Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs

Searches for Gauge-Mediated Supersymmetry Breaking Topologies in e+e- collisions at LEP2

In gauge-mediated supersymmetry (SUSY) breaking (GMSB) models the lightest supersymmetric particle (LSP) is the gravitino and the phenomenology is driven by the nature of the next-to-lightest SUSY particle (NLSP) which is either the lightest neutralino, the stau or mass degenerate sleptons. Since the NLSP decay length is effectively unconstrained, searches for all possible lifetime and NLSP topologies predicted by GMSB models in e+e- collisions are performed on the data sample collected by OPAL at centre-of-mass energies up to 209 GeV at LEP. Results independent of the NLSP lifetime are presented for all relevant final states including direct NLSP pair-production and, for the first time, also NLSP production via cascade decays of heavier SUSY particles. None of the searches shows evidence for SUSY particle production. Cross-section limits are presented at the 95% confidence level both for direct NLSP production and for cascade decays, providing the most general, almost model independent results. These results are then interpreted in the framework of the minimal GMSB (mGMSB) model, where large areas of the accessible parameter space are excluded. In the mGMSB model, the NLSP masses are constrained to be larger than 53.5 GeV/c^2, 87.4 GeV/c^2 and 91.9 GeV/c^2 in the neutralino, stau and slepton co-NLSP scenarios, respectively. A complete scan on the parameters of the mGMSB model is performed, constraining the universal SUSY mass scale Lambda from the direct SUSY particle searches: Lambda > 40, 27, 21, 17, 15 TeV/c^2 for messenger indices N=1, 2, 3, 4, 5 respectively, for all NLSP lifetimes.Comment: 4 pages, 2 figures. To appear in Proceedings of SUSY06, the 14th International Conference on Supersymmetry and the Unification of Fundamental Interactions, UC Irvine, California, 12-17 June 200

On the use of blow up to study regularizations of singularities of piecewise smooth dynamical systems in R3\mathbb{R}^3

In this paper we use the blow up method of Dumortier and Roussarie \cite{dumortier_1991,dumortier_1993,dumortier_1996}, in the formulation due to Krupa and Szmolyan \cite{krupa_extending_2001}, to study the regularization of singularities of piecewise smooth dynamical systems \cite{filippov1988differential} in $\mathbb R^3$. Using the regularization method of Sotomayor and Teixeira \cite{Sotomayor96}, first we demonstrate the power of our approach by considering the case of a fold line. We quickly recover a main result of Bonet and Seara \cite{reves_regularization_2014} in a simple manner. Then, for the two-fold singularity, we show that the regularized system only fully retains the features of the singular canards in the piecewise smooth system in the cases when the sliding region does not include a full sector of singular canards. In particular, we show that every locally unique primary singular canard persists the regularizing perturbation. For the case of a sector of primary singular canards, we show that the regularized system contains a canard, provided a certain non-resonance condition holds. Finally, we provide numerical evidence for the existence of secondary canards near resonance.Comment: To appear in SIAM Journal of Applied Dynamical System

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far

Towards wafer scale inductive determination of magnetostatic and dynamic parameters of magnetic thin films and multilayers

We investigate an inductive probe head suitable for non-invasive characterization of the magnetostatic and dynamic parameters of magnetic thin films and multilayers on the wafer scale. The probe is based on a planar waveguide with rearward high frequency connectors that can be brought in close contact to the wafer surface. Inductive characterization of the magnetic material is carried out by vector network analyzer ferromagnetic resonance. Analysis of the field dispersion of the resonance allows the determination of key material parameters such as the saturation magnetization MS or the effective damping parameter Meff. Three waveguide designs are tested. The broadband frequency response is characterized and the suitability for inductive determination of MS and Meff is compared. Integration of such probes in a wafer prober could in the future allow wafer scale in-line testing of magnetostatic and dynamic key material parameters of magnetic thin films and multilayers

