ESTIMATION OF STRETCH REFLEX CONTRIBUTIONS OF WRIST USING SYSTEM IDENTIFICATION AND QUANTIFICATION OF TREMOR IN PARKINSON'S DISEASE PATIENTS

"The brain's motor control can be studied by characterizing the activity of spinal motor nuclei to brain control, expressed as motor unit activity recordable by surface electrodes". When a specific area is under consideration, the first step in investigation of the motor control system pertinent to it is the system identification of that specific body part or area. The aim of this research is to characterize the working of the brain's motor control system by carrying out system identification of the wrist joint area and quantifying tremor observed in Parkinson's disease patients. We employ the ARMAX system identification technique to gauge the intrinsic and reflexive components of wrist stiffness, in order to facilitate analysis of problems associated with Parkinson's disease. The intrinsic stiffness dynamics comprise majority of the total stiffness in the wrist joint and the reflexive stiffness dynamics contribute to the tremor characteristic commonly found in Parkinson's disease patients. The quantification of PD tremor entails using blind source separation of convolutive mixtures to obtain sources of tremor in patients suffering from movement disorders. The experimental data when treated with blind source separation reveals sources exhibiting the tremor frequency components of 3-8 Hz. System identification of stiffness dynamics and assessment of tremor can reveal the presence of additional abnormal neurological signs and early identification or diagnosis of these symptoms would be very advantageous for clinicians and will be instrumental to pave the way for better treatment of the disease

Time-varying Autoregressive Modeling of Nonstationary Signals

Nonstationary signal modeling is a research topic of practical interest. In this thesis, we adopt a time-varying (TV) autoregressive (AR) model using the basis function (BF) parameter estimation method for nonstationary process identification and instantaneous frequency (IF) estimation. The current TVAR model in direct form (DF) with the blockwise least-squares and recursive weighted-least-squares BF methods perform equivalently well in signal modeling, but the large estimation error may cause temporary instabilities of the estimated model. To achieve convenient model stability monitoring and pole tracking, the TVAR model in cascade form (CF) was proposed through the parameterization in terms of TV poles (represented by second order section coefficients, Cartesian coordinates, Polar coordinates), where the time variation of each pole parameter is assumed to be the linear combination of BFs. The nonlinear system equations for the TVAR model in CF are solved iteratively using the Gauss-Newton algorithm. Using the CF, the model stability is easily controlled by constraining the estimated TV poles within the unit circle. The CF model shows similar performance trends to the DF model using the recursive BF method, and the TV pole representation in Cartesian coordinates outperforms all other representations. The individual frequency variation can be finely tracked using the CF model, when several frequency components are present in the signal. Simulations were carried on synthetic sinusoidal signals with different frequency variations for IF estimation. For the TVAR model in DF (blockwise), the basis dimension (BD) is an important factor on frequency estimation accuracy. For the TVAR model in DF (recursive) and CF (Cartesian), the influences of BD are negligible. The additive white noise in the observed signal degrades the estimation performance, and the the noise effects can be reduce by using higher model order. Experiments were carried on the real electromyography (EMG) data for frequency estimation in the analysis of muscle fatigue. The TVAR modeling methods show equivalent performance to the conventional Fourier transform method

A wavelet-based correlation analysis framework to study cerebromuscular activity in essential tremor

Deep brain stimulation (DBS) provides dramatic tremor relief in patients with severe essential tremor (ET). Typically, the VIM nucleus is the most effective brain area to target for high-frequency electrical stimulation in these patients. Correlation analysis between electrical local field potential (LFP) recordings from the thalamic DBS leads and electrical muscle activity from the contralateral tremulous limb has become an attractive practical tool to interpret the LFPs and their association with the tremulous clinical manifestations. Although functional connectivity analysis between brain electrical recordings and electromyographic (EMG) signals from the tremor has been of interest to an increasing number of engineering researchers, there is no well-accepted tailored framework to consistently characterise the association between thalamic electrical recordings and the tremorogenic EMG activity. Methods. This paper proposes a novel framework to address this challenge, including an estimation of the interaction strength using wavelet cross-spectrum and phase lag index while demonstrating the statistical significance of the findings. Results. Consistent results were estimated for single and multiple trials of consecutive or partially overlapping epochs of data. The latter approach reveals a substantial increase on the range of statistically significant dynamic low-frequency interrelationships while decreasing the dynamic range of high-frequency interactions. Conclusion. Results from both simulation and real data demonstrate the feasibility and robustness of the proposed framework. Significance. This study offers the proof of principle required to implement this methodology to uncover VIM thalamic LFP-EMG interactions for (i) better understanding of the pathophysiology of tremor; (ii) objective selection of the DBS electrode contacts with the highest strength of association with the tremorogenic EMG, a particularly useful feature for the implementation of novel multicontact directional leads in clinical practice; and (iii) future research on DBS closed-loop devices

