Academic Computing Newsletter: January 1991

The Academic Computing Newsletter (Volume 6, Number 2 January 1991) reviews projects from the 1990-1991 academic year and includes the text of the SUNY Presidents\u27 Task Force on Educational Technology Report.https://digitalcommons.brockport.edu/lits_news/1040/thumbnail.jp

Going beyond the individual: How state-level characteristics relate to HPV vaccine rates in the United States

Abstract Background The human papillomavirus (HPV) vaccine is an underutilized cancer control practice in the United States. Although individual contextual factors are known to impact HPV vaccine coverage rates, the impact of macro-level elements are still unclear. The aim of this analysis was to use HPV vaccination rates to explore the underuse of an evidence-based cancer control intervention and explore broader-level correlates influencing completion rates. Methods A comprehensive database was developed using individual-level date from the National Immunization Survey (NIS)-Teen (2016) and state-level data collected from publically available sources to analyze HPV vaccine completion. Multi-level logistic models were fit to identify significant correlates. Level-1 (individual) and level-2 (state) correlates were fitted to a random intercept model. Deviance and AIC assessed model fit and sampling weights were applied. Results The analysis included 20,495 adolescents from 50 U.S. states and the District of Columbia. Teen age, gender, race/ethnicity, and maternal education were significant individual predictors of HPV completion rates. Significant state-level predictors included sex education policy, religiosity, and HPV vaccine mandate. States with the lowest HPV coverage rates were found to be conservative and highly religious. Little variation in vaccine exemptions and enacted sex and abstinence education polices were observed between states with high and low HPV vaccine coverage suggesting various contextual and situational factors impact HPV vaccine completion rates. Conclusions Given that gender, religiosity, political ideology, and education policies are predictors of HPV vaccine completion, the interaction and underlying mechanism of these factors can be used to address the underutilization of the HPV vaccine

Abstract #1182615: Panhypopituitarism Induced by COVID-19 Infection

Introduction: Coronavirus disease 2019 (COVID-19) infection has led to multiple endocrinopathies. We present a case of panhypopituitarism induced by COVID -19 infection. Case Description: 76 yo male with history of type 2 diabetes, hypertension, and 1.5 cm stable, nonfunctioning, pituitary macroadenoma diagnosed in 2017 had multiple admissions for altered mental status and hyponatremia following COVID-19 infection in April 2020. Workup revealed low free T4 0.60 ng/dL (0.8-1.8), low random cortisol 1.8 mcg/dL(2.9-19.4), high prolactin 33.5 ng/mL (2-18), low total testosterone \u3c 10 ng/dl (175-781), SHBG 32.7 nmol/L (13.3-89.5), and low gonadotropins. While hospitalized, he was diagnosed with pan-hypopituitarism and started on glucocorticoids and levothyroxine. Repeat MRI pituitary done after discharge, documented stability of the macroadenoma without hemorrhage. To date, the patient remains on glucocorticoid replacement and thyroid hormone replacement in stable state. Discussion: Hypopituitarism from any etiology has an incidence of 4.2 per 100,000. Hormone replacement therapy remains the mainstay of treatment. This case represents a patient who had unexplained recurrent hyponatremia after COVID-19 infection and later diagnosed with pan-hypopituitarism. Given the continued pandemic, more endocrinopathies related to the COVID-19 infection have been reported. We have data for other viral infections, such as SARS and Dengue, documenting pituitary dysfunction. Review of literature documents SARS infection leading to post infectious hypophysitis with resulting secondary hypocortisolism and hypothyroidism. The cause was thought to be virus binding to pituitary angiotensin-converting enzyme 2 (ACE2) receptors. There is also data supporting COVID-19 infection leading to pituitary apoplexy and hypophysitis, though the number of cases reported is limited. The pathophysiology is thought to be the COVID 19 virus binding to pituitary ACE2 receptors for which it has a 10-20-fold higher affinity. Furthermore, the hypothalamus also expresses ACE2 receptors making it a target for the virus. The binding leads to cellular destruction and autoimmune collateral damage. Hypothalamic pituitary dysfunction could be due to direct effect of virus. The virus can also lead to reversible hypophysitis

