Lucia; Peruzzo, Luca; Cesare, Bernard
Minkowski Tensors of Anisotropic Spatial Structure
This article describes the theoretical foundation of and explicit algorithms
for a novel approach to morphology and anisotropy analysis of complex spatial
structure using tensor-valued Minkowski functionals, the so-called Minkowski
tensors. Minkowski tensors are generalisations of the well-known scalar
Minkowski functionals and are explicitly sensitive to anisotropic aspects of
morphology, relevant for example for elastic moduli or permeability of
microstructured materials. Here we derive explicit linear-time algorithms to
compute these tensorial measures for three-dimensional shapes. These apply to
representations of any object that can be represented by a triangulation of its
bounding surface; their application is illustrated for the polyhedral Voronoi
cellular complexes of jammed sphere configurations, and for triangulations of a
biopolymer fibre network obtained by confocal microscopy. The article further
bridges the substantial notational and conceptual gap between the different but
equivalent approaches to scalar or tensorial Minkowski functionals in
mathematics and in physics, hence making the mathematical measure theoretic
method more readily accessible for future application in the physical sciences
High Resolution Microimaging with Pulsed Electrically-Detected Magnetic Resonance
The investigation of paramagnetic species (such as point defects, dopants,
and impurities) in solid-state electronic devices is significant because of
their effect on device performance. Conventionally, these species are detected
and imaged using the electron spin resonance (ESR) technique. In many
instances, ESR is not sensitive enough to deal with miniature devices having
small numbers of paramagnetic species and high spatial heterogeneity. This
limitation can in principle be overcome by employing a more sensitive method
called electrically-detected magnetic resonance, which is based on measuring
the effect of paramagnetic species on the electric current of the device while
inducing electron spin-flip transitions. However, up until now, measurement of
the current of the device could not reveal the spatial heterogeneity of its
paramagnetic species. We provide here, for the first time, high resolution
microimages of paramagnetic species in operating solar cells obtained through
electrically-detected magnetic resonance. The method is based on unique
microwave pulse sequences for excitation and detection of the electrical signal
under a static magnetic field and powerful pulsed magnetic field gradients that
spatially encode the electrical current of the sample. The approach developed
here can be widely used in the nondestructive three-dimensional inspection and
characterization of paramagnetic species in a variety of electronic devices.Comment: 19 pages, 4 figures +S
Cell Detection by Functional Inverse Diffusion and Non-negative Group SparsityPart I: Modeling and Inverse Problems
In this two-part paper, we present a novel framework and methodology to
analyze data from certain image-based biochemical assays, e.g., ELISPOT and
Fluorospot assays. In this first part, we start by presenting a physical
partial differential equations (PDE) model up to image acquisition for these
biochemical assays. Then, we use the PDEs' Green function to derive a novel
parametrization of the acquired images. This parametrization allows us to
propose a functional optimization problem to address inverse diffusion. In
particular, we propose a non-negative group-sparsity regularized optimization
problem with the goal of localizing and characterizing the biological cells
involved in the said assays. We continue by proposing a suitable discretization
scheme that enables both the generation of synthetic data and implementable
algorithms to address inverse diffusion. We end Part I by providing a
preliminary comparison between the results of our methodology and an expert
human labeler on real data. Part II is devoted to providing an accelerated
proximal gradient algorithm to solve the proposed problem and to the empirical
validation of our methodology.Comment: published, 15 page
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