An End-to-End Conversational Style Matching Agent

We present an end-to-end voice-based conversational agent that is able to engage in naturalistic multi-turn dialogue and align with the interlocutor's conversational style. The system uses a series of deep neural network components for speech recognition, dialogue generation, prosodic analysis and speech synthesis to generate language and prosodic expression with qualities that match those of the user. We conducted a user study (N=30) in which participants talked with the agent for 15 to 20 minutes, resulting in over 8 hours of natural interaction data. Users with high consideration conversational styles reported the agent to be more trustworthy when it matched their conversational style. Whereas, users with high involvement conversational styles were indifferent. Finally, we provide design guidelines for multi-turn dialogue interactions using conversational style adaptation

The gamma-ray burst monitor for Lobster-ISS

Lobster-ISS is an X-ray all-sky monitor experiment selected by ESA two years ago for a Phase A study (now almost completed) for a future flight (2009) aboard the Columbus Exposed Payload Facility of the International Space Station. The main instrument, based on MCP optics with Lobster-eye geometry, has an energy passband from 0.1 to 3.5 keV, an unprecedented daily sensitivity of 2x10^{-12} erg cm^{-2}s$^{-1}, and it is capable to scan, during each orbit, the entire sky with an angular resolution of 4--6 arcmin. This X-ray telescope is flanked by a Gamma Ray Burst Monitor, with the minimum requirement of recognizing true GRBs from other transient events. In this paper we describe the GRBM. In addition to the minimum requirement, the instrument proposed is capable to roughly localize GRBs which occur in the Lobster FOV (162x22.5 degrees) and to significantly extend the scientific capabilities of the main instrument for the study of GRBs and X-ray transients. The combination of the two instruments will allow an unprecedented spectral coverage (from 0.1 up to 300/700 keV) for a sensitive study of the GRB prompt emission in the passband where GRBs and X-Ray Flashes emit most of their energy. The low-energy spectral band (0.1-10 keV) is of key importance for the study of the GRB environment and the search of transient absorption and emission features from GRBs, both goals being crucial for unveiling the GRB phenomenon. The entire energy band of Lobster-ISS is not covered by either the Swift satellite or other GRB missions foreseen in the next decade.Comment: 6 pages, 4 figures. Paper presented at the COSPAR 2004 General Assembly (Paris), accepted for publication in Advances in Space Research in June 2005 and available on-line at the Journal site (http://www.sciencedirect.com/science/journal/02731177), section "Articles in press

Thermodynamical properties of the ICM from hydrodynamical simulations

Modern hydrodynamical simulations offer nowadays a powerful means to trace the evolution of the X-ray properties of the intra-cluster medium (ICM) during the cosmological history of the hierarchical build up of galaxy clusters. In this paper we review the current status of these simulations and how their predictions fare in reproducing the most recent X-ray observations of clusters. After briefly discussing the shortcomings of the self-similar model, based on assuming that gravity only drives the evolution of the ICM, we discuss how the processes of gas cooling and non-gravitational heating are expected to bring model predictions into better agreement with observational data. We then present results from the hydrodynamical simulations, performed by different groups, and how they compare with observational data. As terms of comparison, we use X-ray scaling relations between mass, luminosity, temperature and pressure, as well as the profiles of temperature and entropy. The results of this comparison can be summarised as follows: (a) simulations, which include gas cooling, star formation and supernova feedback, are generally successful in reproducing the X-ray properties of the ICM outside the core regions; (b) simulations generally fail in reproducing the observed ``cool core'' structure, in that they have serious difficulties in regulating overcooling, thereby producing steep negative central temperature profiles. This discrepancy calls for the need of introducing other physical processes, such as energy feedback from active galactic nuclei, which should compensate the radiative losses of the gas with high density, low entropy and short cooling time, which is observed to reside in the innermost regions of galaxy clusters.Comment: 26 pages, 12 figures, accepted for publication in Space Science Reviews, special issue "Clusters of galaxies: beyond the thermal view", Editor J.S. Kaastra, Chapter 13; work done by an international team at the International Space Science Institute (ISSI), Bern, organised by J.S. Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke