Toward Adaptation of fNIRS Instrumentation to Airborne Environments

The paper reviews potential applications of functional Near-Infrared Spectroscopy (fNIRS), a well-known medical diagnostic technique, to monitoring the cognitive state of pilots with a focus on identifying ways to adopt this technique to airborne environments. We also discuss various fNIRS techniques and the direction of technology maturation of associated hardware in view of their potential for miniaturization, maximization of data collection capabilities, and user friendliness

Image informatics strategies for deciphering neuronal network connectivity

Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions. Among the neuronal structures that show morphologi- cal plasticity are neurites, synapses, dendritic spines and even nuclei. This structural remodelling is directly connected with functional changes such as intercellular com- munication and the associated calcium-bursting behaviour. In vitro cultured neu- ronal networks are valuable models for studying these morpho-functional changes. Owing to the automation and standardisation of both image acquisition and image analysis, it has become possible to extract statistically relevant readout from such networks. Here, we focus on the current state-of-the-art in image informatics that enables quantitative microscopic interrogation of neuronal networks. We describe the major correlates of neuronal connectivity and present workflows for analysing them. Finally, we provide an outlook on the challenges that remain to be addressed, and discuss how imaging algorithms can be extended beyond in vitro imaging studies

A Python-based Brain-Computer Interface Package for Neural Data Analysis

Anowar, Md Hasan, A Python-based Brain-Computer Interface Package for Neural Data Analysis. Master of Science (MS), December, 2020, 70 pp., 4 tables, 23 figures, 74 references. Although a growing amount of research has been dedicated to neural engineering, only a handful of software packages are available for brain signal processing. Popular brain-computer interface packages depend on commercial software products such as MATLAB. Moreover, almost every brain-computer interface software is designed for a specific neuro-biological signal; there is no single Python-based package that supports motor imagery, sleep, and stimulated brain signal analysis. The necessity to introduce a brain-computer interface package that can be a free alternative for commercial software has motivated me to develop a toolbox using the python platform. In this thesis, the structure of MEDUSA, a brain-computer interface toolbox, is presented. The features of the toolbox are demonstrated with publicly available data sources. The MEDUSA toolbox provides a valuable tool to biomedical engineers and computational neuroscience researchers

Motion Artifact Processing Techniques for Physiological Signals

The combination of reducing birth rate and increasing life expectancy continues to drive the demographic shift toward an ageing population and this is placing an ever-increasing burden on our healthcare systems. The urgent need to address this so called healthcare \time bomb" has led to a rapid growth in research into ubiquitous, pervasive and distributed healthcare technologies where recent advances in signal acquisition, data storage and communication are helping such systems become a reality. However, similar to recordings performed in the hospital environment, artifacts continue to be a major issue for these systems. The magnitude and frequency of artifacts can vary signicantly depending on the recording environment with one of the major contributions due to the motion of the subject or the recording transducer. As such, this thesis addresses the challenges of the removal of this motion artifact removal from various physiological signals. The preliminary investigations focus on artifact identication and the tagging of physiological signals streams with measures of signal quality. A new method for quantifying signal quality is developed based on the use of inexpensive accelerometers which facilitates the appropriate use of artifact processing methods as needed. These artifact processing methods are thoroughly examined as part of a comprehensive review of the most commonly applicable methods. This review forms the basis for the comparative studies subsequently presented. Then, a simple but novel experimental methodology for the comparison of artifact processing techniques is proposed, designed and tested for algorithm evaluation. The method is demonstrated to be highly eective for the type of artifact challenges common in a connected health setting, particularly those concerned with brain activity monitoring. This research primarily focuses on applying the techniques to functional near infrared spectroscopy (fNIRS) and electroencephalography (EEG) data due to their high susceptibility to contamination by subject motion related artifact. Using the novel experimental methodology, complemented with simulated data, a comprehensive comparison of a range of artifact processing methods is conducted, allowing the identication of the set of the best performing methods. A novel artifact removal technique is also developed, namely ensemble empirical mode decomposition with canonical correlation analysis (EEMD-CCA), which provides the best results when applied on fNIRS data under particular conditions. Four of the best performing techniques were then tested on real ambulatory EEG data contaminated with movement artifacts comparable to those observed during in-home monitoring. It was determined that when analysing EEG data, the Wiener lter is consistently the best performing artifact removal technique. However, when employing the fNIRS data, the best technique depends on a number of factors including: 1) the availability of a reference signal and 2) whether or not the form of the artifact is known. It is envisaged that the use of physiological signal monitoring for patient healthcare will grow signicantly over the next number of decades and it is hoped that this thesis will aid in the progression and development of artifact removal techniques capable of supporting this growth

Spectrum measurement, sensing, analysis and simulation in the context of cognitive radio

