A novel Malonamide Periodic Mesoporous Organosilica (PMO) for controlled Ibuprofen release

Controlled drug release gained a sharply increasing interest over recent years. Multiple materials have been screened as possible drug carriers, ranging from biodegradable polymers to hydroxyapatite[1]. Periodic Mesoporous Organosilicas are valuable alternatives as they possess a high chemical and thermal stability combined with a biocompatible nature[2]. Furthermore, their large internal surface area permits a high drug loading. Careful selection of the organic ‘bridged’ functionality allows a controlled release with respect to external stimuli, such as pH or temperature, of the drugs which are adsorbed via weak and reversible interactions, e.g. H-bonding, ionic and hydrophobic-phobic interaction[3]. In this contribution a novel malonamide (MA-PMO) and a methyl-malonamide PMO (mMA-PMO) bearing a high amount of functionalities, capable of multiple intramolecular interactions, are developed and thoroughly characterized[4]. Subsequently, these hybrid materials are evaluated in the controlled drug release of Ibuprofen

Perancangan Project Management Office (PMO) Berdasarkan Fungsi PMO, Keberhasilan Proyek, dan Kinerja Organisasi (Studi Kasus PT YZ)

The PMO design in this study was carried out because the PMO need to strengthen its function so that the PMO can mobilize its full potential according to organizational goals. This study aims to determine the stages of establishing and implementing PMO Initiation, identifying PMO functions and its indicators, analyzing the importance level of results no. 2 towards improving project results & organizational performance, designing business processes & PMO Initiation SOPs. The methods used are expert judgment, AHP, descriptive statistics and BPMN. The results showed that there were 11 stages of establishing and implementing PMO Initiation, 3 PMO functions, 9 PMO function indicators, each 2 success criteria for improving project outcomes and organizational performance. This research also produces business process designs: division (1), department (5) and PMO (3). The managerial implication gives 3 draft PMO SOPs. This PMO design is based on the identification of PMO functions that affect business processes & it is the first time to be done. Modeling and documenting the business processes that occur can identify bottlenecks and improve cross-functional work alignment throughout project activities [1].Keywords: Design, PMO Functions, Project Results, Organization Performance, Business Process

A Framework to Establish a Project Management Office

This research presents a framework of the needed steps and process to establish a successful Project Management Office (PMO). This framework is driven by the different functions and roles that may be performed by a Project Management Office (PMO) as well as the type of PMO that would best serve organizations. Significant gains can be achieved by using the proposed framework. This framework is driven by the implementation of PMOs best practices that drives PMO success as well as the prevention of all pitfalls that lead to most PMOs failure. Keywords: PMO framework, PMO success, project management office, project management, PMO, establish PMO, PMO start proces

Hierarchically structured biphenylene-bridged periodic mesoporous organosilica

Novel composites of highly ordered and stable biphenyl-bridged periodic mesoporous organosilica (PMO) materials confined within the pores of anodic alumina membranes (AAM) were successfully synthesized by evaporation-induced self-assembly (EISA). 4,40-Bis(triethoxysilyl)biphenyl (BTEBP) was used as a precursor in combination with the ionic surfactant cetyltrimethylammonium bromide (CTAB) or triblock-copolymer F127 as structure-directing agents. The resulting mesophases were characterized by small angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). With ionic CTAB as a structure directing agent, samples with a mixture of the 2D-hexagonal columnar and a lamellar mesophase were obtained within the AAM channels. When using the nonionic surfactant F127, mesophases with a 2D-hexagonal circular structure were formed in the AAM channels. Additionally, a cubic Im3m phase could also be obtained with the same nonionic surfactant after the addition of lithium chloride to the precursor solution. The stability of both the circular and cubic biphenylene-bridged PMO against calcination temperatures of up to 250 °C was confirmed by NMR spectroscopy. Nitrogen sorption in the porous composite membrane shows typical type IV isotherms and narrow pore size distributions. All the biphenyl PMO/AAM composites show fluorescence due to the existence of biphenyl chromophores in the stable organosilica framework

How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse

Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of dystrophin protein. Despite this, the relationship between restoring dystrophin to established dystrophic muscle and its ability to induce clinically relevant changes in muscle function is poorly understood. In order to robustly evaluate functional improvement, we used in situ protocols in the mdx mouse to measure muscle strength and resistance to eccentric contraction-induced damage. Here, we modelled the treatment of muscle with pre-existing dystrophic pathology using antisense oligonucleotides conjugated to a cell-penetrating peptide. We reveal that 15% homogeneous dystrophin expression is sufficient to protect against eccentric contraction-induced injury. In addition, we demonstrate a >40% increase in specific isometric force following repeated administrations. Strikingly, we show that changes in muscle strength are proportional to dystrophin expression levels. These data define the dystrophin restoration levels required to slow down or prevent disease progression and improve overall muscle function once a dystrophic environment has been established in the mdx mouse model

Temperature dependent NIR emitting lanthanide-PMO/silica hybrid materials

Two materials - a mesoporous silica (MS) and a periodic mesoporous organosilica (PMO) functionalized with dipyridyl-pyridazine (dppz) units were grafted with near-infrared (NIR) emitting lanthanide (Nd3+, Er3+, Yb3+) complexes in an attempt to obtain hybrid NIR emitting materials. The parent materials: dppz-vSilica and dppz-ePMO were prepared by a hetero Diels-Alder reaction between 3,6-di(2-pyridyl)-1,2,4,5- tetrazine (dptz) and the double bonds of either ethenylene-bridged PMO (ePMO) or vinyl-silica (vSilica) and subsequent oxidation. The dppz-vSilica is reported here for the first time. The prepared lanthanide-PMO/silica hybrid materials were studied in depth for their luminescence properties at room temperature and chosen Nd3+ and Yb3+ samples also at low temperature (as low as 10 K). We show that both the dppz-vSilica and dppz-ePMO materials can be used as "platforms" for obtaining porous materials showing NIR luminescence. To obtain NIR emission these materials can be excited either in the UV or Vis region (into the pi -> pi* transitions of the ligands or directly into the f-f transitions of the Ln(3+) ions). More interestingly, when functionalized with Nd3+ or Yb3+ beta-diketonate complexes these materials showed interesting luminescence properties over a wide temperature range (10-360 K). The Yb3+ materials were investigated for their potential use as ratiometric temperature sensors

PMO within Moroccan Organizations: Towards a Synthetic Model of Implementation

The Project Management Office (PMO) is an emerging organizational structure that contributes to the improvement of both project and organizational performances, and project management maturity. Like worldwide, the PMO implementation represents a major challenge for Moroccan organizations due to several factors.. In order to explore the different aspects of PMO implementation, we adopted a qualitative approach based on conducting a set of interviews with PMO managers and experts who have implemented or have been part of a team in charge of implementing PMO. The results of the study have shown that this implementation goes through some generic steps in most cases, and the roles and functions assigned to the PMO are generally identical within the host organizations. One of the main factors influencing the PMO implementation is the top management support, seen through the organizational positioning and decision-making authority granted to the PMO. Moreover, the organizational culture and the degree of openness to innovations are determining factors too. Overall, the main challenges in PMO implementation remain change management and the maintenance of an ongoing support over time