Comparing conventional and distributed approaches to simulation in complex supply-chain health systems

Decision making in modern supply chains can be extremely daunting due to their complex nature. Discrete-event simulation is a technique that can support decision making by providing what-if analysis and evaluation of quantitative data. However, modelling supply chain systems can result in massively large and complicated models that can take a very long time to run even with today's powerful desktop computers. Distributed simulation has been suggested as a possible solution to this problem, by enabling the use of multiple computers to run models. To investigate this claim, this paper presents experiences in implementing a simulation model with a 'conventional' approach and with a distributed approach. This study takes place in a healthcare setting, the supply chain of blood from donor to recipient. The study compares conventional and distributed model execution times of a supply chain model simulated in the simulation package Simul8. The results show that the execution time of the conventional approach increases almost linearly with the size of the system and also the simulation run period. However, the distributed approach to this problem follows a more linear distribution of the execution time in terms of system size and run time and appears to offer a practical alternative. On the basis of this, the paper concludes that distributed simulation can be successfully applied in certain situations

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Distributed supply chain simulation in GRIDS

Amongst the majority of work done in supply chain simulation, papers have emerged that examine the area of model distribution. The executions of simulations on distributed hosts as a coupled model require both coordination and facilitating infrastructure. A distributed environment, the Generic Runtime Infrastructure for Distributed Simulation (GRIDS) is suggested to provide the bonding requirements for such a model. The advantages of transparently connecting the distributed components of a supply chain simulation allow the construction of a conceptual simulation while releasing the modeler from the complexities of the underlying network. The infrastructure presented demonstrates scalability without losing flexibility for future extensions based on open industry standard

A comparison of CMB- and HLA-based approaches to type I interoperability reference model problems for COTS-based distributed simulation

Commercial-off-the-shelf (COTS) simulation packages (CSPs) are software used by many simulation modellers to build and experiment with models of various systems in domains such as manufacturing, health, logistics and commerce. COTS distributed simulation deals with the interoperation of CSPs and their models. Such interoperability has been classified into six interoperability reference models. As part of an on-going standardisation effort, this paper introduces the COTS Simulation Package Emulator, a proposed benchmark that can be used to investigate Type I interoperability problems in COTS distributed simulation. To demonstrate its use, two approaches to this form of interoperability are discussed, an implementation of the CMB conservative algorithm, an example of a so-called “light” approach, and an implementation of the HLA TAR algorithm, an example of a so-called “heavy” approach. Results from experimentation over four federation topologies are presented and it is shown the HLA approach out performs the CMB approach in almost all cases. The paper concludes that the CSPE benchmark is a valid basis from which the most efficient approach to Type I interoperability problems for COTS distributed simulation can be discovered

Energy efficiency in discrete-manufacturing systems: insights, trends, and control strategies

Since the depletion of fossil energy sources, rising energy prices, and governmental regulation restrictions, the current manufacturing industry is shifting towards more efficient and sustainable systems. This transformation has promoted the identification of energy saving opportunities and the development of new technologies and strategies oriented to improve the energy efficiency of such systems. This paper outlines and discusses most of the research reported during the last decade regarding energy efficiency in manufacturing systems, the current technologies and strategies to improve that efficiency, identifying and remarking those related to the design of management/control strategies. Based on this fact, this paper aims to provide a review of strategies for reducing energy consumption and optimizing the use of resources within a plant into the context of discrete manufacturing. The review performed concerning the current context of manufacturing systems, control systems implemented, and their transformation towards Industry 4.0 might be useful in both the academic and industrial dimension to identify trends and critical points and suggest further research lines.Peer ReviewedPreprin

Global supply chains of high value low volume products

Imperial Users onl

Evaluation of Material Shortage Effect on Assembly Systems Considering Flexibility Levels

The global pandemic caused delays in global supply chains, and numerous manufacturing companies are experiencing a lack of materials and components. This material shortage affects assembly systems at various levels: process level (decreasing of the resource efficiency), system level (blocking or s tarvation of production entities), and company level (breaking the deadlines for the supplying of the products to customers or retailers). Flexible assembly systems allow dynamic reactions in such uncertain environments. However, online scheduling algorithms of current research are not considering reactions to material shortages. In the present research, we aim to evaluate the influence of material shortage on the assembly system performance. The paper presents a discrete event simulation of an assembly system. The system architecture, its behavior, the resources, their capacities, and product specific operations are included. The material shortage effect on the assembly system is compensated utilizing different system flexibility levels, characterized by operational and routing flexibility. An online control algorithm determines optimal production operation under material shortage uncertain conditions. With industrial data, different simulation scenarios evaluate the benefits of assembly systems with varying flexibility levels. Consideration of flexibility levels might facilitate exploration of the optimal flexibility level with the lowest production makespan that influence further supply chain, as makespan minimization cause reducing of delays for following supply chain entities

Supply chain management simulation: an overview

Synthesis of Vendome team research works (team belonging to GDR MACS - CNRS)Chapter 1 : Supply chain management simulation: an overvie