Robustness analysis of signaling transduction networks based on Monte-Carlo method

The dynamic behaviors of cell system were deep ly affected by structural complexity of cell signal transduction networks and uncertainty of kinetics parameters. How to quantitatively determinate the relation between system behaviors and parameters variations was an important p roblem of systems biology. In order to study robustness of NF - κB signal transduction networks, the parameters of system model were assigned to subject to stochastic distributions. Then, robustness of system output signal NF - κBn with respect to 64 parameters variations and amp litude variation of step input signal IKK was studied by means of Monte - Carlo method. The simulation results demonstrate that the oscillation behavior of system output signal NF - κBn is closely relative to 6 key rate constantswhose robustness isweak, and the amp litude variation of step input signal IKKmakes a great impact on the oscillation behavior of system output

Design of Simplified Maximum-Likelihood Receivers for Multiuser CPM Systems

A class of simplified maximum-likelihood receivers designed for continuous phase modulation based multiuser systems is proposed. The presented receiver is built upon a front end employing mismatched filters and a maximum-likelihood detector defined in a low-dimensional signal space. The performance of the proposed receivers is analyzed and compared to some existing receivers. Some schemes are designed to implement the proposed receivers and to reveal the roles of different system parameters. Analysis and numerical results show that the proposed receivers can approach the optimum multiuser receivers with significantly (even exponentially in some cases) reduced complexity and marginal performance degradation

Capacity-achieving CPM schemes

The pragmatic approach to coded continuous-phase modulation (CPM) is proposed as a capacity-achieving low-complexity alternative to the serially-concatenated CPM (SC-CPM) coding scheme. In this paper, we first perform a selection of the best spectrally-efficient CPM modulations to be embedded into SC-CPM schemes. Then, we consider the pragmatic capacity (a.k.a. BICM capacity) of CPM modulations and optimize it through a careful design of the mapping between input bits and CPM waveforms. The so obtained schemes are cascaded with an outer serially-concatenated convolutional code to form a pragmatic coded-modulation system. The resulting schemes exhibit performance very close to the CPM capacity without requiring iterations between the outer decoder and the CPM demodulator. As a result, the receiver exhibits reduced complexity and increased flexibility due to the separation of the demodulation and decoding functions.Comment: Submitted to IEEE Transactions on Information Theor

Advanced low-complexity multiuser receivers

It tema centrale di questa tesi è la rivelazione multi-utente per sistemi di comunicazione wireless ad elevata efficienza spettrale. Lo scopo del lavoro è quello di proporre nuovi ricevitori multi-utente a bassa complessità con elevate prestazioni. Sono considerati sistemi satellitari basati su FDM (Frequency Division Multiplexing), in cui ogni utente adotta una modulazione CPM (Continuous Phase Modulation) concatenata serialmente con un codificatore tramite un interlacciatore e decodifica iterativa. Si considerano, inoltre, canali lineari in presenza di AWGN (additive white Gaussian noise). In particolare, si studiano sistemi FDM, in cui i canali adiacenti possono sovrapporsi in frequenza per aumentere l'efficienza spettrale, e sistemi CDMA (code division multiple access). Per gli scenari presi in esame, proponiamo schemi di rivelazione con un eccellente compromesso tra prestazioni e complessità computazionale, che permettono di implementare schemi di trasmissione con straordinaria efficienza spettrale, al prezzo di un limitato aumento di complessità rispetto ad un classico ricevitore singolo-utente che ignora l'interferenza.This thesis deals with multiuser detection (MUD) for spectrally-efficient wireless communication systems. The aim of this work is to propose new advanced low-complexity multiuser receivers with near-optimal detection performance. We consider frequency division multiplexing (FDM) satellite systems where each user employs a continuous phase modulation (CPM), serially concatenated with an outer code through an interleaver, and iterative detection/decoding. We also consider linear channels impaired by additive white Gaussian noise (AWGN), focusing on FDM systems where adjacent channels are allowed to overlap in frequency, and on code division multiple access systems (CDMA). For the considered scenarios, we propose detection schemes with an excel- lent performance/complexity tradeoff which allow us to implement transmission schemes with unprecedented spectral efficiency at a price of a limited complexity increase with respect to a classical single-user receiver which neglects the interference

Capacity -based parameter optimization of bandwidth constrained CPM

Continuous phase modulation (CPM) is an attractive modulation choice for bandwidth limited systems due to its small side lobes, fast spectral decay and the ability to be noncoherently detected. Furthermore, the constant envelope property of CPM permits highly power efficient amplification. The design of bit-interleaved coded continuous phase modulation is characterized by the code rate, modulation order, modulation index, and pulse shape. This dissertation outlines a methodology for determining the optimal values of these parameters under bandwidth and receiver complexity constraints. The cost function used to drive the optimization is the information-theoretic minimum ratio of energy-per-bit to noise-spectral density found by evaluating the constrained channel capacity. The capacity can be reliably estimated using Monte Carlo integration. A search for optimal parameters is conducted over a range of coded CPM parameters, bandwidth efficiencies, and channels. Results are presented for a system employing a trellis-based coherent detector. To constrain complexity and allow any modulation index to be considered, a soft output differential phase detector has also been developed.;Building upon the capacity results, extrinsic information transfer (EXIT) charts are used to analyze a system that iterates between demodulation and decoding. Convergence thresholds are determined for the iterative system for different outer convolutional codes, alphabet sizes, modulation indices and constellation mappings. These are used to identify the code and modulation parameters with the best energy efficiency at different spectral efficiencies for the AWGN channel. Finally, bit error rate curves are presented to corroborate the capacity and EXIT chart designs

Study of continuous-phase four-state modulation for cordless telecommunications. Assessment by simulation of CP-QFSK as an alternative modulation scheme for TDMA digital cordless telecommunications systems operating in indoor applications

One of the major driving elements behind the explosive boom in wireless revolution is the advances in the field of modulation which plays a fundamental role in any communication system, and especially in cellular radio systems. Hence, the elaborate choice of an efficient modulation scheme is of paramount importance in the design and employment of any communications system. Work presented in this thesis is an investigation (study) of the feasibility of whether multilevel FSK modulation scheme would provide a viable alternative modem that can be employed in TDMA cordless communications systems. In the thesis the design and performance analysis of a non-coherent multi-level modem that offers a great deal of bandwidth efficiency and hardware simplicity is studied in detail. Simulation results demonstrate that 2RC pre-modulation filter pulse shaping with a modulation index of 0.3, and pre-detection filter normalized equivalent noise bandwidth of 1.5 are optimum system parameter values. Results reported in chapter 5 signify that an adjacent channel rejection factor of around 40 dB has been achieved at channel spacing of 1.5 times the symbol rate while the DECT system standards stipulated a much lower rejection limit criterion (25-30dB), implying that CP-QFSK modulation out-performs the conventional GMSK as it causes significantly less ACI, thus it is more spectrally efficient in a multi-channel system. However, measured system performance in terms of BER indicates that this system does not coexist well with other interferers as at delay spreads between 100ns to 200ns, which are commonly encountered in such indoor environment, a severe degradation in system performance apparently caused by multi-path fading has been noticed, and there exists a noise floor of about 40 dB, i.e. high irreducible error rate of less than 5.10-3. Implementing MRC diversity combiner and BCH codec has brought in a good gain.Higher Education Ministr