Accurate and reliable segmentation of the optic disc in digital fundus images

We describe a complete pipeline for the detection and accurate automatic segmentation of the optic disc in digital fundus images. This procedure provides separation of vascular information and accurate inpainting of vessel-removed images, symmetry-based optic disc localization, and fitting of incrementally complex contour models at increasing resolutions using information related to inpainted images and vessel masks. Validation experiments, performed on a large dataset of images of healthy and pathological eyes, annotated by experts and partially graded with a quality label, demonstrate the good performances of the proposed approach. The method is able to detect the optic disc and trace its contours better than the other systems presented in the literature and tested on the same data. The average error in the obtained contour masks is reasonably close to the interoperator errors and suitable for practical applications. The optic disc segmentation pipeline is currently integrated in a complete software suite for the semiautomatic quantification of retinal vessel properties from fundus camera images (VAMPIRE)

Investigation of Optimal Image Inpainting Techniques for Image Reconstruction and Image Restoration Applications

People in today's society take a lot of pictures with their smartphones and also make an effort to keep their old photographs safe, but with time, those photographs deteriorate. Image inpainting is the art of reconstructing damaged or missing parts of an image. Repairing scratches in photographs or film negatives, or adding or removing elements like stamped dates or "red-eye," are all possible through inpainting. In order to restore the image many techniques have been developed, significant techniques include exemplar based inpainting, coherent based inpainting and method for correction of non-uniform illumination. The four main applications of these image inpainting techniques are scratch removal, text removal, object removal and image restoration. However, all the four image inpainting applications cannot be implemented using a single technique. According to the literature, there has been relatively less work done in the field of image inpainting applications. Investigation has been carried out to find the suitability of these three techniques for the four above mentioned image inpainting applications based on two performance metrics

Image Inpainting with Improved Storage Capability using DCT

Nowadays, tremendous amount of digital media is generating but having grazes on it. In this paper we proposed new idea to remove the graze from image, called image inpainting where in, Exemplar based image inpainting follows discrete cosine transform . The exemplar based image inpainting is based on copy-and-paste texture synthesis for reconstructing damaged parts of an image. Based on exemplar-matching techniques performance and speed of algorithm increases but size of image is also increases so, we proposed discrete cosine transform for reducing the size of image, removing noise and ultimately provides it good quality of image

Glaucoma Detection from Color Fundus Images

Glaucoma is a pathological condition, progressive neurodegeneration of the optic nerve, which causes vision loss. The damage to the optic nerve occurs due to the increase in pressure within the eye. Glaucoma is evaluated by monitoring intra ocular pressure (IOP), visual field and the optic disc appearance (cup-to-disc ratio). Cup-to disc ratio (CDR) is normally a time invariant feature. Therefore, it is one of the most accepted indicator of this disease and the disease progression. In this paper, active contour method is used to find the CDR from the color fundus images to determine pathological process of glaucoma. The method is applied on 25 nos of color fundus images obtained from optic disc organization UK having normal and pathological images. The proposed technique able to categorize all the glaucoma disease images

