Sensitivity Analysis for Unmeasured Confounding in Meta-Analyses

Random-effects meta-analyses of observational studies can produce biased estimates if the synthesized studies are subject to unmeasured confounding. We propose sensitivity analyses quantifying the extent to which unmeasured confounding of specified magnitude could reduce to below a certain threshold the proportion of true effect sizes that are scientifically meaningful. We also develop converse methods to estimate the strength of confounding capable of reducing the proportion of scientifically meaningful true effects to below a chosen threshold. These methods apply when a "bias factor" is assumed to be normally distributed across studies or is assessed across a range of fixed values. Our estimators are derived using recently proposed sharp bounds on confounding bias within a single study that do not make assumptions regarding the unmeasured confounders themselves or the functional form of their relationships to the exposure and outcome of interest. We provide an R package, ConfoundedMeta, and a freely available online graphical user interface that compute point estimates and inference and produce plots for conducting such sensitivity analyses. These methods facilitate principled use of random-effects meta-analyses of observational studies to assess the strength of causal evidence for a hypothesis

Actors and factors - bridging social science findings and urban land use change modeling

Recent uneven land use dynamics in urban areas resulting from demographic change, economic pressure and the cities’ mutual competition in a globalising world challenge both scientists and practitioners, among them social scientists, modellers and spatial planners. Processes of growth and decline specifically affect the urban environment, the requirements of the residents on social and natural resources. Social and environmental research is interested in a better understanding and ways of explaining the interactions between society and landscape in urban areas. And it is also needed for making life in cities attractive, secure and affordable within or despite of uneven dynamics.\ud The position paper upon “Actors and factors – bridging social science findings and urban land use change modeling” presents approaches and ideas on how social science findings on the interaction of the social system (actors) and the land use (factors) are taken up and formalised using modelling and gaming techniques. It should be understood as a first sketch compiling major challenges and proposing exemplary solutions in the field of interest

Education and Its Distributional Impacts on Living Standards

This paper investigates the determinants of living standards (measured by per capita consumption expenditure) at the household level, addressing heterogeneity in returns to education and endogeneity of educational status. The estimation results obtained through an instrumental variables quantile regression suggest that the endogeneity of education matters in determining the causal effect of education on living standards, while no evidence of the heterogeneity in the rate of returns to education is found. However, the results also provide evidence that impacts of other determinants vary significantly over the outcome (expenditure) distribution, and consequently a simulation based on the results shows that poverty alleviation impacts of education differs substantially between the instrumental variables quantile regression and standard instrumental variables regression results. The comparison of the two indicates the possibility that the impact on poverty reduction is likely to be overestimated in the standard instrumental variable regression.poverty, heterogeneous returns to education, instrumental variables quantile regression

Bayesian Model Selection in Complex Linear Systems, as Illustrated in Genetic Association Studies

Motivated by examples from genetic association studies, this paper considers the model selection problem in a general complex linear model system and in a Bayesian framework. We discuss formulating model selection problems and incorporating context-dependent {\it a priori} information through different levels of prior specifications. We also derive analytic Bayes factors and their approximations to facilitate model selection and discuss their theoretical and computational properties. We demonstrate our Bayesian approach based on an implemented Markov Chain Monte Carlo (MCMC) algorithm in simulations and a real data application of mapping tissue-specific eQTLs. Our novel results on Bayes factors provide a general framework to perform efficient model comparisons in complex linear model systems

A Bayesian space-time model for discrete spread processes on a lattice

Funding for this work was provided by GEOIDE through the Government of Canada’s Networks for Centres of Excellence program.In this article we present a Bayesian Markov model for investigating environmental spread processes. We formulate a model where the spread of a disease over a heterogeneous landscape through time is represented as a probabilistic function of two processes: local diffusion and random-jump dispersal. This formulation represents two mechanisms of spread which result in highly peaked and long-tailed distributions of dispersal distances (i.e., local and long-distance spread), commonly observed in the spread of infectious diseases and biological invasions. We demonstrate the properties of this model using a simulation experiment and an empirical case study - the spread of mountain pine beetle in western Canada. Posterior predictive checking was used to validate the number of newly inhabited regions in each time period. The model performed well in the simulation study in which a goodness-of-fit statistic measuring the number of newly inhabited regions in each time interval fell within the 95% posterior predictive credible interval in over 97% of simulations. The case study of a mountain pine beetle infestation in western Canada (1999-2009) extended the base model in two ways. First, spatial covariates thought to impact the local diffusion parameters, elevation and forest cover, were included in the model. Second, a refined definition for translocation or jump-dispersal based on mountain pine beetle ecology was incorporated improving the fit of the model. Posterior predictive checks on the mountain pine beetle model found that the observed goodness-of-fit test statistic fell within the 95% posterior predictive credible interval for 8 out of 10. years. The simulation study and case study provide evidence that the model presented here is both robust and flexible; and is therefore appropriate for a wide range of spread processes in epidemiology and ecology.PostprintPeer reviewe

Quantifying and Explaining Causal Effects of World Bank Aid Projects

In recent years, machine learning methods have enabled us to predict with good precision using large training data, such as deep learning. However, for many problems, we care more about causality than prediction. For example, instead of knowing that smoking is statistically associated with lung cancer, we are more interested in knowing that smoking is the cause of lung cancer. With causality, we can understand how the world progresses and how impacts are made on an outcome by influencing the cause. This thesis explores how to quantify the causal effects of a treatment on an observable outcome in the presence of heterogeneity. We focus on investigating the causal impacts that World Bank projects have on environmental changes. This high dimensional World Bank data set includes covariates from various sources and of different types, including time series data, such as the Normalized Difference Vegetation Index (NDVI) values, temperature and precipitation, spatial data such as longitude and latitude, and many other features such as distance to roads and rivers. We estimate the heterogeneous causal effect of World Bank projects on the change of NDVI values. Based on causal tree and causal forest proposed by Athey, we described the challenges we met and lessons we learned when applying these two methods to an actual World Bank data set. We show our observations of the heterogeneous causal effect of the World Bank projects on the change of environment. as we do not have the ground truth for the World Bank data set, we validate the results using synthetic data for simulation studies. The synthetic data is sampled from distributions fitted with the World Bank data set. We compared the results among various causal inference methods and observed that feature scaling is very important to generating meaningful data and results. in addition, we investigate the performance of the causal forest with various parameters such as leaf size, number of confounders, and data size. Causal forest is a black-box model, and the results from it cannot be easily interpreted. The results are also hard for humans to understand. By taking advantage of the tree structure, the neighbors of the project to be explained are selected. The weights are assigned to the neighbors according to dynamic distance metrics. We can learn a linear regression model with the neighbors and interpret the results with the help of the learned linear regression model. in summary, World Bank projects have small impacts on the change to the environment, and the result of an individual project can be interpreted using a linear regression model learned from closed projects