Use of recombinant virus replicon particles for vaccination against Mycobacterium ulcerans disease

Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries. The majority of clinical presentations seen in patients are ulcers on limbs that can be treated by eight weeks of antibiotic therapy. Nevertheless, scarring and permanent disabilities occur frequently and Buruli ulcer still causes high morbidity. A vaccine against the disease is so far not available but would be of great benefit if used for prophylaxis as well as therapy. In the present study, vesicular stomatitis virus-based RNA replicon particles encoding the M. ulcerans proteins MUL2232 and MUL3720 were generated and the expression of the recombinant antigens characterized in vitro. Immunisation of mice with the recombinant replicon particles elicited antibodies that reacted with the endogenous antigens of M. ulcerans cells. A prime-boost immunization regimen with MUL2232-recombinant replicon particles and recombinant MUL2232 protein induced a strong immune response but only slightly reduced bacterial multiplication in a mouse model of M. ulcerans infection. We conclude that a monovalent vaccine based on the MUL2232 antigen will probably not sufficiently control M. ulcerans infection in humans

Knowledge and Attitudes Against Covid-19 Prevention Behavior of Public Health Students

This observational quantitative research uses cross-sectional approach. The sample in this study amounted to 42 respondents who were taken using accidental sampling. Data were collected in the form of primary data using mixed questionnaires. The research was conducted in May – Juni 2022 at Faletehan University. Data were analyzed through univariate and bivariate analysis. The results of the univariate analysis showed that from 42 respondents, 15 (35,7%) public health students had poor behavior, 16 (38,1%) had poor knowledge levels, and 13 (31,0%) public health students behaved unfavorably. The results of the bivariate analysis with α = 0.05 showed that one variable related to Covid-19 prevention behavior, namely attitude with (p-value = 0.0035). On the other hand, the variable which was not related to Covid-19 prevention behavior was in knowledge level with (p-value = 08875). The conclusion is that there is a relationship between the attitude of public health students of Universitas Faletehan with Covid-19 prevention behavior. The most important and most instrumental thing in preventing Covid-19 behavior is to use a mask and wash hands using soap after handling something. Keywords: attitude, Covid-19, knowledge level, prevention behavio

Identifying COVID-19 Prevention Practices among Health Students

This study aimed to discover how health students practice COVID-19 prevention methods, particularly hand washing, wearing masks and social distancing. This study was a non-experimental quantitative descriptive research. Data was collected using a COVID-19 prevention practice questionnaire distributed to students. The population in this study were regular and professional health students at the University of Muhammadiyah Malang. The sampling technique used was accidental sampling and included 208 students. 76% of students were found to have preventive practices in the low-risk category, 21% moderate risk, and 3% high risk for transmission. 98% of the practice of wearing masks answered YES. Hand washing practices are 90% in the good category, 10% moderate, and 0% low. The social distancing practice is 55% good, 37% moderate, and 8% low. Keywords: preventive practices, COVID-19, health student

Genome sequencing of a camelpox vaccine reveals close similarity to modified Vaccinia virus Ankara (MVA)

Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of morbidity and mortality, weight loss, and low milk yield. Prevention of camelpox is performed by vaccination. In this study, we investigated the composition of a CMLV-based, live-attenuated commercial vaccine using next-generation sequencing (NGS) technology. The results of this analysis revealed genomic sequences of Modified Vaccinia virus Ankara (MVA)

Fifth Freedom, 1983-01-01

National Local News: pg1 Editorial Page: pg2 Mattachine News: pg3 GLLC News: pg6 A Tribute To Patrick Cowley: pg4 The Aural Column: pg5 Out & About: pg7 Selections By Sam: pg7 Shoe Leather Express: pg8 How Does Your Garden Grow: pg10 Gay Directory: pg11 Want Ads: pg11https://digitalcommons.buffalostate.edu/fifthfreedom/1092/thumbnail.jp

Profile Vol: 42 No: 11 October 25, 1993

October 25, 1993 employee newsletter published by the Public Relations Department to educate, inform and recognize the employees of Blue Cross and Blue Shield of Florida