Fundus image analysis for automatic screening of ophthalmic pathologies

En los ultimos años el número de casos de ceguera se ha reducido significativamente. A pesar de este hecho, la Organización Mundial de la Salud estima que un 80% de los casos de pérdida de visión (285 millones en 2010) pueden ser evitados si se diagnostican en sus estadios más tempranos y son tratados de forma efectiva. Para cumplir esta propuesta se pretende que los servicios de atención primaria incluyan un seguimiento oftalmológico de sus pacientes así como fomentar campañas de cribado en centros proclives a reunir personas de alto riesgo. Sin embargo, estas soluciones exigen una alta carga de trabajo de personal experto entrenado en el análisis de los patrones anómalos propios de cada enfermedad. Por lo tanto, el desarrollo de algoritmos para la creación de sistemas de cribado automáticos juga un papel vital en este campo. La presente tesis persigue la identificacion automática del daño retiniano provocado por dos de las patologías más comunes en la sociedad actual: la retinopatía diabética (RD) y la degenaración macular asociada a la edad (DMAE). Concretamente, el objetivo final de este trabajo es el desarrollo de métodos novedosos basados en la extracción de características de la imagen de fondo de ojo y clasificación para discernir entre tejido sano y patológico. Además, en este documento se proponen algoritmos de pre-procesado con el objetivo de normalizar la alta variabilidad existente en las bases de datos publicas de imagen de fondo de ojo y eliminar la contribución de ciertas estructuras retinianas que afectan negativamente en la detección del daño retiniano. A diferencia de la mayoría de los trabajos existentes en el estado del arte sobre detección de patologías en imagen de fondo de ojo, los métodos propuestos a lo largo de este manuscrito evitan la necesidad de segmentación de las lesiones o la generación de un mapa de candidatos antes de la fase de clasificación. En este trabajo, Local binary patterns, perfiles granulométricos y la dimensión fractal se aplican de manera local para extraer información de textura, morfología y tortuosidad de la imagen de fondo de ojo. Posteriormente, esta información se combina de diversos modos formando vectores de características con los que se entrenan avanzados métodos de clasificación formulados para discriminar de manera óptima entre exudados, microaneurismas, hemorragias y tejido sano. Mediante diversos experimentos, se valida la habilidad del sistema propuesto para identificar los signos más comunes de la RD y DMAE. Para ello se emplean bases de datos públicas con un alto grado de variabilidad sin exlcuir ninguna imagen. Además, la presente tesis también cubre aspectos básicos del paradigma de deep learning. Concretamente, se presenta un novedoso método basado en redes neuronales convolucionales (CNNs). La técnica de transferencia de conocimiento se aplica mediante el fine-tuning de las arquitecturas de CNNs más importantes en el estado del arte. La detección y localización de exudados mediante redes neuronales se lleva a cabo en los dos últimos experimentos de esta tesis doctoral. Cabe destacar que los resultados obtenidos mediante la extracción de características "manual" y posterior clasificación se comparan de forma objetiva con las predicciones obtenidas por el mejor modelo basado en CNNs. Los prometedores resultados obtenidos en esta tesis y el bajo coste y portabilidad de las cámaras de adquisión de imagen de retina podrían facilitar la incorporación de los algoritmos desarrollados en este trabajo en un sistema de cribado automático que ayude a los especialistas en la detección de patrones anomálos característicos de las dos enfermedades bajo estudio: RD y DMAE.In last years, the number of blindness cases has been significantly reduced. Despite this promising news, the World Health Organisation estimates that 80% of visual impairment (285 million cases in 2010) could be avoided if diagnosed and treated early. To accomplish this purpose, eye care services need to be established in primary health and screening campaigns should be a common task in centres with people at risk. However, these solutions entail a high workload for trained experts in the analysis of the anomalous patterns of each eye disease. Therefore, the development of algorithms for automatic screening system plays a vital role in this field. This thesis focuses on the automatic identification of the retinal damage provoked by two of the most common pathologies in the current society: diabetic retinopathy (DR) and age-related macular degeneration (AMD). Specifically, the final goal of this work is to develop novel methods, based on fundus image description and classification, to characterise the healthy and abnormal tissue in the retina background. In addition, pre-processing algorithms are proposed with the aim of normalising the high variability of fundus images and removing the contribution of some retinal structures that could hinder in the retinal damage detection. In contrast to the most of the state-of-the-art works in damage detection using fundus images, the methods proposed throughout this manuscript avoid the necessity of lesion segmentation or