Electrohysterogram signal component cataloging with spectral and time-frequency methods

The Electrohysterogram (EHG) is a new instrument for pregnancy monitoring. It measures the uterine muscle electrical signal, which is closely related with uterine contractions. The EHG is described as a viable alternative and a more precise instrument than the currently most widely used method for the description of uterine contractions: the external tocogram. The EHG has also been indicated as a promising tool in the assessment of preterm delivery risk. This work intends to contribute towards the EHG characterization through the inventory of its components which are: • Contractions; • Labor contractions; • Alvarez waves; • Fetal movements; • Long Duration Low Frequency Waves; The instruments used for cataloging were: Spectral Analysis, parametric and non-parametric, energy estimators, time-frequency methods and the tocogram annotated by expert physicians. The EHG and respective tocograms were obtained from the Icelandic 16-electrode Electrohysterogram Database. 288 components were classified. There is not a component database of this type available for consultation. The spectral analysis module and power estimation was added to Uterine Explorer, an EHG analysis software developed in FCT-UNL. The importance of this component database is related to the need to improve the understanding of the EHG which is a relatively complex signal, as well as contributing towards the detection of preterm birth. Preterm birth accounts for 10% of all births and is one of the most relevant obstetric conditions. Despite the technological and scientific advances in perinatal medicine, in developed countries, prematurity is the major cause of neonatal death. Although various risk factors such as previous preterm births, infection, uterine malformations, multiple gestation and short uterine cervix in second trimester, have been associated with this condition, its etiology remains unknown [1][2][3]

Study of the light’s dazzling effect on the EEG signal of subjects performing tasks that require concentration

Tese de mestrado integrado, Engenharia Biomédica e Biofísica (Sinais e Imagens Médicas) Universidade de Lisboa, Faculdade de Ciências, 2019The objective of this work is to study the effect of luminous glare on the electroencephalographic (EEG) signals of subjects that perform concentration-based tasks. The increasing access to high-power and directional light sources (such as laser pointers, but also some flashlights) has led to a growing concern with the potential effects of its use. More than the direct damaging of the retina, the focus has been directed at the effects related to the change in states of concentration on individuals performing tasks whose concentration is critical (such as helicopter pilots or heavy vehicles drivers). This effect is known as ”dazzling” and is typically a temporary deleterious effect on the ability to see or concentrate. However, while damage to the retina can be quantified, glare effects, being indirect (based on the effect on the execution of a given task), are typically qualitative (or at least of more subjective quantification). In this context, the use of brain-computer interfaces capable of analyzing the brain response to external stimuli, opens a door towards the creation of a new tool to evaluate the effects of dazzle. Its potential was evaluated by defining a set of strategies involving the illumination process, EEG signal recording and analysis. A continuous performance task commonly used as an assessment in cognitive neuroscience (N-back) was used to test the attention under the effect of dazzling, in parallel with EEG signals acquisition. Statistical data analysis was performed with the R programming language. ANOVA statistical significant results (p<0.001) for answer scores and latency were obtained for differences between the levels of difficulty, both with or without dazzling. Tukey’s test further revealed that these statistical differences were on the 0-back/2-back and 1-back/2-back pairs (p<0.005). The differences in the pair 0-back/1-back were not significant. Peak band frequency statistical tests were not significant with or without dazzling. Statistical differences were found between dazzling conditions for the frequency band power. For the 0-back and 1-back levels, with the AF7-Fp1 electrode pair, T-student tests resulted in an alpha band frequency power increase (p<0.003, in both cases). The electrode pair AF8-Fp2 resulted in an alfa and beta frequency band increase for the 1-back level (p<0.014 and p<0.029, respectively). These results suggest that concentration is affected by dazzling and can be quantified by means of measuring the change in alpha and beta frequency band power. This technique holds potential and, if further researched and developed, may constitute an effective way of measuring the degree of loss of concentration under the effect of dazzling

Computational Intelligence in Electromyography Analysis

Electromyography (EMG) is a technique for evaluating and recording the electrical activity produced by skeletal muscles. EMG may be used clinically for the diagnosis of neuromuscular problems and for assessing biomechanical and motor control deficits and other functional disorders. Furthermore, it can be used as a control signal for interfacing with orthotic and/or prosthetic devices or other rehabilitation assists. This book presents an updated overview of signal processing applications and recent developments in EMG from a number of diverse aspects and various applications in clinical and experimental research. It will provide readers with a detailed introduction to EMG signal processing techniques and applications, while presenting several new results and explanation of existing algorithms. This book is organized into 18 chapters, covering the current theoretical and practical approaches of EMG research