132 research outputs found
Model-based measurement of epileptic tissue excitability.
International audienceIn the context of pre-surgical evaluation of epileptic patients, depth-EEG signals constitute a valuable source of information to characterize the spatiotemporal organization of paroxysmal interictal and ictal activities, prior to surgery. However, interpretation of these very complex data remains a formidable task. Indeed, interpretation is currently mostly qualitative and efforts are still to be produced in order to quantitatively assess pathophysiological information conveyed by signals. The proposed EEG model-based approach is a contribution to this effort. It introduces both a physiological parameter set which represents excitation and inhibition levels in recorded neuronal tissue and a methodology to estimate this set of parameters. It includes Sequential Monte Carlo nonlinear filtering to estimate hidden state trajectory from EEG and Particle Swarm Optimization to maximize a likelihood function deduced from Monte Carlo computations. Simulation results illustrate what it can be expected from this methodology
Realistic modeling of entorhinal cortex field potentials and interpretation of epileptic activity in the guinea pig isolated brain preparation.
Mechanisms underlying epileptic activities recorded from entorhinal cortex (EC) were studied through a computational model based on review of cytoarchitectonic and neurobiological data about this structure. The purpose of this study is to describe and use this model to interpret epileptiform discharge patterns recorded in an experimental model of ictogenesis (guinea-pig isolated brain perfused with bicuculline). A macroscopic modeling approach representing synaptic interactions between cells subpopulations in the EC was chosen for its adequacy to mimic field potentials reflecting overall dynamics rising from interconnected cells populations. Therefore, intrinsic properties of neurons were not included in the modeling design. Model parameters were adjusted from an identification procedure based on quantitative comparison between real and simulated signals. For both EC deep and superficial layers, results show that the model generates very realistic signals regarding temporal dynamics, spectral features and cross-correlation values. These simulations allowed us to infer information about the evolution of synaptic transmission between principal cell and interneuronal populations and about connectivity between deep and superficial layers during the transition from background to ictal activity. In the model, this transition was obtained for increased excitation in deep versus superficial layers. Transitions between epileptiform activities (interictal spikes, fast onset activity (25Hz), ictal bursting activity) were explained by changes of parameters mainly related to GABAergic interactions. Notably, the model predicted an important role of GABA(a,fast) and GABA(b) receptor-mediated inhibition in the generation of ictal fast onset and burst activities, respectively. These findings are discussed with respect to experimental data
Biosignal Generation and Latent Variable Analysis with Recurrent Generative Adversarial Networks
The effectiveness of biosignal generation and data augmentation with
biosignal generative models based on generative adversarial networks (GANs),
which are a type of deep learning technique, was demonstrated in our previous
paper. GAN-based generative models only learn the projection between a random
distribution as input data and the distribution of training data.Therefore, the
relationship between input and generated data is unclear, and the
characteristics of the data generated from this model cannot be controlled.
This study proposes a method for generating time-series data based on GANs and
explores their ability to generate biosignals with certain classes and
characteristics. Moreover, in the proposed method, latent variables are
analyzed using canonical correlation analysis (CCA) to represent the
relationship between input and generated data as canonical loadings. Using
these loadings, we can control the characteristics of the data generated by the
proposed method. The influence of class labels on generated data is analyzed by
feeding the data interpolated between two class labels into the generator of
the proposed GANs. The CCA of the latent variables is shown to be an effective
method of controlling the generated data characteristics. We are able to model
the distribution of the time-series data without requiring domain-dependent
knowledge using the proposed method. Furthermore, it is possible to control the
characteristics of these data by analyzing the model trained using the proposed
method. To the best of our knowledge, this work is the first to generate
biosignals using GANs while controlling the characteristics of the generated
data
Metabifurcation analysis of a mean field model of the cortex
Mean field models (MFMs) of cortical tissue incorporate salient features of
neural masses to model activity at the population level. One of the common
aspects of MFM descriptions is the presence of a high dimensional parameter
space capturing neurobiological attributes relevant to brain dynamics. We study
the physiological parameter space of a MFM of electrocortical activity and
discover robust correlations between physiological attributes of the model
cortex and its dynamical features. These correlations are revealed by the study
of bifurcation plots, which show that the model responses to changes in
inhibition belong to two families. After investigating and characterizing
these, we discuss their essential differences in terms of four important
aspects: power responses with respect to the modeled action of anesthetics,
reaction to exogenous stimuli, distribution of model parameters and oscillatory
repertoires when inhibition is enhanced. Furthermore, while the complexity of
sustained periodic orbits differs significantly between families, we are able
to show how metamorphoses between the families can be brought about by
exogenous stimuli. We unveil links between measurable physiological attributes
of the brain and dynamical patterns that are not accessible by linear methods.
They emerge when the parameter space is partitioned according to bifurcation
responses. This partitioning cannot be achieved by the investigation of only a
small number of parameter sets, but is the result of an automated bifurcation
analysis of a representative sample of 73,454 physiologically admissible sets.
Our approach generalizes straightforwardly and is well suited to probing the
dynamics of other models with large and complex parameter spaces
Analysis of Jansen's model of a single cortical column
In this report we present a mathematical analysis of a simple model of a cortical column. We first recall some known biological facts about cortical columns. We then present a mathematical model of such a column, developed by a number of people including Lopes Da Silva, Jansen, Rit. Finally we analyze some aspects of its behaviour in the framework of the theory of dynamical systems using bifurcation theory and the software package XPP-Aut developed by B. Ermentrout. This mathematical approach leads us to a compact representation of the model that allows to finally discuss its adequacy with biology
Neural mass activity, bifurcations, and epilepsy.
International audienceIn this letter, we propose a general framework for studying neural mass models defined by ordinary differential equations. By studying the bifurcations of the solutions to these equations and their sensitivity to noise, we establish an important relation, similar to a dictionary, between their behaviors and normal and pathological, especially epileptic, cortical patterns of activity. We then apply this framework to the analysis of two models that feature most phenomena of interest, the Jansen and Rit model, and the slightly more complex model recently proposed by Wendling and Chauvel. This model-based approach allows us to test various neurophysiological hypotheses on the origin of pathological cortical behaviors and investigate the effect of medication. We also study the effects of the stochastic nature of the inputs, which gives us clues about the origins of such important phenomena as interictal spikes, interictal bursts, and fast onset activity that are of particular relevance in epilepsy
Mechanisms of intermittent state transitions in a coupled heterogeneous oscillator model of epilepsy
This is the final version of the article. Available from BioMed Central/SpringerOpen via the DOI in this record.We investigate the dynamic mechanisms underlying intermittent state transitions in a recently proposed neural mass model of epilepsy. A low dimensional model is constructed, which preserves two key features of the neural mass model, namely (i) coupling between oscillators and (ii) heterogeneous proximity of these oscillators to a bifurcation between distinct limit cycles. We demonstrate that state transitions due to intermittency occur in the abstract model. This suggests that there is a general bifurcation mechanism responsible for this behaviour and that this is independent of the precise form of the evolution equations. Such abstractions of neural mass models allow a deeper insight into underlying dynamic and physiological mechanisms, and also allow the more efficient exploration of large scale brain dynamics in disease.MG acknowledges funding from the EPSRC through a postdoctoral prize fellowship
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