the candidate map generation before the classification stage. Local binary patterns, granulometric profiles and fractal dimension are locally computed to extract texture, morphological and roughness information from retinal images. Different combinations of this information feed advanced classification algorithms formulated to optimally discriminate exudates, microaneurysms, haemorrhages and healthy tissues. Through several experiments, the ability of the proposed system to identify DR and AMD signs is validated using different public databases with a large degree of variability and without image exclusion. Moreover, this thesis covers the basics of the deep learning paradigm. In particular, a novel approach based on convolutional neural networks is explored. The transfer learning technique is applied to fine-tune the most important state-of-the-art CNN architectures. Exudate detection and localisation tasks using neural networks are carried out in the last two experiments of this thesis. An objective comparison between the hand-crafted feature extraction and classification process and the prediction models based on CNNs is established. The promising results of this PhD thesis and the affordable cost and portability of retinal cameras could facilitate the further incorporation of the developed algorithms in a computer-aided diagnosis (CAD) system to help specialists in the accurate detection of anomalous patterns characteristic of the two diseases under study: DR and AMD.En els últims anys el nombre de casos de ceguera s'ha reduït significativament. A pesar d'este fet, l'Organització Mundial de la Salut estima que un 80% dels casos de pèrdua de visió (285 milions en 2010) poden ser evitats si es diagnostiquen en els seus estadis més primerencs i són tractats de forma efectiva. Per a complir esta proposta es pretén que els servicis d'atenció primària incloguen un seguiment oftalmològic dels seus pacients així com fomentar campanyes de garbellament en centres regentats per persones d'alt risc. No obstant això, estes solucions exigixen una alta càrrega de treball de personal expert entrenat en l'anàlisi dels patrons anòmals propis de cada malaltia. Per tant, el desenrotllament d'algoritmes per a la creació de sistemes de garbellament automàtics juga un paper vital en este camp. La present tesi perseguix la identificació automàtica del dany retiniano provocat per dos de les patologies més comunes en la societat actual: la retinopatia diabètica (RD) i la degenaración macular associada a l'edat (DMAE) . Concretament, l'objectiu final d'este treball és el desenrotllament de mètodes novedodos basats en l'extracció de característiques de la imatge de fons d'ull i classificació per a discernir entre teixit sa i patològic. A més, en este document es proposen algoritmes de pre- processat amb l'objectiu de normalitzar l'alta variabilitat existent en les bases de dades publiques d'imatge de fons d'ull i eliminar la contribució de certes estructures retinianas que afecten negativament en la detecció del dany retiniano. A diferència de la majoria dels treballs existents en l'estat de l'art sobre detecció de patologies en imatge de fons d'ull, els mètodes proposats al llarg d'este manuscrit eviten la necessitat de segmentació de les lesions o la generació d'un mapa de candidats abans de la fase de classificació. En este treball, Local binary patterns, perfils granulometrics i la dimensió fractal s'apliquen de manera local per a extraure informació de textura, morfologia i tortuositat de la imatge de fons d'ull. Posteriorment, esta informació es combina de diversos modes formant vectors de característiques amb els que s'entrenen avançats mètodes de classificació formulats per a discriminar de manera òptima entre exsudats, microaneurismes, hemorràgies i teixit sa. Per mitjà de diversos experiments, es valida l'habilitat del sistema proposat per a identificar els signes més comuns de la RD i DMAE. Per a això s'empren bases de dades públiques amb un alt grau de variabilitat sense exlcuir cap imatge. A més, la present tesi també cobrix aspectes bàsics del paradigma de deep learning. Concretament, es presenta un nou mètode basat en xarxes neuronals convolucionales (CNNs) . La tècnica de transferencia de coneixement s'aplica per mitjà del fine-tuning de les arquitectures de CNNs més importants en l'estat de l'art. La detecció i localització d'exudats per mitjà de xarxes neuronals es du a terme en els dos últims experiments d'esta tesi doctoral. Cal destacar que els resultats obtinguts per mitjà de l'extracció de característiques "manual" i posterior classificació es comparen de forma objectiva amb les prediccions obtingudes pel millor model basat en CNNs. Els prometedors resultats obtinguts en esta tesi i el baix cost i portabilitat de les cambres d'adquisión d'imatge de retina podrien facilitar la incorporació dels algoritmes desenrotllats en este treball en un sistema de garbellament automàtic que ajude als especialistes en la detecció de patrons anomálos característics de les dos malalties baix estudi: RD i DMAE.Colomer Granero, A. (2018). Fundus image analysis for automatic screening of ophthalmic pathologies [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/99745TESI

