Current Trend of Off-Pump Coronary Artery Bypass Grafting

Published in Front Lines of Thoracic Surgery , Edited by Stefano Nazari, ISBN 978-953-307-915-8, Published: February 3, 2012 under CC BY 3.0 license Coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) and cardioplegic arrest has been performed safely over several decades. Cardiac surgery under cardiac arrest provides a bloodless stable operative field, that can facilitate anastomosis. In last decade, CABG without CPB, off-pump CABG (OPCAB) has become more common with advances in surgical instruments and technique. This chapter summarizes the surgical technique, risks and benefits of OPCAB

Stereoscopic Sketchpad: 3D Digital Ink

--Context-- This project looked at the development of a stereoscopic 3D environment in which a user is able to draw freely in all three dimensions. The main focus was on the storage and manipulation of the ‘digital ink’ with which the user draws. For a drawing and sketching package to be effective it must not only have an easy to use user interface, it must be able to handle all input data quickly and efficiently so that the user is able to focus fully on their drawing. --Background-- When it comes to sketching in three dimensions the majority of applications currently available rely on vector based drawing methods. This is primarily because the applications are designed to take a users two dimensional input and transform this into a three dimensional model. Having the sketch represented as vectors makes it simpler for the program to act upon its geometry and thus convert it to a model. There are a number of methods to achieve this aim including Gesture Based Modelling, Reconstruction and Blobby Inflation. Other vector based applications focus on the creation of curves allowing the user to draw within or on existing 3D models. They also allow the user to create wire frame type models. These stroke based applications bring the user closer to traditional sketching rather than the more structured modelling methods detailed. While at present the field is inundated with vector based applications mainly focused upon sketch-based modelling there are significantly less voxel based applications. The majority of these applications focus on the deformation and sculpting of voxmaps, almost the opposite of drawing and sketching, and the creation of three dimensional voxmaps from standard two dimensional pixmaps. How to actually sketch freely within a scene represented by a voxmap has rarely been explored. This comes as a surprise when so many of the standard 2D drawing programs in use today are pixel based. --Method-- As part of this project a simple three dimensional drawing program was designed and implemented using C and C++. This tool is known as Sketch3D and was created using a Model View Controller (MVC) architecture. Due to the modular nature of Sketch3Ds system architecture it is possible to plug a range of different data structures into the program to represent the ink in a variety of ways. A series of data structures have been implemented and were tested for efficiency. These structures were a simple list, a 3D array, and an octree. They have been tested for: the time it takes to insert or remove points from the structure; how easy it is to manipulate points once they are stored; and also how the number of points stored effects the draw and rendering times. One of the key issues brought up by this project was devising a means by which a user is able to draw in three dimensions while using only two dimensional input devices. The method settled upon and implemented involves using the mouse or a digital pen to sketch as one would in a standard 2D drawing package but also linking the up and down keyboard keys to the current depth. This allows the user to move in and out of the scene as they draw. A couple of user interface tools were also developed to assist the user. A 3D cursor was implemented and also a toggle, which when on, highlights all of the points intersecting the depth plane on which the cursor currently resides. These tools allow the user to see exactly where they are drawing in relation to previously drawn lines. --Results-- The tests conducted on the data structures clearly revealed that the octree was the most effective data structure. While not the most efficient in every area, it manages to avoid the major pitfalls of the other structures. The list was extremely quick to render and draw to the screen but suffered severely when it comes to finding and manipulating points already stored. In contrast the three dimensional array was able to erase or manipulate points effectively while the draw time rendered the structure effectively useless, taking huge amounts of time to draw each frame. The focus of this research was on how a 3D sketching package would go about storing and accessing the digital ink. This is just a basis for further research in this area and many issues touched upon in this paper will require a more in depth analysis. The primary area of this future research would be the creation of an effective user interface and the introduction of regular sketching package features such as the saving and loading of images

Visual pattern recognition using neural networks

Neural networks have been widely studied in a number of fields, such as neural architectures, neurobiology, statistics of neural network and pattern classification. In the field of pattern classification, neural network models are applied on numerous applications, for instance, character recognition, speech recognition, and object recognition. Among these, character recognition is commonly used to illustrate the feature and classification characteristics of neural networks. In this dissertation, the theoretical foundations of artificial neural networks are first reviewed and existing neural models are studied. The Adaptive Resonance Theory (ART) model is improved to achieve more reasonable classification results. Experiments in applying the improved model to image enhancement and printed character recognition are discussed and analyzed. We also study the theoretical foundation of Neocognitron in terms of feature extraction, convergence in training, and shift invariance. We investigate the use of multilayered perceptrons with recurrent connections as the general purpose modules for image operations in parallel architectures. The networks are trained to carry out classification rules in image transformation. The training patterns can be derived from user-defmed transformations or from loading the pair of a sample image and its target image when the prior knowledge of transformations is unknown. Applications of our model include image smoothing, enhancement, edge detection, noise removal, morphological operations, image filtering, etc. With a number of stages stacked up together we are able to apply a series of operations on the image. That is, by providing various sets of training patterns the system can adapt itself to the concatenated transformation. We also discuss and experiment in applying existing neural models, such as multilayered perceptron, to realize morphological operations and other commonly used imaging operations. Some new neural architectures and training algorithms for the implementation of morphological operations are designed and analyzed. The algorithms are proven correct and efficient. The proposed morphological neural architectures are applied to construct the feature extraction module of a personal handwritten character recognition system. The system was trained and tested with scanned image of handwritten characters. The feasibility and efficiency are discussed along with the experimental results

NASA/MSFC Large Stretch Press Study

The purpose of this study was to: A. assess and document the advantages/disadvantages of a government agency investment in a large stretch form press on the order of 5000 tons capacity (per jaw); B. develop a procurement specification for the press; and C. provide trade study data that will permit an optimum site location. Tasks were separated into four major elements: cost study, user survey, site selection, and press design/procurement specification

Requirements for a lead compound to become a clinical candidate

A drug candidate suitable for clinical testing is expected to bind selectively to the receptor site on the target, to elicit the desired functional response of the target molecule, and to have adequate bioavailability and biodistribution to elicit the desired responses in animals and humans; it must also pass formal toxicity evaluation in animals. The path from lead to clinical drug candidate represents the most idiosyncratic segment of drug discovery and development. Each program is unique and setbacks are common, making it difficult to predict accurately the duration or costs of this segment. Because of incidents of unpredicted human toxicity seen in recent years, the regulatory agencies and public demands for safety of new drug candidates have become very strict, and safety issues are dominant when identifying a clinical drug candidate