The radio frequency (RF) spectrum is a scarce natural resource, currently regulated locally by national agencies. Spectrum has been assigned to different services and it is very difficult for emerging wireless technologies to gain access due to rigid spectmm policy and heavy opportunity cost. Current spectrum management by licensing causes artificial spectrum scarcity. Spectrum monitoring shows that many frequencies and times are unused. Dynamic spectrum access (DSA) is a potential solution to low spectrum efficiency. In DSA, an unlicensed user opportunistically uses vacant licensed spectrum with the help of cognitive radio. Cognitive radio is a key enabling technology for DSA. In a cognitive radio system, an unlicensed Secondary User (SU) identifies vacant licensed spectrum allocated to a Primary User (PU) and uses it without harmful interference to the PU. Cognitive radio increases spectrum usage efficiency while protecting legacy-licensed systems. The purpose of this thesis is to bring together a group of CR concepts and explore how we can make the transition from conventional radio to cognitive radio. Specific goals of the thesis are firstly the measurement of the radio spectrum to understand the current spectrum usage in the Humber region, UK in the context of cognitive radio. Secondly, to characterise the performance of cyclostationary feature detectors through theoretical analysis, hardware implementation, and real-time performance measurements. Thirdly, to mitigate the effect of degradation due to multipath fading and shadowing, the use of -wideband cooperative sensing techniques using adaptive sensing technique and multi-bit soft decision is proposed, which it is believed will introduce more spectral opportunities over wider frequency ranges and achieve higher opportunistic aggregate throughput.Understanding spectrum usage is the first step toward the future deployment of cognitive radio systems. Several spectrum usage measurement campaigns have been performed, mainly in the USA and Europe. These studies show locality and time dependence. In the first part of this thesis a spectrum usage measurement campaign in the Humber region, is reported. Spectrum usage patterns are identified and noise is characterised. A significant amount of spectrum was shown to be underutilized and available for the secondary use. The second part addresses the question: how can you tell if a spectrum channel is being used? Two spectrum sensing techniques are evaluated: Energy Detection and Cyclostationary Feature Detection. The performance of these techniques is compared using the measurements performed in the second part of the thesis. Cyclostationary feature detection is shown to be more robust to noise. The final part of the thesis considers the identification of vacant channels by combining spectrum measurements from multiple locations, known as cooperative sensing. Wideband cooperative sensing is proposed using multi resolution spectrum sensing (MRSS) with a multi-bit decision technique. Next, a two-stage adaptive system with cooperative wideband sensing is proposed based on the combination of energy detection and cyclostationary feature detection. Simulations using the system above indicate that the two-stage adaptive sensing cooperative wideband outperforms single site detection in terms of detection success and mean detection time in the context of wideband cooperative sensing

CYCLOSTATIONARY FEATURES BASED LOW COMPLEXITY MUTLIRESOLUTION SPECTRUM SENSING FOR COGNITVE RADIO APPLICATIONS

The demand for variety of services using wireless communication has grown remarkably in the past few many years, consequently causing an acute problem of spectrum scarcity. Today, it is one of the most challenging problems in modern wireless communication. To overcome this, the concept of cognitive radio has been proposed and this technology is fast maturing. The first and foremost function a cognitive radio must do is to sense the spectrum as accurately as possible and do it with least complexity. Among many techniques of spectrum sensing, the Multi-resolution Spectrum Sensing (MRSS) is a popular technique in recent literature. Various multi resolution techniques are used that include wavelet based spectrum estimation and spectral hole detection, wavelet based multi-resolution in analog domain and multi-resolution multiple antenna based detection. However, the basic idea is the same - the total bandwidth is sensed using coarse resolution energy detection, then, fine sensing is applied to the portion of interest. None of these techniques, however, use multi-resolution sensing using cyclostationary features for cognitive radio applications which are more reliable but computationally expensive. In this thesis, we suggest a cyclostationary features based low complexity multi-resolution spectrum sensing for cognitive radio applications. The proposed technique discussed in this thesis is inspired by the quickness of multi-resolution and the reliability of cyclostationary feature detection. The performance of the proposed scheme is primarily evaluated by its complexity analysis and by determining the minimum signal-to-noise ratio that gives 90% probability of correct classification. Both subjective and objective evaluation show that the proposed scheme is not only superior to the commonly used energy detection method but also to various multi-resolution sensing techniques as it relies on the robustness of cyclostationary feature detection. The results found are encouraging and the proposed algorithms are proved to be not only fast but also more robust and reliable

Using the General Linear Model to Improve Performance in fNIRS Single Trial Analysis and Classification: A Perspective

Within a decade, single trial analysis of functional Near Infrared Spectroscopy (fNIRS) signals has gained significant momentum, and fNIRS joined the set of modalities frequently used for active and passive Brain Computer Interfaces (BCI). A great variety of methods for feature extraction and classification have been explored using state-of-the-art Machine Learning methods. In contrast, signal preprocessing and cleaning pipelines for fNIRS often follow simple recipes and so far rarely incorporate the available state-of-the-art in adjacent fields. In neuroscience, where fMRI and fNIRS are established neuroimaging tools, evoked hemodynamic brain activity is typically estimated across multiple trials using a General Linear Model (GLM). With the help of the GLM, subject, channel, and task specific evoked hemodynamic responses are estimated, and the evoked brain activity is more robustly separated from systemic physiological interference using independent measures of nuisance regressors, such as short-separation fNIRS measurements. When correctly applied in single trial analysis, e.g., in BCI, this approach can significantly enhance contrast to noise ratio of the brain signal, improve feature separability and ultimately lead to better classification accuracy. In this manuscript, we provide a brief introduction into the GLM and show how to incorporate it into a typical BCI preprocessing pipeline and cross-validation. Using a resting state fNIRS data set augmented with synthetic hemodynamic responses that provide ground truth brain activity, we compare the quality of commonly used fNIRS features for BCI that are extracted from (1) conventionally preprocessed signals, and (2) signals preprocessed with the GLM and physiological nuisance regressors. We show that the GLM-based approach can provide better single trial estimates of brain activity as well as a new feature type, i.e., the weight of the individual and channel-specific hemodynamic response function (HRF) regressor. The improved estimates yield features with higher separability, that significantly enhance accuracy in a binary classification task when compared to conventional preprocessing—on average +7.4% across subjects and feature types. We propose to adapt this well-established approach from neuroscience to the domain of single-trial analysis and preprocessing wherever the classification of evoked brain activity is of concern, for instance in BCI