Eye Detection and Face Recognition Across the Electromagnetic Spectrum

Biometrics, or the science of identifying individuals based on their physiological or behavioral traits, has increasingly been used to replace typical identifying markers such as passwords, PIN numbers, passports, etc. Different modalities, such as face, fingerprint, iris, gait, etc. can be used for this purpose. One of the most studied forms of biometrics is face recognition (FR). Due to a number of advantages over typical visible to visible FR, recent trends have been pushing the FR community to perform cross-spectral matching of visible images to face images from higher spectra in the electromagnetic spectrum.;In this work, the SWIR band of the EM spectrum is the primary focus. Four main contributions relating to automatic eye detection and cross-spectral FR are discussed. First, a novel eye localization algorithm for the purpose of geometrically normalizing a face across multiple SWIR bands for FR algorithms is introduced. Using a template based scheme and a novel summation range filter, an extensive experimental analysis show that this algorithm is fast, robust, and highly accurate when compared to other available eye detection methods. Also, the eye locations produced by this algorithm provides higher FR results than all other tested approaches. This algorithm is then augmented and updated to quickly and accurately detect eyes in more challenging unconstrained datasets, spanning the EM spectrum. Additionally, a novel cross-spectral matching algorithm is introduced that attempts to bridge the gap between the visible and SWIR spectra. By fusing multiple photometric normalization combinations, the proposed algorithm is not only more efficient than other visible-SWIR matching algorithms, but more accurate in multiple challenging datasets. Finally, a novel pre-processing algorithm is discussed that bridges the gap between document (passport) and live face images. It is shown that the pre-processing scheme proposed, using inpainting and denoising techniques, significantly increases the cross-document face recognition performance

Towards Better Methods of Stereoscopic 3D Media Adjustment and Stylization

Stereoscopic 3D (S3D) media is pervasive in film, photography and art. However, working with S3D media poses a number of interesting challenges arising from capture and editing. In this thesis we address several of these challenges. In particular, we address disparity adjustment and present a layer-based method that can reduce disparity without distorting the scene. Our method was successfully used to repair several images for the 2014 documentary “Soldiers’ Stories” directed by Jonathan Kitzen. We then explore consistent and comfortable methods for stylizing stereo images. Our approach uses a modified version of the layer-based technique used for disparity adjustment and can be used with a variety of stylization filters, including those in Adobe Photoshop. We also present a disparity-aware painterly rendering algorithm. A user study concluded that our layer-based stylization method produced S3D images that were more comfortable than previous methods. Finally, we address S3D line drawing from S3D photographs. Line drawing is a common art style that our layer-based method is not able to reproduce. To improve the depth perception of our line drawings we optionally add stylized shading. An expert survey concluded that our results were comfortable and reproduced a sense of depth

Automatic Detection of Optic Disc Based on PCA and Mathematical Morphology

The algorithm proposed in this paper allows to automatically segment the optic disc from a fundus image. The goal is to facilitate the early detection of certain pathologies and to fully automate the process so as to avoid specialist intervention. The method proposed for the extraction of the optic disc contour is mainly based on mathematical morphology along with principal component analysis (PCA). It makes use of different operations such as generalized distance function (GDF), a variant of the watershed transformation, the stochastic watershed, and geodesic transformations. The input of the segmentation method is obtained through PCA. The purpose of using PCA is to achieve the grey-scale image that better represents the original RGB image. The implemented algorithm has been validated on five public databases obtaining promising results. The average values obtained (a Jaccard s and Dice s coefficients of 0.8200 and 0.8932, respectively, an accuracy of 0.9947, and a true positive and false positive fractions of 0.9275 and 0.0036) demonstrate that this method is a robust tool for the automatic segmentation of the optic disc. Moreover, it is fairly reliable since it works properly on databases with a large degree of variability and improves the results of other state-of-the-art methods.This work was supported in part by the project IMIDTA/2010/47 and in part by projects Consolider-C (SEJ2006-14301/PSIC), "CIBER of Physiopathology of Obesity and Nutrition, an initiative of ISCIII" and Excellence Research Program PROMETEO (Generalitat Valenciana. Conselleria de Educacion, 2008-157).Morales Martínez, S.; Naranjo Ornedo, V.; Angulo Lopez, J.; Alcañiz Raya, ML. (2013). Automatic Detection of Optic Disc Based on PCA and Mathematical Morphology. IEEE Transactions on Medical Imaging. 32(4):786-796. https://doi.org/10.1109/TMI.2013.2238244S78679632

Automatic Detection and Correction for Glossy Reflections in Digital Photograph

[[abstract]]The popularization of digital technology has made shooting digital photos and using related applications a part of daily life. However, the use of flash, to compensate for low atmospheric lighting, often leads to overexposure or glossy reflections. This study proposes an auto-detection and inpainting technique to correct overexposed faces in digital photography. This algorithm segments the skin color in the photo as well as uses face detection and capturing to determine candidate bright spots on the face. Based on the statistical analysis of color brightness and filtering, the bright spots are identified. Finally, bright spots are corrected through inpainting technology. From the experimental results, this study demonstrates the high accuracy and efficiency of the method