11,179 research outputs found

    Genome-wide screening for DNA variants associated with reading and language traits

    Get PDF
    This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills.Publisher PDFPeer reviewe

    The association of dyslexia and developmental speech and language disorder candidate genes with reading and language abilities in adults

    Get PDF
    Reading and language abilities are critical for educational achievement and success in adulthood. Variation in these traits is highly heritable, but the underlying genetic architecture is largely undiscovered. Genetic studies of reading and language skills traditionally focus on children with developmental disorders; however, much larger unselected adult samples are available, increasing power to identify associations with specific genetic variants of small effect size. We introduce an Australian adult population cohort (41.7–73.2 years of age, N = 1505) in which we obtained data using validated measures of several aspects of reading and language abilities. We performed genetic association analysis for a reading and spelling composite score, nonword reading (assessing phonological processing: a core component in learning to read), phonetic spelling, self-reported reading impairment and nonword repetition (a marker of language ability). Given the limited power in a sample of this size (~80% power to find a minimum effect size of 0.005), we focused on analyzing candidate genes that have been associated with dyslexia and developmental speech and language disorders in prior studies. In gene-based tests, FOXP2, a gene implicated in speech/language disorders, was associated with nonword repetition (p < .001), phonetic spelling (p = .002) and the reading and spelling composite score (p < .001). Gene-set analyses of candidate dyslexia and speech/language disorder genes were not significant. These findings contribute to the assessment of genetic associations in reading and language disorders, crucial for understanding their etiology and informing intervention strategies, and validate the approach of using unselected adult samples for gene discovery in language and reading

    Development of a Family Literacy Program to Improve English Reading and Language Acquisition of Limited English Speaking Parents and Children.

    Get PDF
    A family literacy program to assist Hispanic parents and children in improving English reading and language acquisition skills was developed. Limited English speaking families in Quincy, Washington were served by a variety of lessons, developed in response to need. The results showed a desire by families to continue with the project, as well as an higher achievement in score on the reading and language sub-tests of the Metropolitan Achievement Test by students having a seventy percent program attendance rate in comparison with limited English speaking students of non-participating families. Program modifications for the following school year were discussed

    Relationships among Constructs of L2 Chinese Reading and Language Background.

    Get PDF
    Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017

    A Holistic Reading and Language Arts Approach for the Intermediate Grades

    Get PDF
    The recent push to use a whole language approach in the classroom has generally focused on the primary grade level. However, the integrated reading/language arts model described in this article was designed to meet the needs of Chapter I sixth grade students. The program provides for the integration of reading with the other language arts: speaking, writing, and listening
    • 

    corecore